2,686 research outputs found

    State and Local Contracts and Subcontracts

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    The use of convergent photography in high altitude reconnaissance.

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    Thesis (M.A.)--Boston Universit

    A study of turbulent diffusion using spin echo NMR techniques

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    Cloud Computing Adoption: An SME Case Study

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    Cloud Computing is a paradigm shift in IT services delivery. This shift promises large gains in agility, efficiency and flexibility at a time when demands on data centres are growing exponentially. Despite the importance of Cloud Technology there is a dearth of research of Cloud Technology adoption in Small and Medium Enterprises. This paper seeks to address this challenge by conducting Case Study research based on Design Science and Engaged Scholarship on an SME who is in the process of developing a capability in this area. A framework called the IT-CMF was used. The framework enabled a measurement capability that will be an invaluable tool for the company as it ensures that risks are mitigated and the opportunities created by cloud computing are maximized in a planned and controlled way

    Pleiotropic and Novel Phenotypes in The \u3cem\u3eDrosophila\u3c/em\u3e Gut Caused by Mutation of \u3cem\u3eDrop-Dead\u3c/em\u3e

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    Normal gut function is vital for animal survival, and deviations from such function can contribute to malnutrition, inflammation, increased susceptibility to pathogens, diabetes, neurodegenerative diseases, and cancer. In the fruit fly Drosophila melanogaster, mutation of the gene drop-dead (drd) results in defective gut function, as measured by enlargement of the crop and reduced food movement through the gut, and drd mutation also causes the unrelated phenotypes of neurodegeneration, early adult lethality and female sterility. In the current work, adult drd mutant flies are also shown to lack the peritrophic matrix (PM), an extracellular barrier that lines the lumen of the midgut and is found in many insects including flies, mosquitos and termites. The use of a drd-gal4 construct to drive a GFP reporter in late pupae and adults revealed drd expression in the anterior cardia, which is the site of PM synthesis in Drosophila. Moreover, the ability of drd knockdown or rescue with several gal4 drivers to recapitulate or rescue the gut phenotypes (lack of a PM, reduced defecation, and reduced adult survival 10–40 days post-eclosion) was correlated to the level of expression of each driver in the anterior cardia. Surprisingly, however, knocking down drd expression only in adult flies, which has previously been shown not to affect survival, eliminated the PM without reducing defecation rate. These results demonstrate that drd mutant flies have a novel phenotype, the absence of a PM, which is functionally separable from the previously described gut dysfunction observed in these flies. As the first mutant Drosophila strain reported to lack a PM, drd mutants will be a useful tool for studying the synthesis of this structure

    Understanding Cloud Requirements - A Supply Chain Lifecycle Approach

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    Cloud Computing is offering competitive advantages to companies through flexible and, scalable access to computing resources. More and more companies are moving to cloud environments; therefore understanding the requirements for this process is both important and beneficial. The requirements for migrating from a traditional computing environment to a cloud hosting environment are discussed in this paper, considering this migration from a supply chain lifecycle perspective. The cloud supply chain is examined from a lifecycle perspective for the management of the migration project. This paper illustrates the requirements that need to be considered when adopting a cloud migration strategy and the steps to take in order to manage this process

    Give it up for climate change : a defence of the beneficiary pays principle

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    This article focuses on the normative problem of establishing how the burdens associated with implementing policies designed to prevent, or manage, climate change should be shared amongst states involved in ongoing international climate change negotiations. This problem has three key features: identifying the nature and extent of the burdens that need to be borne; identifying the type of agent that should be allocated these burdens; and distributing amongst the particular ‘tokens’ of the relevant ‘agent type’ climatic burdens according to principles that none could reasonably reject. The article defends a key role in climatic burden-sharing policy for the principle that states benefiting most from activities that cause climate change should bear the greatest burden in terms of the costs of preventing dangerous climate change. I outline two versions of this ‘beneficiary pays’ principle; examine the strengths and weakness of each version; and explore how the most plausible version (which I call the ‘unjust enrichment’ account) could be operationalized in the context of global climate governance

    The institutional care of children: a case history

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    This an attempt to indicate some of the problems connected with the administration of a Children's Home through the study of the origin, growth and contemporary problems of the Jewish Orphanage. An historical survey w1ll describe the social forces which influenced the changes in policy and affected the internal administration of the Home, the procedure in selecting children for admission, the choice of children eligible for admission and the nature of child care within the Institution. A detailed study is made of the administration of the Orphanage in the decade following the close of the last war when the children had returned to residence after evacuation. A classification is made of the reasons why children were admitted, of the ages on admission, of the period they remained in residence, and of their destination when they left. An examination is made of some of the problems which confronted the administrators both with regard to the behaviour of the children and the attitude and character of the staff. Specific reference is made to the education and religious training of the children and to the problems arising from parent-child and staff-child relationships. Although the material for this study of the institutional care of children has been gathered mainly from a Home which catered for a selective group of the population, it is believed that many of the problems discussed have implications of some significance in the general study of child care
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