Cadomian and post-cadomian tectonics west of the Rhodope Massif – The Frolosh greenstone belt and the Ograzhdenian metamorphic supercomplex

The Frolosh Greenstone Belt (FGB) is traced at a distance of more than 200 km in the territories of Bulgaria, Macedonia and Serbia. It consists of various greenschist-facies rocks (actinolite schists, phyllites, calcareous schists, impure marbles, metasandstones, metadiabases, massive green rocks, etc.) of the Frolosh metamorphic complex with bodies of metabasites (including lherzolites), and inliers (retrogressed mica gneisses and migmatites) from the Ograzhdenian supercomplex. The complex is in­truded by bodies of gabbro (occasionally with ultramafic cumulates), diorites to granites (Struma diorite formation). U-Pb studies on zircons yielded Cadomian ages within the time span between c. 574 and 517 Ma. The Frolosh complex covers the ultrametamorphic (migmatized gneisses and amphibolites; tourma­line-biotite schists; quartzo-feldspathic gneisses; lensoid bodies of metaperidotites to norites) of the Ograzhdenian supercomplex. The Ograzhdenian rocks are intersected by diatectic metagranites over­printed by amphibolite-facies metamorphism. Dominant U-Pb ages vary between 470 and 430 Ma. The contact between the Frolosh complex and the Ograzhdenian supercomplex has been subject of long dis­cussion and controversial interpretations. Now we emphasize on the multistage developments of both complexes as demonstrated both by field evidence and isotopic dating. The Ograzhdenian supercomplex has been subject of Precambrian tectonometamorphism witnessed by Rb-Sr whole-rock isochron data and relict U-Pb zircon data. Ordovician to Silurian anatectites (metatectic migmatization, diatexis) are in­truded by Permo-Triassic granites. The contact between the Ograzhdenian supercomplex and the covering Frolosh complex is regarded as a thick complex zone of multistage tectonometamorphic development rather than a “razor-blade” surface of one-stage origin. As a boundary between suprastructure and infra­structure, it played an important role throughout the Phanerozoic, and acted as a screen with a steep ther­mal gradient during the Ordovician-Silurian anatexis and metamorphism in the Ograzhdenian supercom­plex. For to verify this hypothesis, new detailed structural and isotopic studies are needed

Subglottotracheal Adenoid Cystic Carcinoma in a 16-Year-Old Female—A Case Report

Cystic adenoid carcinoma (ACC) is a rare malignant epithelial tumor arising from exocrine glands and accounts for only 1% of head and neck cancers. ACCs are common in the fifth and sixth decades of life, predominantly in women, and characterized by slow progression, local aggression, recurrence, and high metastasis. Subglottotracheal ACC is a rare tumor in the pediatric population, with only a few cases reported in the literature. We present a case of a 16-year-old female who was diagnosed with ACC in the subglottic and tracheal region. The patient presented with respiratory failure but without a history of dysphonia, dyspnea, stridor, or dysphagia. The diagnosis was confirmed by a biopsy, and subsequent imaging studies showed a large tumor involving the subglottic and tracheal region. The therapeutic management of this patient has been challenging due to the rarity of this tumor in the pediatric population and the potential long-term complications associated with tumor recurrence and psychological impact. This case highlights the diagnostic and therapeutic challenges in the management of subglottotracheal ACC in children and the importance of a multidisciplinary approach to optimize patient outcomes

About a peri-Gondwanan-North African enlarged acceptance of the Caledonian Orogeny

The notion of “Caledonian Orogeny” is restricted by most authors to the Ordovician-Devonian thermotectonic events associated with the Laurentia-Baltica- Avalonia suturing. However, some views consider an orogeny as the sum of tectonic, metamorphic and magmatic events accompanying an entire supercontinent assembly or Wilson cycle. Following this line of thinking, the Caledonian and Variscan orogenies successively assembled Pangea. During the Ordovician Period, rifting, collision, deformation, metamorphism and magmatism took place within the Gondwana margin. All these events are known today in the basement of the Cadomian terranes from Iberia through the Alps up to the Romanian Carpathians and Balkans. We plead here for an enlargement of the “Caledonian Orogeny” terminology to these events and places, under the name of the “Caledonian North African orogenic event or Caledonian North African orogen

New U/Pb and Pb/Pb zircon ages from the Biharia terrane rocks, Apuseni Mountains, Romania

