BTG interacts with retinoblastoma to control cell fate in Dictyostelium.

In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation. Though conceptually distinct, they are often causally related and functional interactions between the cell cycle machinery and cell fate control networks are fundamental to coordinate growth and differentiation. A switch from proliferation to differentiation may also be important in the life cycle of single-celled organisms, and genes which arose as regulators of microbial differentiation may be conserved in higher organisms. Studies in microorganisms may thus contribute to understanding the molecular links between cell cycle machinery and the determination of cell fate choice networks. Here we show that in the amoebozoan D. discoideum, an ortholog of the metazoan antiproliferative gene btg controls cell fate, and that this function is dependent on the presence of a second tumor suppressor ortholog, the retinoblastoma-like gene product. Specifically, we find that btg-overexpressing cells preferentially adopt a stalk cell (and, more particularly, an Anterior-Like Cell) fate. No btg-dependent preference for ALC fate is observed in cells in which the retinoblastoma-like gene has been genetically inactivated. Dictyostelium btg is the only example of non-metazoan member of the BTG family characterized so far, suggesting that a genetic interaction between btg and Rb predated the divergence between dictyostelids and metazoa. While the requirement for retinoblastoma function for BTG antiproliferative activity in metazoans is known, an interaction of these genes in the control of cell fate has not been previously documented. Involvement of a single pathway in the control of mutually exclusive processes may have relevant implication in the evolution of multicellularity

Emotional Regulation and Interpersonal Effectiveness as Mechanisms of Change for Treatment Outcomes Within a DBT Program for Adolescents

Predictive modeling was used to identify the degree that hypothesized moderators of dialectical behavioral therapy for adolescents (DBT-A) treatment outcomes predicted anxiety and depression symptoms over time. Participants were 66 adolescents (41 girls; 25 boys) with a mean age of 15.38 years (SD = 1.51) who completed a 7-week DBT-A intervention. Analyses revealed convergent models, wherein emotion regulation and interpersonal effectiveness were substantial predictors of change in the symptoms of anxiety, F(4, 65) = 23.21, p \u3c .01, R2 = .60, and depression, F(4, 65) = 29.76, p \u3c .01, R2 = .66

Meromorphic traveling wave solutions of the complex cubic-quintic Ginzburg-Landau equation

We look for singlevalued solutions of the squared modulus M of the traveling wave reduction of the complex cubic-quintic Ginzburg-Landau equation. Using Clunie's lemma, we first prove that any meromorphic solution M is necessarily elliptic or degenerate elliptic. We then give the two canonical decompositions of the new elliptic solution recently obtained by the subequation method.Comment: 14 pages, no figure, to appear, Acta Applicandae Mathematica

Multivortex Solutions of the Weierstrass Representation

The connection between the complex Sine and Sinh-Gordon equations on the complex plane associated with a Weierstrass type system and the possibility of construction of several classes of multivortex solutions is discussed in detail. We perform the Painlev\'e test and analyse the possibility of deriving the B\"acklund transformation from the singularity analysis of the complex Sine-Gordon equation. We make use of the analysis using the known relations for the Painlev\'{e} equations to construct explicit formulae in terms of the Umemura polynomials which are $\tau$-functions for rational solutions of the third Painlev\'{e} equation. New classes of multivortex solutions of a Weierstrass system are obtained through the use of this proposed procedure. Some physical applications are mentioned in the area of the vortex Higgs model when the complex Sine-Gordon equation is reduced to coupled Riccati equations.Comment: 27 pages LaTeX2e, 1 encapsulated Postscript figur

Could health information systems enhance the quality of Aboriginal health promotion? A retrospective audit of Aboriginal health programs in the Northern Territory of Australia.

BACKGROUND:In Australia, health services are seeking innovative ways to utilize data stored in health information systems to report on, and improve, health care quality and health system performance for Aboriginal Australians. However, there is little research about the use of health information systems in the context of Aboriginal health promotion. In 2008, the Northern Territory's publicly funded healthcare system introduced the quality improvement program planning system (QIPPS) as the centralized online system for recording information about health promotion programs. The purpose of this study was to explore the potential for utilizing data stored in QIPPS to report on quality of Aboriginal health promotion, using chronic disease prevention programs as exemplars. We identify the potential benefits and limitations of health information systems for enhancing Aboriginal health promotion. METHODS:A retrospective audit was undertaken on a sample of health promotion projects delivered between 2013 and 2016. A validated, paper-based audit tool was used to extract information stored in the QIPPS online system and report on Aboriginal health promotion quality. Simple frequency counts were calculated for dichotomous and categorical items. Text was extracted and thematically analyzed to describe community participation processes and strategies used in Aboriginal health promotion. RESULTS:39 Aboriginal health promotion projects were included in the analysis. 34/39 projects recorded information pertaining to the health promotion planning phases, such as statements of project goals, 'needs assessment' findings, and processes for consulting Aboriginal people in the community. Evaluation findings were reported in approximately one third of projects and mostly limited to a recording of numbers of participants. For almost half of the projects analyzed, community participation strategies were not recorded. CONCLUSION:This is the first Australian study to shed light on the feasibility of utilizing data stored in a purposefully designed health promotion information system. Data availability and quality were limiting factors for reporting on Aboriginal health promotion quality. Based on our learnings of QIPPS, strategies to improve the quality and accuracy of data entry together with the use of quality improvement approaches are needed to reap the potential benefits of future health promotion information systems

