Development of a new diagnostic device for extracorporeal shock-wave lithotripsy

Extracorporeal Shock-Wave Lithotripsy (ESWL) is the leading technique for the non-invasive treatment of urinary stones. Thousands of ultrasound shocks are focused on the stones in order to break them into fragments small enough to be passed naturally by the body. The procedure is well established, though the re-treatment rate is around 50%. One of the limits of the procedure is that there is no capability for on-line monitoring of the degree of fragmentation of the stone. The output of the treatments could probably be improved if this facility was made available. The underlying physical mechanisms responsible for the break-up of the stone are still subject to investigation. However both direct stress damage and indirect cavitation erosion seem to be necessary to obtain eliminable fragments. In previous studies, Coleman et al. monitored cavitation in-vivo through the associated acoustic emissions. The objective of this research was to design a new diagnostic device for lithotripsy, exploiting the information carried by these acoustic emissions. After preliminary laboratory experiments some clinical prototypes were developed in collaboration with Precision Acoustic Ltd., UK. The prototypes are currently been tested in the clinic

Double-blind comparative trial of parenteral lorazepam and papaveretum in premedication

Lorazepam, a new sedative drug of the benzodiazepine group, was compared in a double-blind study with a papaveretumjhyoscine mixture in a series of 50 patients awaiting surgery. No difference between the drugs in terms of sedation or side-effects was detected.S. Afr. Med. J., 48, 862 (1974)

Atomic Model of Susy Hubbard Operators

We apply the recently proposed susy Hubbard operators to an atomic model. In the limiting case of free spins, we derive exact results for the entropy which are compared with a mean field + gaussian corrections description. We show how these results can be extended to the case of charge fluctuations and calculate exact results for the partition function, free energy and heat capacity of an atomic model for some simple examples. Wavefunctions of possible states are listed. We compare the accuracy of large N expansions of the susy spin operators with those obtained using `Schwinger bosons' and `Abrikosov pseudo-fermions'. For the atomic model, we compare results of slave boson, slave fermion, and susy Hubbard operator approximations in the physically interesting but uncontrolled limiting case of N->2. For a mixed representation of spins we estimate the accuracy of large N expansions of the atomic model. In the single box limit, we find that the lowest energy saddle-point solution reduces to simply either slave bosons or slave fermions, while for higher boxes this is not the case. The highest energy saddle-point solution has the interesting feature that it admits a small region of a mixed representation, which bears a superficial resemblance to that seen experimentally close to an antiferromagnetic quantum critical point.Comment: 17 pages + 7 pages Appendices, 14 figures. Substantial revision

The spatial distribution of cavitation induced acoustic emission, sonoluminescence and cell lysis in the field of a shock wave lithotripter

This study examines the spatial distribution of various properties attributed to the cavitation field generated by a shock wave lithotripter. These properties include acoustic emission and sonoluminescence, which result from violent bubble collapse, and the degree of cell lysis in vitro, which appears to be related to cavitation. The acoustic emission detected with a 1 MHz, 12 cm diameter focused hydrophone occurs in two distinct bursts. The immediate signal is emitted from a small region contained within the 4 MPa peak negative pressure contour. A second, delayed, burst is emitted from a region extending further along the beam axis. The delay between these two bursts has also been mapped, and the longest delay occurs at positions close to the regions of maximum peak negative pressure. Sonoluminescence from both single and multiple shocks occurs in a broader region than the acoustic emission but the measurement technique does not allow time resolution of the signal. Cell lysis occurs in a relatively small region that correlates closely with the immediate acoustic emission for a shock propagating in a gelatine solution

Ketamine and the obstetric patient

Ketamine anaesthesia was administered to 135 mothers undergoing Caesarean section. The incidence of awareness, dream recall, and psychic disturbance in this group was compared with that occurring in 126 subjects anaesthetised with thiopentone and nitrous oxide. Factual recall was rare in both groups. Dreaming, although more frequent in the ketamine series, was usually pleasant in nature. Psychic phenomena occurred after ketamine anaesthesia, but were infrequent if ketamine dosage was limited, or anaesthesia supplemented with diazepam. It is concluded that ketamine may be used to advantage in obstetric anaesthesia, without significant dreaming or psychic disturbances. S. Afr. Med. J., 48, 734 (1974)