The Biharia sequence from the Apuseni Mountains is a component of the Biharia Paleozoic terrane. The Biharia terrane probably evolved as an island arc between the Cadomian Someş and Baia de Arieş terranes. A gneissic metagranodiorite associated with metabasites from the Valea Ierţii creek, was sampled for U/Pb and Pb/Pb zircon age determination. The zircons extracted out of the sampled rock were subjected both to dilution and evaporation methods. Dilution method offered Concordia intercepts at 227±23 Ma, 312±13 Ma, 465.7+8.4/-8.0 Ma, 703±21 Ma and 1604±45 Ma. Evaporated zircon grains gave 450±20 Ma and 543±17 Ma. The 227±23 Ma age and 312±13 Ma age have been interpreted as Pb loss due to the final effect of the Permian widespread magmatism and late Variscan anatexis respectively. The 465.7+8.4/-8.0 Ma and 450±50 Ma ages probably represent the protolith generation time. The 543±17 Ma is viewed as an inherited Cadomian age and the 703±21 and 1604±45 Ma might represent Cadomian and Saharan detrital zircon ages

Granulomatosis with Polyangiitis (GPA)—A Multidisciplinary Approach of a Case Report

Granulomatosis with polyangiitis is an atypical, multisystem disease with unknown etiology that generally affects both genders equally, with a predominance in the Caucasian racial group for individuals in their fourth decade. The disease affects the small vessels of the respiratory system, lungs, and kidneys. ENT manifestations are common, but ocular involvement is also frequent and can occur as an initial harbinger of the disease. The signs and symptoms of the disease are non-pathognomonic and sometimes localized, but it carries a poor prognosis if left untreated. Early diagnosis of granulomatosis with polyangiitis can be difficult and is established by a clinical examination along with laboratory tests for anti-neutrophil cytoplasmic antibodies (ANCA) and anatomopathological exam results that showcase necrosis, granulomatous inflammation, and vasculitis. Although the ocular involvement is not life threatening, it can cause blindness and may also be a sign of the active form of this systemic fatal disease. Treatment strategies involving immunosuppression and adjuvant therapies improve the prognosis. In this article we present a rare case of a patient diagnosed with granulomatosis with polyangiitis in our ENT department in 2003, with a follow-up for19 years in our clinic

Development and Preliminary Characterization of Polyester-Urethane Microparticles Used in Curcumin Drug Delivery System for Oropharyngeal Cancer

Background and Objectives: Curcumin (Cc) as an active substance is known for its anti-inflammatory, anticoagulant, antioxidant, and anti-carcinogenic effects, together with its role in cholesterol regulation, and its use in different gastrointestinal derangements. On the other hand, curcumin can be used for its properties as an inactive substance, with Cc particles being more often tested in pharmaceutical formulations for drug delivery, with promising safety records and kinetics. The aim of this research was to obtain and characterize polyurethane microparticles that can be used as a carrier with a controlled Cc release. Materials and Methods: The in vitro samples were characterized by the Zetasizer procedure, and UV–Vis spectroscopy, while the in-vivo measurements on human subjects were performed by non-invasive skin assays (trans-epidermal water loss, erythema, and skin hydration). A total of 16 patients with oropharyngeal cancer stages II and III in equal proportions were recruited for participation. Results: The experimental values of sample characteristics using the Zetasizer identified a mean structural size of 215 nm in the polyester-urethane preparate (PU), compared to 271 nm in the curcumin-based PU. Although the size was statistically significantly different, the IPDI and Zeta potential did not differ significantly (22.91 mV vs. 23.74 mV). The average age during the study period was 57.6 years for patients in the PU group, respectively, and 55.1 years in those who received the curcumin preparations. The majority of oropharyngeal cancers were of HPV-related etiology. There were no significant side effects; 75.0% of patients in the PU group reporting no side effects, compared to 87.5% in the Cc group. The 48 h TEWL measurement at the end of the experiment found a statistically significant difference between the PU and the Cc group (2.2 g/h/m2 vs. 2.6 g/h/m2). The erythema assessment showed a starting measurement point for both research groups with a 5.1-unit difference. After 48 h, the difference between PU and PU_Cc was just 1.7 units (p-value = 0.576). The overall difference compared to the reference group with sodium lauryl sulfate (SLS) was statistically significant at a 95% significance level. Conclusions: Our findings indicate the obtaining of almost homogeneous particles with a medium tendency to form agglomerations, with a good capacity of encapsulation (around 60%), a medium release rate, and a non-irritative potential. Therefore, this polyester-urethane with Cc microparticles can be tested in other clinical evaluations