Collisional equilibrium, particle production and the inflationary universe

Particle production processes in the expanding universe are described within a simple kinetic model. The equilibrium conditions for a Maxwell-Boltzmann gas with variable particle number are investigated. We find that radiation and nonrelativistic matter may be in equilibrium at the same temperature provided the matter particles are created at a rate that is half the expansion rate. Using the fact that the creation of particles is dynamically equivalent to a nonvanishing bulk pressure we calculate the backreaction of this process on the cosmological dynamics. It turns out that the `adiabatic' creation of massive particles with an equilibrium distribution for the latter necessarily implies power-law inflation. Exponential inflation in this context is shown to become inconsistent with the second law of thermodynamics after a time interval of the order of the Hubble time.Comment: 19 pages, latex, no figures, to appear in Phys.Rev.

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notablesuccesses in some cancers; however, significant problems remain with this approach. Many targetedtherapies are highly toxic, costs are extremely high, and most patients experience relapse after a fewdisease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistantimmortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are notreliant upon the same mechanisms as those which have been targeted). To address these limitations, aninternational task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspectsof relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a widerange of high-priority targets (74 in total) that could be modified to improve patient outcomes. For thesetargets, corresponding low-toxicity therapeutic approaches were then suggested, many of which werephytochemicals. Proposed actions on each target and all of the approaches were further reviewed forknown effects on other hallmark areas and the tumor microenvironment. Potential contrary or procar-cinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixedevidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of therelationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. Thisnovel approach has potential to be relatively inexpensive, it should help us address stages and types ofcancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for futureresearch is offered