Junior Recital: Jarred Cook, violin

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Cook studies violin with Helen Kim.https://digitalcommons.kennesaw.edu/musicprograms/1460/thumbnail.jp

"So, Tell Me What Users Want, What They Really, Really Want!"

Equating users' true needs and desires with behavioural measures of 'engagement' is problematic. However, good metrics of 'true preferences' are difficult to define, as cognitive biases make people's preferences change with context and exhibit inconsistencies over time. Yet, HCI research often glosses over the philosophical and theoretical depth of what it means to infer what users really want. In this paper, we present an alternative yet very real discussion of this issue, via a fictive dialogue between senior executives in a tech company aimed at helping people live the life they `really' want to live. How will the designers settle on a metric for their product to optimise

Senior Recital: Katherine Johnston, clarinet

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Music Education. Ms. Johnston studies clarinet with John Warren.https://digitalcommons.kennesaw.edu/musicprograms/1295/thumbnail.jp

Senior Recital: Jarred Michael Cook, violin

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Performance. Mr. Cook studies violin with Helen Kim.https://digitalcommons.kennesaw.edu/musicprograms/1527/thumbnail.jp

Opera Theatre Gala presents Cupid: Friend or FOE

Kennesaw State University School of Music presents Opera Theater Gala, Cupid: Friend or FOE.https://digitalcommons.kennesaw.edu/musicprograms/1394/thumbnail.jp

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

The abnormal accumulation of the microtubule-binding protein tau is associated with a number of neurodegenerative conditions, and correlates with cognitive decline in Alzheimer's disease. The ubiquitin ligase carboxy terminus of Hsp70-interacting protein (CHIP) and the molecular chaperone Hsp90 are implicated in protein triage decisions involving tau, and have consequently been targeted for therapeutic approaches aimed at decreasing tau burden. Here, we present evidence that CHIP binds, ubiquitinates and regulates expression of histone deacetylase 6 (HDAC6). As the deacetylase for Hsp90, HDAC6 modulates Hsp90 function and determines the favorability of refolding versus degradation of Hsp90 client proteins. Moreover, we demonstrate that HDAC6 levels positively correlate with tau burden, while a decrease in HDAC6 activity or expression promotes tau clearance. Consistent with previous research on Hsp90 clients in cancer, we provide evidence that a loss of HDAC6 activity augments the efficacy of an Hsp90 inhibitor and drives client degradation, in this case tau. Therefore, our current findings not only identify HDAC6 as a critical factor for the regulation of tau levels, but also indicate that a multi-faceted treatment approach could more effectively arrest tau accumulation in disease

Neurocognitive Enhancement: what can we do and what should we do?

Our growing ability to alter brain function can be used to enhance the mental processes of normal individuals as well as to treat mental dysfunction in people who are ill. The prospect of neurocognitive enhancement raises many issues about what is safe, fair and otherwise morally acceptable. This article resulted from a meeting on neurocognitive enhancement that was held by the authors. Our goal is to review the state of the art in neurocognitive enhancement, its attendant social and ethical problems, and the ways in which society can address these problems