Assessment of myocardial injury after reperfused infarction by T1ρ cardiovascular magnetic resonance.

BackgroundThe evolution of T1ρ and of other endogenous contrast methods (T2, T1) in the first month after reperfused myocardial infarction (MI) is uncertain. We conducted a study of reperfused MI in pigs to serially monitor T1ρ, T2 and T1 relaxation, scar size and transmurality at 1 and 4 weeks post-MI.MethodsTen Yorkshire swine underwent 90 min of occlusion of the circumflex artery and reperfusion. T1ρ, T2 and native T1 maps and late gadolinium enhanced (LGE) cardiovascular magnetic resonance (CMR) data were collected at 1 week (n = 10) and 4 weeks (n = 5). Semi-automatic FWHM (full width half maximum) thresholding was used to assess scar size and transmurality and compared to histology. Relaxation times and contrast-to-noise ratio were compared in healthy and remote myocardium at 1 and 4 weeks. Linear regression and Bland-Altman was performed to compare infarct size and transmurality.ResultsRelaxation time differences between infarcted and remote myocardial tissue were ∆T1 (infarct-remote) = 421.3 ± 108.8 (1 week) and 480.0 ± 33.2 ms (4 week), ∆T1ρ = 68.1 ± 11.6 and 74.3 ± 14.2, and ∆T2 = 51.0 ± 10.1 and 59.2 ± 11.4 ms. Contrast-to-noise ratio was CNRT1 = 7.0 ± 3.5 (1 week) and 6.9 ± 2.4 (4 week), CNRT1ρ = 12.0 ± 6.2 and 12.3 ± 3.2, and CNRT2 = 8.0 ± 3.6 and 10.3 ± 5.8. Infarct size was not significantly different for T1ρ, T1 and T2 compared to LGE (p = 0.14) and significantly decreased from 1 to 4 weeks (p < 0.01). Individual infarct size changes were ∆T1ρ = -3.8%, ∆T1 = -3.5% and ∆LGE = -2.8% from 1 - 4 weeks, but there was no observed change in infarct size for T2 or histologically.ConclusionsT1ρ was highly correlated with alterations left ventricle (LV) pathology at 1 and 4 weeks post-MI and therefore it may be a useful method endogenous contrast imaging of infarction

Erratum to: Assessment of myocardial injury after reperfused infarction by T1ρ cardiovascular magnetic resonance

BackgroundThe evolution of T1ρ and of other endogenous contrast methods (T2, T1) in the first month after reperfused myocardial infarction (MI) is uncertain. We conducted a study of reperfused MI in pigs to serially monitor T1ρ, T2 and T1 relaxation, scar size and transmurality at 1 and 4 weeks post-MI.MethodsTen Yorkshire swine underwent 90 min of occlusion of the circumflex artery and reperfusion. T1ρ, T2 and native T1 maps and late gadolinium enhanced (LGE) cardiovascular magnetic resonance (CMR) data were collected at 1 week (n = 10) and 4 weeks (n = 5). Semi-automatic FWHM (full width half maximum) thresholding was used to assess scar size and transmurality and compared to histology. Relaxation times and contrast-to-noise ratio were compared in healthy and remote myocardium at 1 and 4 weeks. Linear regression and Bland-Altman was performed to compare infarct size and transmurality.ResultsRelaxation time differences between infarcted and remote myocardial tissue were ∆T1 (infarct-remote) = 421.3 ± 108.8 (1 week) and 480.0 ± 33.2 ms (4 week), ∆T1ρ = 68.1 ± 11.6 and 74.3 ± 14.2, and ∆T2 = 51.0 ± 10.1 and 59.2 ± 11.4 ms. Contrast-to-noise ratio was CNRT1 = 7.0 ± 3.5 (1 week) and 6.9 ± 2.4 (4 week), CNRT1ρ = 12.0 ± 6.2 and 12.3 ± 3.2, and CNRT2 = 8.0 ± 3.6 and 10.3 ± 5.8. Infarct size was not significantly different for T1ρ, T1 and T2 compared to LGE (p = 0.14) and significantly decreased from 1 to 4 weeks (p < 0.01). Individual infarct size changes were ∆T1ρ = -3.8%, ∆T1 = -3.5% and ∆LGE = -2.8% from 1 - 4 weeks, but there was no observed change in infarct size for T2 or histologically.ConclusionsT1ρ was highly correlated with alterations left ventricle (LV) pathology at 1 and 4 weeks post-MI and therefore it may be a useful method endogenous contrast imaging of infarction

The impact of small motion on the visualization of coronary vessels and lesions in cardiac CT: A simulation study.

