Can unilateral, progressive or sudden hearing loss be immune-mediated in origin?

OBJECTIVE: The aim of the present study was to demonstrate that the positivity of nonspecific immunological tests could be found not only in bilateral hearing loss but also in unilateral cases, either sudden or progressive. METHOD: An observational case series study included subjects suffering from unilateral or bilateral, sudden or progressive, symmetric or asymmetric sensorineural hearing loss (SNHL). All the patients underwent pure tone audiometry and the following battery of blood exams: anti-nuclear antibody (ANA), extractable nuclear antigen (ENA) antibody screening, anti-thyroperoxidase (anti-TPO), anti-thyroglobulin and anti-smooth muscle antibody (ASMA). RESULTS: The positivity to nonspecific immunological test was found in nearly 70% of the study groups. ASMA and ANA were found to be present in both bilateral and unilateral cases, without statistical difference. Considering the correlation between positivity/negativity and systemic autoimmune pathologies, in the bilateral forms of hearing loss, a high incidence of thyroid pathologies has been identified, with a higher percentage of systemic autoimmune diseases in respect to the normal population. CONCLUSIONS: The nonspecific autoimmune tests are worth to be performed also when SNHL is not bilateral and progressive, since an immunological mechanism could also underlie unilateral and sudden SNHL cases

The SiC problem: astronomical and meteoritic evidence

Pre-solar grains of silicon carbide found in meteorites and interpreted as having had an origin around carbon stars from their isotopic composition, have all been found to be of the beta-SiC polytype. Yet to date fits to the 11.3 microns SiC emission band of carbon stars had been obtained only for alpha-SiC grains. We present thin film infrared (IR) absorption spectra measured in a diamond anvil cell for both the alpha- and beta- polymorphs of synthetic SiC and compare the results with previously published spectra taken using the KBr matrix method. We find that our thin film spectra have positions nearly identical to those obtained previously from finely ground samples in KBr. Hence, we show that this discrepancy has arisen from inappropriate `KBr corrections' having been made to laboratory spectra of SiC particles dispersed in KBr matrices. We re-fit a sample of carbon star mid-IR spectra, using laboratory data with no KBr correction applied, and show that beta-SiC grains fit the observations, while alpha-SiC grains do not. The discrepancy between meteoritic and astronomical identifications of the SiC-type is therefore removed. This work shows that the diamond anvil cell thin film method can be used to produce mineral spectra applicable to cosmic environments without further manipulation.Comment: to be published in Astrophysical Journal Letter 4 pages, 3 figure

Nonequilibrium Response from the dissipative Liouville Equation

The problem of response of nonequilibrium systems is currently under intense investigation. We propose a general method of solution of the Liouville Equation for thermostatted particle systems subjected to external forces which retains only the slow degrees of freedom, by projecting out the majority of fast variables. Response formulae, extending the Green-Kubo relations to dissipative dynamics are provided, and comparison with numerical data is presented

GaN LNAs for Robust Receiving Systems in Radar and Space Applications

In this contribution a series of integrated circuits and methodologies, purposely developed for application in microwave receiving subsystems, will be presented. The integrated circuits, realized in GaN integrated technologies by different suppliers, find their applications in telecom systems as well as in RADAR ones, mainly for space-based apparatuses. The respective performance, as well as the key design methods will be presented in the contribution for bandwidths ranging from S-Band up to K-Band

Estimated optical constants of gypsum in the regions of weak absorptions: Application of scattering theories and comparisons to independent measurements

Diffuse reflectance spectra of multiple grain size fractions are used to estimate the optical constants of gypsum over the 0.4–15 μm wavelength region. Two independent scattering theories are used to iteratively determine the imaginary index of refraction from the measured reflectance. We compare the results of these two with each other and with imaginary indices of gypsum reported in the literature. We find that the scattering theory results are more sensitive in the infrared to weak spectral features that are clearly distinguished in the diffuse reflectance spectra. However, we find the scattering results provide a poor determination of the optical constants in the regions of relatively strong absorptions. At visible and near-infrared wavelengths we provide a comparison to the results obtained from analysis of the diffuse reflectance to results obtained from direct transmission measurements of several gypsum crystals having different sample thicknesses. We find the simplest models of the transmission reproduce the observed spectra. The different sample thicknesses for the transmission measurements and different grain sizes in the scattering theories allow evaluation of the imaginary index of refraction over a wide range of values. We find the imaginary index of refraction determined from scattering theories is in remarkable agreement with those obtained from transmission spectra. Different models of the reflectance and transmittance have associated strengths and weaknesses, and we conclude that combining these models provides a more accurate determination of the optical constants of a material when compared to using each separately. We combine the resulting real and imaginary indices of refraction with those reported at infrared wavelengths to provide values covering visual, near-infrared, and infrared wavelengths (0.4–333 μm, 25000–30 cm^(−1))