General anaesthesia for caesarean section

Fifty mothers presenting for elective Caesarean section were anaesthetised using a technique previously recommended for obstetric anaesthesia. Clinically, most infants were in good condition after birth. Blood gas studies done on the mothers before induction and at delivery showed a mild respiratory alkalosis with a compensatory metabolic acidosis. Mean umbilical arterial blood gas/acid-base status revealed a mild acidaemia, both respiratory and metabolic in origin, which was well within accepted normal limits. Fetal oxygenation also appeared satisfactory (mean umbilical vein p02 33,9 torr and umbilical artery p02 18,9 torr). Two mothers (4%) were conscious during surgery, but felt no pain. Vomiting after anaesthesia occurred in 16% of cases. Evidence of postoperative chest infection was found in 5 mothers (10%). Thus, the anaesthetic technique advocated does not appear to adversely influence the mother or her infant.S. Afr. Med. J., 48, 1735 (1974)

Provenance of the upper Eocene Castle Rock Conglomerate, south Denver Basin, Colorado, U.S.A.

The Castle Rock Conglomerate contains distinctive clasts from the Colorado Front Range, and when combined with detrital zircon ages, the unit can be subdivided into two lithofacies. Precambrian quartzites and stretched-pebble conglomerates from Coal Creek Canyon (to the northwest of the Castle Rock Conglomerate outcrop belt) and detrital zircons from Precambrian and Tertiary igneous rocks identify a northern provenance with detritus derived from tens of kilometers northwest of Denver, Colorado. A second source, composed of mainly granite from the Pikes Peak batholith, lies in the southern Front Range west of the Castle Rock Conglomerate outcrop belt. Both the north and west lithofacies can be mapped in the Castle Rock Conglomerate outcrop belt by using the presence (north) and absence (west) of Coal Creek Canyon quartzite clasts. This distinction is confirmed by detrital zircon ages. The north lithofacies dominates the present-day, northernmost outcrops, but dilution and interbedding with west lithofacies increase as the southeast-flowing basin axial paleodrainage meets piedmont tributaries that carried Pikes Peak batholith detritus from the west and southwest. The basin axial drainage transported coarse conglomerate southward about 120 km during Castle Rock Conglomerate deposition (36.7-34.0 Ma). The Precambrian quartzite exposed in Coal Creek Canyon is interpreted to be an important point source that can be useful in provenance studies of sediments shed from the Colorado Front Range. Additionally, detrital zircons from Laramide-age igneous rocks show potential for improved stratigraphic resolution in Paleogene strata of the Denver Basin

Rurality as a predictor of perinatal mental health and well‐being in an Australian cohort

Objective Perinatal emotional well-being is more than the presence or absence of depressive and anxiety disorders; it encompasses a wide range of factors that contribute to emotional well-being. This study compares perinatal well-being between women living in metropolitan and rural regions. Design Prospective, longitudinal cohort. Participants/setting Eight hundred and six women from Victoria and Western Australia recruited before 20 weeks of pregnancy and followed up to 12 months postpartum. Main outcome measures Rurality was assessed using the Modified Monash Model (MM Model) with 578 in metropolitan cities MM1, 185 in regional and large rural towns MM2-MM3 and 43 in rural to remote MM4-MM7. The Structured Clinical Interview for DSM-IV (SCID-IV) was administered at recruitment to assess depression, and symptoms of depression and anxiety were measured using the Edinburgh Post-natal Depression Scale and the State and Trait Anxiety Scale, respectively. Other measures included stressful events, diet, exercise, partner support, parenting and sleep. Results The prevalence of depressive disorders did not differ across rurality. There was also no difference in breastfeeding cessation, exercise, sleep or partner support. Women living in rural communities and who also had depression reported significantly higher parenting stress than metropolitan women and lower access to parenting activities. Conclusions Our study suggests while many of the challenges of the perinatal period were shared between women in all areas, there were important differences in parenting stress and access to activities. Furthermore, these findings suggest that guidelines and interventions designed for perinatal mental health should consider rurality

Cosmological Constant, Gauge Hierarchy and Warped Geometry

It is suggested that the mechanism responsible for the resolution of the gauge hierarchy problem within the warped geometry framework can be generalized to provide a new explanation of the extremely tiny vacuum energy density rho_V suggested by recent observations. We illustrate the mechanism with some 5D examples in which the true vacuum energy is assumed to vanish, and rho_V is associated with a false vacuum energy such that rho_V^{1/4} ~ TeV^2/M_{Pl} ~ 10^{-3} eV, where M_{Pl} denotes the reduced Planck mass. We also consider a quintessence-like solution to the dark energy problem.Comment: 10 pages, LaTeX, 2 figures, section on quantum corrections added, version to appear in Phys. Rev.