A consideration of the effects of the slip displacement on fretting fatigue behaviour

Published versio

Improvement of Surface Accuracy and Shop Floor Feed Rate Smoothing Through Open CNC Monitoring System and Cutting Simulation

AbstractIn the milling process of complex workpiece shapes the feed rate normally becomes instable due to the high degree of surface curvature that requires high acceleration and deceleration of the interpolated axes. This condition impacts on process time and on the surface accuracy regarding the manufactured part form and texture. The challenge to simulate the real machine and control behavior requires accurate models with a set of experiments to tune and dimension the model to the respective machine tool. The aim is to improve the HSC milling process of complex surfaces before removing any material. In this paper experiments show that the surface form accuracy and texture can be optimized through an automatic feed rate smoothing of the finishing operation directly on the machine tool. The axis positions and spindle speeds monitored through the open CNC are used as input for a geometric cutting simulation, thus enabling to predict and optimize the surface quality

Solitary waves of nonlinear nonintegrable equations

Our goal is to find closed form analytic expressions for the solitary waves of nonlinear nonintegrable partial differential equations. The suitable methods, which can only be nonperturbative, are classified in two classes. In the first class, which includes the well known so-called truncation methods, one \textit{a priori} assumes a given class of expressions (polynomials, etc) for the unknown solution; the involved work can easily be done by hand but all solutions outside the given class are surely missed. In the second class, instead of searching an expression for the solution, one builds an intermediate, equivalent information, namely the \textit{first order} autonomous ODE satisfied by the solitary wave; in principle, no solution can be missed, but the involved work requires computer algebra. We present the application to the cubic and quintic complex one-dimensional Ginzburg-Landau equations, and to the Kuramoto-Sivashinsky equation.Comment: 28 pages, chapter in book "Dissipative solitons", ed. Akhmediev, to appea

A q-analogue of gl_3 hierarchy and q-Painleve VI

A q-analogue of the gl_3 Drinfel'd-Sokolov hierarchy is proposed as a reduction of the q-KP hierarchy. Applying a similarity reduction and a q-Laplace transformation to the hierarchy, one can obtain the q-Painleve VI equation proposed by Jimbo and Sakai.Comment: 14 pages, IOP style, to appear in J. Phys. A Special issue "One hundred years of Painleve VI

Upper ocean mixing controls the seasonality of planktonic foraminifer fluxes and associated strength of the carbonate pump in the oligotrophic North Atlantic

Oligotrophic regions represent up to 75% of Earth's open-ocean environments. They are thus areas of major importance in understanding the plankton community dynamics and biogeochemical fluxes. Here we present fluxes of total planktonic foraminifera and 11 planktonic foraminifer species measured at the Oceanic Flux Program (OFP) time series site in the oligotrophic Sargasso Sea, subtropical western North Atlantic Ocean. Foraminifera flux was measured at 1500 m water depth, over two ~ 2.5-year intervals: 1998–2000 and 2007–2010. We find that foraminifera flux was closely correlated with total mass flux, carbonate and organic carbon fluxes. We show that the planktonic foraminifera flux increases approximately 5-fold during the winter–spring, contributing up to ~ 40% of the total carbonate flux. This was primarily driven by increased fluxes of deeper-dwelling globorotaliid species, which contributed up to 90% of the foraminiferal-derived carbonate during late winter–early spring. Interannual variability in total foraminifera flux, and in particular fluxes of the deep-dwelling species (Globorotalia truncatulinoides, Globorotalia hirsuta and Globorotalia inflata), was related to differences in seasonal mixed layer dynamics affecting the strength of the spring phytoplankton bloom and export flux, and by the passage of mesoscale eddies. As these heavily calcified, dense carbonate tests of deeper-dwelling species (3 times denser than surface dwellers) have greater sinking rates, this implies a high seasonality of the biological carbonate pump in oligotrophic oceanic regions. Our data suggest that climate cycles, such as the North Atlantic Oscillation, which modulates nutrient supply into the euphotic zone and the strength of the spring bloom, may also in turn modulate the production and flux of these heavily calcified deep-dwelling foraminifera by increasing their food supply, thereby intensifying the biological carbonate pump