Development of an unbiased statistical method for the analysis of unigenic evolution-0

<p><b>Copyright information:</b></p><p>Taken from "Development of an unbiased statistical method for the analysis of unigenic evolution"</p><p>BMC Bioinformatics 2006;7():150-150.</p><p>Published online 17 Mar 2006</p><p>PMCID:PMC1434776.</p><p>Copyright © 2006 Behrsin et al; licensee BioMed Central Ltd.</p> of individual residues was averaged over a window of 1, 5, 11 or 25 codons. The hypo- or hypermutability was then plotted as a bar in the center of the specified window and the window was shifted downstream one codon at a time. Individual hypomutable regions, designated A, B, C, and D are indicated on the plot for the 11 codon window. For comparison, the difference between mutability calculated by previous methods (5) and mutability as described in this manuscript is also shown (circles)

Development of an unbiased statistical method for the analysis of unigenic evolution-1

<p><b>Copyright information:</b></p><p>Taken from "Development of an unbiased statistical method for the analysis of unigenic evolution"</p><p>BMC Bioinformatics 2006;7():150-150.</p><p>Published online 17 Mar 2006</p><p>PMCID:PMC1434776.</p><p>Copyright © 2006 Behrsin et al; licensee BioMed Central Ltd.</p>d against region length and amino acid residue number. Calculations were performed as described in the text. Only regions that are significant at the 0.005 level are plotted; the whole window is plotted whenever this significance level is achieved. If a residue is involved in more than one significant region of the same length, the region with the highest χvalue is plotted. Colours indicate χof the region and range from deep red (χ> 15, corresponding to α < 0.0001) to pale green (χ> 8, α < 0.005). Four hypomutable regions approximating regions A-D (Figure 1) are evident