PurposeCoronary x-ray computed tomography angiography (CCTA) is used to non-invasively assess coronary artery geometry and has, combined with computational modeling, demonstrated the potential to identify physiologically significant lesions. These measurements require robust and accurate coronary imaging and delineation of vessels despite the presence of small motion. This simulation study characterizes the impact of small, uncorrected vessel drifts during data acquisition on the assessment of vessel intensity, diameter, and shape.MethodsWe developed a digital phantom and simulated projection data for a clinical scanner geometry for a range of vessel drifts that can occur during relative vessel stasis (0 to 2 mm per 360° gantry rotation) for vessels between 0.2 and 3.0 mm in diameter (covering 0% through 93% stenosis of a 3 mm vessel). In addition to the impact of vessel drift, we evaluated the performance of half-scan acquisitions (relative to full-scans) over a range of gantry positions. The performance of FDK reconstructions was compared to an iterative technique and potential improvement in sampling from focal spot deflection and quarter detector offset was compared.ResultsAt rest, vessel intensity and diameter were accurately obtained in vessels greater than 1.5 mm with all vessels appearing circular in shape (major-to-minor axis ratio ~1). Vessels between 1.5 and 0.2 mm in diameter demonstrated a rapid decrease in signal intensity with full width half maximum (FWHM) vessel diameters remaining above 0.75 mm as true vessel diameter decreased. Uncorrected vessel motion resulted in decreased vessel intensity, increased vessel diameter, and distortion of vessel shape. The extent of these changes depended on both the position of the gantry as well as the reconstruction approach (half- vs. full-scan). FDK reconstruction results depended on choice of filter with Ram-Lak results yielding comparable performance to an unconstrained iterative reconstruction. Focal spot deflection and quarter detector offset did not result in large changes in performance, likely due to the high sampling density near the isocenter.ConclusionsDespite improvement in gantry speed and acquisition of coronary images during cardiac phases that have relatively stationary vessels, small coronary drifts (0-2 mm per 360° rotation) have been reported and if uncorrected, can present challenges to visual grading and computational modeling of stenoses because vessels will appear dimmer, larger, and more ellipsoidal in shape. The impact of a particular motion depends on the gantry position, the use of half vs. full-scan acquisitions, and the reconstruction technique

Evaluation of Myocardial Perfusion and Immune Cell Response in Cardiac Allograft Dysfunction of Heart-Transplant Patients

Background We investigated the myocardial perfusion differences and changes in immune cell response in heart-transplant patients with nonspecific graft dysfunction (NGD) compared to cardiac allograft vasculopathy (CAV) patients and normal heart-transplant patients. Methods and Results We prospectively studied 17 heart-transplant patients (59.8±14.1 years, 78% male) from January to June 2016. Regadenoson stress cardiac MRI was performed in the patients and peripheral blood obtained contemporaneously to isolate peripheral blood mononuclear cells (PBMCs). Stress myocardial perfusion showed significantly decreased myocardial perfusion using maximum upslope method in NGD and CAV patients compared to normal heart-transplant patients. Myocardial scar by late gadolinium enhancement also was significantly increased in nonspecific graft dysfunction patients compared to normal. Evaluation of PBMCs by flow cytometry showed a trend towards increased activated HLA-DR + T cells in NGD patients compared to normal. Clinical outcomes for cardiac hospitalization, allograft loss/retransplant, death were assessed at 3 years. Conclusions NGD shows decreased stress myocardial perfusion by cardiac MRI and a trend towards increased activated T cells in PBMCs, suggestive of an immune-mediated cause for allograft dysfunction

Targeted Coronary Artery Calcium Screening in High-Risk Younger Individuals Using Consumer Genetic Screening Results

