7 research outputs found
STIFFNESS AND STRENTH ANALYSIS OF A LUG JOINT STRUCTURE
Lug joint is a kind of structure widely used in missile empennages connection. Aiming at the problem of the lug joints in a static experiment,we built the equal simplified FEA model,and systematically analyzed the influence of bolts distribution,stiffness matching of connected parts,bolt fit clearance and bolt preload on stiffness and strength of the joints.Finally,based on the analysis and manufacturability,the original structure got improved and validated by FEA simulation
HighlyQ1: Please confirm the edits made to the article title are correct. Potent and Selective NAryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B
Tumorâassociated macrophagesâeducated reparative macrophages promote diabetic wound healing
Abstract Nonhealing diabetic wounds, with persistent inflammation and damaged vasculature, have failed conventional treatments and require comprehensive interference. Here, inspired by tumorâassociated macrophages (TAMs) that produce abundant immunosuppressive and proliferative factors in tumor development, we generate macrophages to recapitulate TAMs' reparative functions, by culturing normal macrophages with TAMs' conditional medium (TAMsâCM). These TAMsâeducated macrophages (TAMEMs) outperform major macrophage phenotypes (M0, M1, or M2) in suppressing inflammation, stimulating angiogenesis, and activating fibroblasts in vitro. When delivered to skin wounds in diabetic mice, TAMEMs efficiently promote healing. Based on TAMsâCM's composition, we further reconstitute a nineâfactor cocktail to train human primary monocytes into TAMEMsCâh, which fully resemble TAMEMs' functions without using tumor components, thereby having increased safety and enabling the preparation of autologous cells. Our study demonstrates that recapitulating TAMs' unique reparative activities in nontumor cells can lead to an effective cell therapeutic approach with high translational potential for regenerative medicine
Synthesis and Biological Evaluations of a Series of Thaxtomin Analogues
Thaxtomins
are a unique family of phytotoxins with unique 4-nitroindole and diketopiperazine
fragments possessing potential herbicidal activities. This work presents
the total synthesis of natural product thaxtomin C and its analogues.
The extensive structureâactivity relationship study screens
four effective compounds, including thaxtomin A and thaxtomin C. It
is indicated that 4-nitro indole fragment is essential for phytotoxicity,
while benzyl and <i>m</i>-hydroxybenzyl substituents on
the diketopiperazine ring are favorable for the efficacy. The N-methylations
on indole and diketopiperazine show weak influence on the herbicidal
activities. The four selected compounds show effective herbicidal
activities against Brassica campestris, Amaranthus retroflexus, and Abutilon theophrasti, which are comparable or better
than dichlobenil, even at a dosage of 187.5 g ha<sup>â1</sup>. Moreover, these four compounds show good crop-selective properties
to different crops and exhibit moderate protoporphyrinogen oxidase
(PPO) enzyme inhibition. The antifungal results indicate that thaxtomin
C displays inhibition to a wide range of fungi