A New Measurement of the Average FUV Extinction Curve

We have measured the extinction curve in the far-ultraviolet wavelength region of (900 -- 1200 A) using spectra obtained with the Berkeley EUV/FUV spectrometer during the ORFEUS-I and the ORFEUS-II missions in 1993 and 1996. From the complete sample of early-type stars observed during these missions, we have selected pairs of stars with the same spectral type but different reddenings to measure the differential FUV extinction. We model the effects of molecular hydrogen absorption and exclude affected regions of the spectrum to determine the extinction from dust alone. We minimize errors from inaccuracies in the cataloged spectral types of the stars by making our own determinations of spectral types based on their IUE spectra. We find substantial scatter in the curves of individual star pairs and present a detailed examination of the uncertainties and their effects on each extinction curve. We find that, given the potentially large uncertainties inherent in using the pair method at FUV wavelengths, a careful analysis of measurement uncertainties is critical to assessing the true dust extinction. We present a new measurement of the average far-ultraviolet extinction curve to the Lyman limit; our new measurement is consistent with an extrapolation of the standard extinction curve of Savage & Mathis (1979).Comment: 13 pages text, 7 figures 4 tables. Sent as gzipped tar, with ms.tex and 7 figure

Linear characterization and modeling of GaN-on-Si HEMT technologies with 100 nm and 60 nm gate lengths

Motivated by the growing interest towards low-cost, restriction-free MMIC processes suitable for multi-function, possibly space-qualified applications, this contribution reports the extraction of reliable linear models for two advanced GaN-on-Si HEMT technologies, namely OMMIC’s D01GH (100 nm gate length) and D006GH (60 nm gate length). This objective is pursued by means of both classical and more novel approaches. In particular, the latter include a nondestructive method for determining the extrinsic resistances and an optimizaion-based approach to extracting the remaining parasitic elements: these support standard DC and RF measurements in order to obtain a scalable, bias-dependent equivalent-circuit model capturing the small-signal behavior of the two processes. As to the noise model, this is extracted by applying the well known noise-temperature approach to noise figure measurements performed in two different frequency ranges: a lower band, where a standard Y-factor test bench is used, and an upper band, where a custom cold-source test bench is set up and described in great detail. At 5 V drain-source voltage, minimum noise figures as low as 1.5 dB and 1.1 dB at 40 GHz have been extracted for the considered 100 nm and 60 nm HEMTs, respectively: this testifies the maturity of both processes and the effectiveness of the gate length reduction. The characterization and modeling campaign, here presented for the first time, has been repeatedly validated by published designs, a couple of which are reviewed for the Reader’s convenience

Analysis of cosmic materials: Results on carbon and silicate laboratory analogues

Carbon and silicates are two of the main components of cosmic dust. They change nature through different evolutionary phases, according to the cosmic environment and the experienced processing. To understand the evolution of cosmic materials the study of "laboratory analogues" represents a powerful tool. In this context, systematic analyses are performed at the cosmic physics laboratory of Naples on solid particles, synthesised and processed under carefully controlled conditions. Different kinds of carbon and silicate samples are produced under various environmental conditions and exposed to processes (e.g. thermal annealing, UV irradiation and ion bombardment). The comparative analysis of the results allows us to link intrinsic properties (such as chemical composition and structure) to the optical behaviour of grains. This study offers the opportunity to interpret observations concerning the composition of small bodies in the Solar System, such as spectroscopic results obtained for comets by the Infrared Space Observatory (ISO). Several open questions remain, however, unsolved and await results from new laboratory experiments. ©1999 COSPAR. Published by Elsevier Science Ltd

Is minimally-invasive spinal surgery a reliable treatment option in symptomatic spinal metastasis?

OBJECTIVE: Up to 70% of patients with cancer are likely to develop spine metastasis. Radiation therapy is the standard of care for painful spinal metastases in absence of unstable or impending fractures. More frequently these patients require open palliative surgery for pain, vertebral collapse and neurological deficits. Minimally Invasive Spine Surgery (MISS) techniques using percutaneous pedicle screw fixation may be considered as an alternative to open surgery in selected cases. MISS techniques are thought to be associated with fewer tissues damages resulting in early pain relief, they also allow for early mobilization and optimization of function. PATIENTS AND METHODS: From 2011 to 2018, 52 patients affected by spinal metastasis were treated with MISS techniques in Rizzoli Orthopaedic Institute of Bologna and in Cisanello Hospital of Pisa, Italy. All patients underwent percutaneous pedicle screw fixations (PPSF) coupled with mini-decompressions in case it was required by spinal cord compressions. All patients were evaluated pre and post-operatively by Frenkel classification and VAS scores. RESULTS: Mean follow-up time was 19,4 months. Preoperatively, Frankel scores were E in 37 patients, D3 in 6 patients, D2 in 3 cases, D1 in 3 patients, B in one patient and C in two. The Frankel score improved in 10 patients, remained stable in 40 patients and worsened in two patients. Preoperatively, the mean VAS score in 29 patients treated with PPSF procedure with spinal decompression was 7, while postoperatively, it became 5. In 23 patients who underwent only PPSF procedure without spinal decompression mean VAS score was 5, postoperatively it became 3. CONCLUSIONS: In selected cases, MISS surgeries may be considered as a valid alternative to open surgery. Although the efficacy of PPSF has been well documented in trauma or degenerative spine surgery, there is not sufficient literature about MISS techniques in spinal metastasis and further studies are needed to elucidate the most appropriate patient in which this approach could represent the gold standard of treatment