The genomics of neonatal abstinence syndrome

Significant variability has been observed in the development and severity of neonatal abstinence syndrome (NAS) among neonates exposed to prenatal opioids. Since maternal opioid dose does not appear to correlate directly with neonatal outcome, maternal, placental, and fetal genomic variants may play important roles in NAS. Previous studies in small cohorts have demonstrated associations of variants in maternal and infant genes that encode the μ-opioid receptor (OPRM1), catechol-O-methyltransferase (COMT), and prepronociceptin (PNOC) with a shorter length of hospital stay and less need for treatment in neonates exposed to opioids in utero. Consistently falling genomic sequencing costs and computational approaches to predict variant function will permit unbiased discovery of genomic variants and gene pathways associated with differences in maternal and fetal opioid pharmacokinetics and pharmacodynamics and with placental opioid transport and metabolism. Discovery of pathogenic variants should permit better delineation of the risk of developing more severe forms of NAS. This review provides a summary of the current role of genomic factors in the development of NAS and suggests strategies for further genomic discovery

Correlation Between the Halo Concentration (c) and the Virial Mass (Mvir) Determined from X-ray Clusters

Numerical simulations of structure formation have suggested that there exists a good correlation between the halo concentration c (or the characteristic density delta_c) and the virial mass Mvir for any virialized dark halo described by the Navarro, Frenk & White (1995) density profile. In this Letter, we present an observational determination of the c-Mvir (or delta_c-Mvir) relation in the mass range of 10^14< Mvir <10^16 (solar mass) using a sample of 63 X-ray luminous clusters. The best-fit power law relation, which is roughly independent of the values of Omega_M and Lambda, is c propto Mvir^(-0.5) or delta_c propto Mvir^(-1.2), indicating n=-0.7 for a scale-free power spectrum of the primordial density fluctuations. We discuss the possible reasons for the conflict with the predictions by typical CDM models such as SCDM, LCDM and OCDM.Comment: 13 pages, 1 figure, two tables. Accepted for publication in ApJ

Wide Angle Redshift Distortions Revisited

We explore linear redshift distortions in wide angle surveys from the point of view of symmetries. We show that the redshift space two-point correlation function can be expanded into tripolar spherical harmonics of zero total angular momentum $S_{l_1 l_2 l_3}(\hat x_1, \hat x_2, \hat x)$. The coefficients of the expansion $B_{l_1 l_2 l_3}$ are analogous to the $C_l$'s of the angular power spectrum, and express the anisotropy of the redshift space correlation function. Moreover, only a handful of $B_{l_1 l_2 l_3}$ are non-zero: the resulting formulae reveal a hidden simplicity comparable to distant observer limit. The $B_{l_1 l_2 l_3}$ depend on spherical Bessel moments of the power spectrum and $f = \Omega^{0.6}/b$. In the plane parallel limit, the results of \cite{Kaiser1987} and \cite{Hamilton1993} are recovered. The general formalism is used to derive useful new expressions. We present a particularly simple trigonometric polynomial expansion, which is arguably the most compact expression of wide angle redshift distortions. These formulae are suitable to inversion due to the orthogonality of the basis functions. An alternative Legendre polynomial expansion was obtained as well. This can be shown to be equivalent to the results of \cite{SzalayEtal1998}. The simplicity of the underlying theory will admit similar calculations for higher order statistics as well.Comment: 6 pages, 1 figure, ApJL submitte

Propulsion system mathematical model for a lift/cruise fan V/STOL aircraft

A propulsion system mathematical model is documented that allows calculation of internal engine parameters during transient operation. A non-realtime digital computer simulation of the model is presented. It is used to investigate thrust response and modulation requirements as well as the impact of duty cycle on engine life and design criteria. Comparison of simulation results with steady-state cycle deck calculations showed good agreement. The model was developed for a specific 3-fan subsonic V/STOL aircraft application, but it can be adapted for use with any similar lift/cruise V/STOL configuration

APPLICATION OF THE MODULARIZATION CONCEPT TO SATELLITE TAPE RECORDERS

Application of the modularization concept to satellite tape recorder

Structure formation from non-Gaussian initial conditions: multivariate biasing, statistics, and comparison with N-body simulations

We study structure formation in the presence of primordial non-Gaussianity of the local type with parameters f_NL and g_NL. We show that the distribution of dark-matter halos is naturally described by a multivariate bias scheme where the halo overdensity depends not only on the underlying matter density fluctuation delta, but also on the Gaussian part of the primordial gravitational potential phi. This corresponds to a non-local bias scheme in terms of delta only. We derive the coefficients of the bias expansion as a function of the halo mass by applying the peak-background split to common parametrizations for the halo mass function in the non-Gaussian scenario. We then compute the halo power spectrum and halo-matter cross spectrum in the framework of Eulerian perturbation theory up to third order. Comparing our results against N-body simulations, we find that our model accurately describes the numerical data for wavenumbers k < 0.1-0.3 h/Mpc depending on redshift and halo mass. In our multivariate approach, perturbations in the halo counts trace phi on large scales and this explains why the halo and matter power spectra show different asymptotic trends for k -> 0. This strongly scale-dependent bias originates from terms at leading order in our expansion. This is different from what happens using the standard univariate local bias where the scale-dependent terms come from badly behaved higher-order corrections. On the other hand, our biasing scheme reduces to the usual local bias on smaller scales where |phi| is typically much smaller than the density perturbations. We finally discuss the halo bispectrum in the context of multivariate biasing and show that, due to its strong scale and shape dependence, it is a powerful tool for the detection of primordial non-Gaussianity from future galaxy surveys.Comment: 26 pages, 16 figures. Minor modifications, version accepted by Phys. Rev.

