The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution

On the backdrop of all acute inflammatory processes lies the activation of the resolution response. Recent years have witnessed an emerging interest in defining molecular factors that influence the resolution of inflammation. A keystone feature of the mucosal inflammatory microenvironment is hypoxia. The gastrointestinal tract, particularly the colon, exists in a state of physiological hypoxia and during active inflammation, this hypoxic state is enhanced as a result of infiltrating leukocyte oxygen consumption and the activation of oxygen consuming enzymes. Most evidence suggests that mucosal hypoxia promotes the active resolution of inflammation through a variety of mechanisms, including extracellular acidification, purine biosynthesis/salvage, the generation of specialized pro-resolving lipid mediators (ie. resolvins) and altered chemokine/cytokine expression. It is now appreciated that infiltrating innate immune cells (neutrophils, eosinophils, macrophages) have an important role in molding the tissue microenvironment to program an active resolution response. Structural or functional dysregulation of this inflammatory microenvironment can result in the loss of tissue homeostasis and ultimately progression toward chronicity. In this review, we will discuss how inflammatory hypoxia drives mucosal inflammatory resolution and its impact on other microenvironmental factors that influence resolution

Climate Adaptation and Resiliency Planning for New England Communities: First Steps and Next Steps [Report]

New challenges arise from weather events that are driven by a less stable climate. The key difference between what communities already plan for and climate adaptation planning is the level of uncertainty about how impacts may change in the future and the potentially enormous and devastating damages that a community may sustain. Climate Adaptation and Resiliency Planning for New England Communities: First Steps and Next Steps (2016) presents an overview of that task, with links to the rapidly expanding guidelines and tools available to local governments and a suggested way of thinking about this responsibility as an extension of what local governments are already doing

Climate Adaptation and Resiliency Planning for New England Communities: First Steps and Next Steps

Hurricane Irene tearing Vermont roads and bridges apart and Superstorm Sandy ripping through coastal areas; such phenomenal events are being joined by more frequent rain, tide and wind impacts that are disrupting communities and risking property and lives. New challenges arise from weather events that are driven by a less stable climate. The key difference between what communities already plan for and climate adaptation planning is the level of uncertainty about how impacts may change in the future and the potentially enormous and devastating damages that a community may sustain. This Guide presents an overview of that task, with links to the rapidly expanding guidelines and tools available to local governments and a suggested way of thinking about this responsibility as an extension of what local governments are already doing

Economic Development and Maine’s Sustainability Solutions Initiative

The authors discuss how Maine’s Sustainability Solu­tions Initiative (SSI) can contribute to economic devel­opment in the state. SSI research is covering five of the seven targeted technology areas identified in recent reports as being important for economic development in the state (forestry and agriculture, environmental, information, composites, marine and aquaculture). The authors note how the broad scope of research carried out through SSI provides opportunities to catalyze new commercial opportunities. As important, SSI is providing many students with a unique learn­ing environment that will prepare them for the new knowledge-based economy

Tax Policy and Economic Development: A Roundtable Assessment

Economic development continues to be a top policy issue for the state of Maine. Within the broad topic of economic development is the issue of tax policy, and the state continues to experiment with changes in traditional taxes, such as sales and income, as well as with newer approaches, such as Employment Tax Increment Financing. What works and what does not work? Can the state afford the potential loss of revenues associated with tax incentives? Who wins and who loses from these policies? To answer these questions, Maine Policy Review convened a panel of experts to review Maine’s record. Two represent state government and have been involved directly in the administration of tax incentives, Brian Mahany and Alan P. Brigham. They are joined by two policy analysts with expertise in economic development, Christopher Kit St. John and Charles Colgan. There is a surprising degree of consensus about the inevitability of tax incentives and the value of their judicious application. Yet, it also is clear that they are not the centerpiece of economic development policy, and their impacts on the equitable distribution of public funds must be monitored

Spitzer observations of extragalactic H II regions - III. NGC 6822 and the hot star, H II region connection

Using the short-high module of the Infrared Spectrograph on the Spitzer Space Telescope, we have measured the [S IV] 10.51, [Ne II] 12.81, [Ne III] 15.56, and [S III] 18.71-micron emission lines in nine H II regions in the dwarf irregular galaxy NGC 6822. These lines arise from the dominant ionization states of the elements neon (Ne$^{++}$, Ne$^+$) and sulphur (S$^{3+}$, S$^{++}$), thereby allowing an analysis of the neon to sulphur abundance ratio as well as the ionic abundance ratios Ne$^+$/Ne$^{++}$ and S$^{3+}$/S$^{++}$. By extending our studies of H II regions in M83 and M33 to the lower metallicity NGC 6822, we increase the reliability of the estimated Ne/S ratio. We find that the Ne/S ratio appears to be fairly universal, with not much variation about the ratio found for NGC 6822: the median (average) Ne/S ratio equals 11.6 (12.2$\pm$0.8). This value is in contrast to Asplund et al.'s currently best estimated value for the Sun: Ne/S = 6.5. In addition, we continue to test the predicted ionizing spectral energy distributions (SEDs) from various stellar atmosphere models by comparing model nebulae computed with these SEDs as inputs to our observational data, changing just the stellar atmosphere model abundances. Here we employ a new grid of SEDs computed with different metallicities: Solar, 0.4 Solar, and 0.1 Solar. As expected, these changes to the SED show similar trends to those seen upon changing just the nebular gas metallicities in our plasma simulations: lower metallicity results in higher ionization. This trend agrees with the observations.Comment: 22 pages, 13 figures. To be published in MNRAS. reference added and typos fixed. arXiv admin note: text overlap with arXiv:0804.0828, which is paper II by Rubin et al. (2008