882 research outputs found
Minnesota on the Map: A Historical Atlas
Review of: "Minnesota on the Map: A Historical Atlas," by David A. Lanegran
Minnesota on the Map: A Historical Atlas
Review of: Minnesota on the Map: A Historical Atlas, by David A. Lanegran
Minnesota on the Map: A Historical Atlas
Review of: "Minnesota on the Map: A Historical Atlas," by David A. Lanegran
The Inherent Power in Mapping Ownership
A Review of The Cadastral Map in the Service of the State: A History of Property Mapping by Roger J.P. Kain and Elizabeth Baigen
Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and platelet adhesion, thereby mitigating inflammation and tissue oedema. Heparinase, a bacteria] analogue to heparanase, is known to attack the glycocalyx. However, the exact extent and specificity of degradation is unresolved. We show by electron microscopy, immunohistological staining and quantitative measurements of the constituent parts, that heparinase selectively sheds heparan sulphate from the glycocalyx, but not the synclecans
Opioid-induced constipation in intensive care patients: relief in sight?
Constipation is the most common gastrointestinal complication associated with opioid therapy in chronic pain patients, and also frequently occurs in sedated intensive care unit patients. Conventional therapy may not provide sufficient relief from constipation, which can be severe enough to limit opioid use or the dose. In a recent study on terminally ill patients suffering from laxative-resistant opioid-induced constipation, Thomas and colleagues demonstrated subcutaneous methylnaltrexone to rapidly induce defecation. This appealing result might also have favourable prospects for intensive care patients, as their outcome is often codetermined by recovery of bowel functioning
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