39 research outputs found

    Primary temporal bone angiosarcoma: a case report.

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    We present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy. The patient was referred with a 2 months history of left otalgia and tinnitus with a tender swelling above the mastoid. Cranial imaging studies showed a 7 x 5 x 4 cm hypervascularized mass located in the left middle fossa with lysis of the temporal bone and extension to the subcutis. After the baby was delivered by caesarean section, the patient entered the oncology protocol. Selective embolization of the feeding vessels was followed by gross total surgical resection using a combined supra- and infra-tentorial approach. Pathological findings were those of a poorly differentiated, highly malignant sarcoma with a large epitheloid component and immunohistochemical evidence of endothelial differentiation (CD31, Factor VIII related antigen, CD34), consistent with an angiosarcoma with epitheloid features. No extra-cranial tumor was found after extensive staging. The patient received adjuvant radiotherapy followed by a course of chemotherapy consisting of 6 cycles of paclitaxel. At 15 months follow-up, she developed multiple distant metastasis to a left postauricular lymph node and to the lungs and ribs. The patient was given a second line chemotherapy using doxorubicine and ifosfamide. Despite an initial good response, she died with metastatic disease 26 months after diagnosis. We present a rare case of primary temporal bone angiosarcoma and report our experience with a multimode therapeutic approach combining surgery, radiotherapy and chemotherapy.Peer reviewe

    Congenital primary cerebral angiosarcoma

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    Marital Problems, Maternal Gatekeeping Attitudes, and Father–Child Relationships in Adolescence

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    We evaluated maternal gatekeeping attitudes as a mediator of the relation between marital problems and father-child relationships in 3 waves when children were in Grades 7-10. We assessed each parent's contribution to the marital problems experienced by the couple. Findings from mediational and cross-lagged structural equation models revealed that increased marital problem behaviors on the part of mothers at Wave 1 predicted increased maternal gatekeeping attitudes at Wave 2, which in turn predicted decreased amounts of father-adolescent interaction at Wave 3. Decreased amounts of interaction with either parent were associated within each wave with adolescents' perceptions that they mattered less to that parent. Amount of interaction with fathers at Wave 2 positively predicted changes in boys' perceptions of how much they mattered to their fathers at Wave 3, and amount of interaction with mothers at Wave 2 positively predicted changes in girls' perceptions of how much they mattered to their mothers at Wave 3. The findings did not differ for European American versus Mexican American families or for biological fathers versus step-fathers

    Effects of the interparental relationship on adolescents’ emotional security and adjustment: The important role of fathers.

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    We examined the mediational roles of multiple types of adolescents’ emotional security in relations between multiple aspects of the inter-parental relationship and adolescents’ mental health from ages 13 to 16 (N = 392). General marital quality, non-violent parent conflict, and physical intimate partner violence independently predicted mental health. Security in the father-adolescent relationship, over and above security with the mother and security in regard to parent conflict, mediated the link from general marital quality to adolescents’ mental health. With two exceptions, paths were stable for boys and girls, biological- and step-fathers, and Anglo- and Mexican-Americans. The findings reveal the need to expand the traditional foci on parent conflict and relationships with mothers to include general marital quality and relationships with fathers

    Marital problems, maternal gatekeeping attitudes, and father–child relationships in adolescence.

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    We evaluated maternal gatekeeping attitudes as a mediator of the relation between marital problems and father-child relationships in three waves when children were in 7(th) through 10(th) grade. We assessed each parent’s contribution to the marital problems experienced by the couple. Findings from mediational and cross-lagged structural equation models revealed that increased marital problem behaviors on the part of mothers at wave 1 predicted increased maternal gatekeeping attitudes at wave 2 which in turn predicted decreased amounts of father-adolescent interaction at wave 3. Decreased amounts of interaction with either parent were associated within each wave with adolescents’ perceptions that they mattered less to that parent. Amount of interaction with fathers at wave 2 positively predicted changes in boys’ perceptions of how much they mattered to their fathers at wave 3, and amount of interaction with mothers at wave 2 positively predicted changes in girls’ perceptions of how much they mattered to their mothers at wave 3. The findings did not differ for European-American versus Mexican-American families, or for biological fathers versus step-fathers
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