ObjectivesThe goal of this study was to assess the utility of a genetic risk score (GRS) in targeted coronary artery calcium (CAC) screening among young individuals.BackgroundEarly CAC screening and preventive therapy may reduce long-term risk of a coronary heart disease (CHD) event. However, identifying younger individuals at increased risk remains a challenge. GRS for CHD are age independent and can stratify individuals on various risk trajectories.MethodsUsing 142 variants associated with CHD events, we calculated a GRS in 1,927 individuals in the CARDIA (Coronary Artery Risk Development in Young Adults) cohort (aged 32 to 47 years) and 6,600 individuals in the MESA (Multi-Ethnic Study of Atherosclerosis) cohort (aged 44 to 87 years). We assessed GRS utility to predict CAC presence in the CARDIA cohort and stratify individuals of varying risk for CAC presence over the lifetime in both cohorts.ResultsThe GRS predicted CAC presence in CARDIA males. It was not predictive in CARDIA females, which had a CAC prevalence of 6.4%. In combined analysis of the CARDIA and MESA cohorts, the GRS was predictive of CAC in both males and females and was used to derive an equation for the age at which CAC probability crossed a predetermined threshold. When assessed in combination with traditional risk factors, the GRS further stratified individuals. For individuals with an equal number of traditional risk factors, probability of CAC reached 25% approximately 10 years earlier for those in the highest GRS quintile compared to the lowest.ConclusionsThe GRS may be used to target high-risk younger individuals for early CAC screening

4D Flow Vorticity Visualization Predicts Regions of Quantitative Flow Inconsistency for Optimal Blood Flow Measurement.

PurposeTo evaluate whether automated vorticity mapping four-dimensional (4D) flow MRI can identify regions of quantitative flow inconsistency.Materials and methodsIn this retrospective study, 35 consecutive patients who underwent MR angiography with 4D flow MRI at 3.0 T from December 2017 to October 2018 were analyzed using a λ 2-based technique for vorticity visualization and quantification. The patients were aged 58.6 years ± 14.4 (standard deviation), 12 were women, 18 had ascending aortic aneurysms (maximal diameter > 4.0 cm), and 10 had bicuspid aortic valves. Flow measurements were made in the ascending aorta (aAo), mid-descending aorta, main pulmonary artery, and superior vena cava. Statistical tests included t tests and F tests with a type I error threshold (α) of .05.ResultsThe 35 patients were visually classified as having no (n = 9), mild (n = 8), moderate (n = 11), or severe vorticity (n = 7). Across all patients, standard deviation of cardiac output in the aAo (0.58 L/min ± 0.45) was significantly (P < .001) higher than in the pulmonary arteries (0.15 L/min ± 0.10) and descending aorta and superior vena cava (0.14 L/min ± 0.12). The standard deviation of cardiac output observed in the aAo was significantly greater (P < .01) in patients with moderate or severe vorticity (0.73 L/min ± 0.55) than in those with none or mild vorticity (0.44 L/min ± 0.26).ConclusionCardiac output and blood flow are essential MRI measurements in the evaluation of structural heart disease. Vorticity visualization may be used to help guide optimal location for flow quantification.© RSNA, 2020See also the commentary by Markl in this issue

A novel method for evaluating regional RV function in the adult congenital heart with low-dose CT and SQUEEZ processing.

BackgroundMeasuring local RV function in adult congenital heart disease (ACHD) with echocardiography or MRI is challenging because of the complex geometry and existing pacing devices. Visual assessment of ventricular function via low-dose cardiac CT has been recently performed. This pilot study assessed whether low-dose 4D cine CT combined with automatic measurement of regional shortening could quantify right-ventricular function in ACHD patients.MethodsSeven patients with Tetralogy of Fallot either contraindicated for MRI or assessed for coronary artery disease and seven non-congenital patients were imaged with ECG-gated cardiac CT utilizing a 320-detector row scanner. Right ventricular global function and regional shortening were quantified.ResultsNon-congenital patients were imaged with 2.9±2.1mSv and 395±359 HU blood-myocardium contrast. The ACHD patients were imaged with 2.1±1.3mSv and 726±296 HU contrast. Right ventricles of the ACHD patients had higher end-diastolic volume (297±107mL vs 123±34mL, p=0.001), lower ejection fraction (32.0±4.9% vs 45.0±6.0%, p=0.001), and higher dyskinetic fraction (10.9±3.7% vs 2.6±2.8%, p<0.001) relative to the non-congenital controls.ConclusionsIn this initial pilot study, right ventricular global and regional systolic function were measured using low-dose cine CT with SQUEEZ quantification in non-congenital patients as well as ACHD patients with Tetralogy of Fallot. Unique regional features of RV dyskinesia were identified in the ACHD patients which could yield a more precise quantification of RV function