15 research outputs found
Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study
Background:
People with Huntington’s disease (HD) have been observed to have lower rates of cancers.
Objective:
To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis.
Methods:
Data were obtained from the European Huntington’s disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects.
Results:
173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22–0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001).
Conclusions:
Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis
Le devoir d’aimer
Constant Léonard. Le devoir d’aimer. In: La revue pédagogique, tome 61, Juillet-Décembre 1912. pp. 348-350
Le devoir d’aimer
Constant Léonard. Le devoir d’aimer. In: La revue pédagogique, tome 61, Juillet-Décembre 1912. pp. 348-350
L'histoire Romaine sommairement comprise en quatre livres par L. Julius Florus, depuis la fondation de Rome jusques à l'Empereur Auguste : Et en dix livrets par Eutropius jusques au temps de l'Empereur Valens. Le tout tradUIT de latin en françois par L. Constant.
GLN-2800CDM, p. 98Malicki, BJ 16, n° F-37
Remontrance chrestienne et salutaire aux François qui se sont desvoyez de la vraye religion et polluez ès superstitions et idolatries de la papauté. En laquelle sont ldescouvertes les horribles impietez et abominations contenues en ceste tyrannique abjuration publiée par les supposts de l'antechrist, en ceste derniere persecution. par L.C.L.
GLN-3169CDM, p. 116Dubois, Stoer, n° 1586/
Reduced cancer Incidence in Huntington's disease. analysis in the registry study
People with Huntington's disease (HD) have been observed to have lower rates of cancers