The cosmological origin of the Tully-Fisher relation

We use high-resolution cosmological simulations that include the effects of gasdynamics and star formation to investigate the origin of the Tully-Fisher relation in the standard Cold Dark Matter cosmogony. Luminosities are computed for each model galaxy using their full star formation histories and the latest spectrophotometric models. We find that at z=0 the stellar mass of model galaxies is proportional to the total baryonic mass within the virial radius of their surrounding halos. Circular velocity then correlates tightly with the total luminosity of the galaxy, reflecting the equivalence between mass and circular velocity of systems identified in a cosmological context. The slope of the relation steepens slightly from the red to the blue bandpasses, and is in fairly good agreement with observations. Its scatter is small, decreasing from \~0.45 mag in the U-band to ~0.34 mag in the K-band. The particular cosmological model we explore here seems unable to account for the zero-point of the correlation. Model galaxies are too faint at z=0 (by about two magnitudes) if the circular velocity at the edge of the luminous galaxy is used as an estimator of the rotation speed. The Tully-Fisher relation is brighter in the past, by about ~0.7 magnitudes in the B-band at z=1, at odds with recent observations of z~1 galaxies. We conclude that the slope and tightness of the Tully-Fisher relation can be naturally explained in hierarchical models but that its normalization and evolution depend strongly on the star formation algorithm chosen and on the cosmological parameters that determine the universal baryon fraction and the time of assembly of galaxies of different mass.Comment: 5 pages, 4 figures included, submitted to ApJ (Letters

Majorana spinors and extended Lorentz symmetry in four-dimensional theory

An extended local Lorentz symmetry in four-dimensional (4D) theory is considered. A source of this symmetry is a group of general linear transformations of four-component Majorana spinors GL(4,M) which is isomorphic to GL(4,R) and is the covering of an extended Lorentz group in a 6D Minkowski space M(3,3) including superluminal and scaling transformations. Physical space-time is assumed to be a 4D pseudo-Riemannian manifold. To connect the extended Lorentz symmetry in the M(3,3) space with the physical space-time, a fiber bundle over the 4D manifold is introduced with M(3,3) as a typical fiber. The action is constructed which is invariant with respect to both general 4D coordinate and local GL(4,M) spinor transformations. The components of the metric on the 6D fiber are expressed in terms of the 4D pseudo-Riemannian metric and two extra complex fields: 4D vector and scalar ones. These extra fields describe in the general case massive particles interacting with an extra U(1) gauge field and weakly interacting with ordinary particles, i.e. possessing properties of invisible (dark) matter.Comment: 24 page

Dark-Halo Cusp: Asymptotic Convergence

We propose a model for how the buildup of dark halos by merging satellites produces a characteristic inner cusp, of a density profile \rho \prop r^-a with a -> a_as > 1, as seen in cosmological N-body simulations of hierarchical clustering scenarios. Dekel, Devor & Hetzroni (2003) argue that a flat core of a<1 exerts tidal compression which prevents local deposit of satellite material; the satellite sinks intact into the halo center thus causing a rapid steepening to a>1. Using merger N-body simulations, we learn that this cusp is stable under a sequence of mergers, and derive a practical tidal mass-transfer recipe in regions where the local slope of the halo profile is a>1. According to this recipe, the ratio of mean densities of halo and initial satellite within the tidal radius equals a given function psi(a), which is significantly smaller than unity (compared to being 1 according to crude resonance criteria) and is a decreasing function of a. This decrease makes the tidal mass transfer relatively more efficient at larger a, which means steepening when a is small and flattening when a is large, thus causing converges to a stable solution. Given this mass-transfer recipe, linear perturbation analysis, supported by toy simulations, shows that a sequence of cosmological mergers with homologous satellites slowly leads to a fixed-point cusp with an asymptotic slope a_as>1. The slope depends only weakly on the fluctuation power spectrum, in agreement with cosmological simulations. During a long interim period the profile has an NFW-like shape, with a cusp of 1<a<a_as. Thus, a cusp is enforced if enough compact satellite remnants make it intact into the inner halo. In order to maintain a flat core, satellites must be disrupted outside the core, possibly as a result of a modest puffing up due to baryonic feedback.Comment: 37 pages, Latex, aastex.cls, revised, ApJ, 588, in pres

Analytical modeling of the structureborne noise path on a small twin-engine aircraft

The structureborne noise path of a six passenger twin-engine aircraft is analyzed. Models of the wing and fuselage structures as well as the interior acoustic space of the cabin are developed and used to evaluate sensitivity to structural and acoustic parameters. Different modeling approaches are used to examine aspects of the structureborne path. These approaches are guided by a number of considerations including the geometry of the structures, the frequency range of interest, and the tractability of the computations. Results of these approaches are compared with experimental data