Saliva resistin as a screening marker of gestational diabetes mellitus

GURLEK, BERIL/0000-0002-4050-3193WOS: 000559871000001PubMed: 32804001Objective the aim of this study was to evaluate the resistin concentrations in saliva; which is a noninvasive and stress-free diagnostic sample, and to investigate the significance of salivary resistin concentrations in screening GDM. Methods This cross-sectional case-control study included 41 newly diagnosed GDM patients and 40 healthy pregnant. the participants were consecutively included in the study among eligible pregnant women; who were in the age range from 18 to 40 years of age and at the gestational age between 24 and 28 weeks. the levels of serum and salivary resistin were determined using an enzyme-linked immunosorbent assay method. Results Maternal serum resistin and salivary resistin concentrations were significantly higher in the patients with GDM compared to the individuals in the control group. the data were evaluated by the receiver-operator curve analysis; which revealed that serum and saliva resistin concentrations were moderately successful markers to differentiate subjects with GDM from healthy pregnant women. Conclusions the results indicate that the determination of saliva resistin levels at the gestational age between 24 to 28 weeks may be used as an alternative, stress-free, and noninvasive technique that may be used in GDM screening.Recep Tayyip Erdogan University's Scientific Research Committee [TSA-2019-968]This work was financially supported by the grant [number TSA-2019-968] received from Recep Tayyip Erdogan University's Scientific Research Committee

Cystic Endometriosis in a Huge Degenerated Subserous Leiomyoma Mimicking Bilateral Multicystic Endometriomas in an Infertile Woman with Diminished Ovarian Reserve: A Rare Endometriotic Implantation

Uterine leiomyomas are the most common pelvic tumor in women. Leiomyoma can show atypical locations and degenerations and may not be easily differentiated from adnexal masses. Uterine leiomyoma can undergo cystic degeneration and is said to be found in 4% of all types of degenerations. The commonest type of degeneration is hyaline seen in 60% of patients. Usually uterine leiomyoma does not present as clinical and radiological diagnostic challenge. However, when leiomyoma undergoes massive cystic degeneration they may become clinical and radiological diagnostic dilemmas. The MRI showed a huge cystic mass protruding up to the pelvis not differentiated from bilateral endometriomas and accompanying subserous myomas. Surgery revealed that the mass is not bilateral endometriomas but a huge pedunculated leiomyoma with cystic degeneration and cystic endometriosis. Endometriosis is a troubling gynecologic condition occurring in 10% to 15% of women of reproductive age and is associated with fertility problems. As a peritoneal disease, the locations of endometriotic lesions are predominantly the ovaries (96.4%), followed by the soft tissue (2.8%), gastrointestinal tract (0.3%), and urinary tract (0.2%) and other rare locations. The presented case is multiple sized cystic endometriosis (endometriomas) located in a huge pedunculated subserous leiomyoma in an infertile woman having a history of laparoscopic bilateral endometrioma surgery. Conclusion. To our knowledge, this is the first reported case for endometriotic cysts (endometriomas) located in a huge cystic degenerated leiomyoma. PubMed search revealed no report concerning endometriotic implantation in the leiomyomas

Investigating fear of childbirth in pregnant women and its relationship between anxiety sensitivity and somatosensory amplification

WOS: 000527818200001PubMed: 32314633The causes of fear of childbirth and the factors that affect it are not fully explained. the aim of this study was to investigate the relationship between fear of childbirth in pregnant women and anxiety sensitivity and somatosensory amplification. the study included 100 healthy pregnant women who were admitted to the Obstetrics and Gynaecology Department of a tertiary hospital in Turkey at 28-40 weeks of gestation. Sociodemographic Data Form, Anxiety Sensitivity Index (ASI), Somatosensory Amplification Scale (SSAS), Spielberger State and Trait Anxiety Inventory (STAI), Wijma Expectancy/Experience Scale (W-DEQ) were applied to all cases. the mean age of the pregnant women included in the study was 29.20 +/- 6.17 years, and 82% of them had high fear of childbirth. It was determined that factors such as age, education status, occupation, prior pregnancy experience, the number of pregnancies, miscarriage history, and abortion experience had no significant effect on the fear of childbirth. It was observed that there was a weak positive correlation between the fear of childbirth and the anxiety sensitivity and the amplification of somatosensory symptoms. According to the findings of our study, as the fear of childbirth increases, anxiety sensitivity, and somatosensory amplification increase. For this reason, it is crucial to carefully monitor prenatal anxiety, somatosensory amplification and the fear of childbirth of pregnant women with state-related concerns.IMPACT STATEMENT What is already known on this subject? Fear of childbirth or what is historically referred to as tokophobia is generally defined as a fear of severe birth and fear of pathological birth. the causes of fear of childbirth are stated as biological reasons, psychological reasons and lack of social support. However, it is not possible to explain the causes of the fear of childbirth in pregnant women and the risk factors affecting them. Similarly, fear of childbirth in individuals with anxiety sensitivity and amplification of somatosensory symptoms has not been adequately investigated. What do the results of this study add? in this study, we aimed to contribute to the related literature by examining the relationship between fear of childbirth in pregnant women and anxiety sensitivity and amplification of somatosensory symptoms. It was observed that there was a weak positive correlation between the fear of childbirth and the sensitivity of anxiety and the amplification of somatosensory symptoms. According to the findings of our study, as the fear of childbirth increases, anxiety sensitivity, and somatosensory amplification increase. What are the implications of these findings for clinical practice and/or further research? For this reason, it is crucial to carefully monitor the pregnants who have prenatal anxiety sensitivity, somatosensory amplification, and state-continuous anxiety. Due to insufficient number of studies related to the subject, extensive sample studies on the subject are needed

Investigating fear of childbirth in pregnant women and its relationship between anxiety sensitivity and somatosensory amplification

The causes of fear of childbirth and the factors that affect it are not fully explained. The aim of this study was to investigate the relationship between fear of childbirth in pregnant women and anxiety sensitivity and somatosensory amplification. The study included 100 healthy pregnant women who were admitted to the Obstetrics and Gynaecology Department of a tertiary hospital in Turkey at 28–40 weeks of gestation. Sociodemographic Data Form, Anxiety Sensitivity Index (ASI), Somatosensory Amplification Scale (SSAS), Spielberger State and Trait Anxiety Inventory (STAI), Wijma Expectancy/Experience Scale (W-DEQ) were applied to all cases. The mean age of the pregnant women included in the study was 29.20 ± 6.17 years, and 82% of them had high fear of childbirth. It was determined that factors such as age, education status, occupation, prior pregnancy experience, the number of pregnancies, miscarriage history, and abortion experience had no significant effect on the fear of childbirth. It was observed that there was a weak positive correlation between the fear of childbirth and the anxiety sensitivity and the amplification of somatosensory symptoms. According to the findings of our study, as the fear of childbirth increases, anxiety sensitivity, and somatosensory amplification increase. For this reason, it is crucial to carefully monitor prenatal anxiety, somatosensory amplification and the fear of childbirth of pregnant women with state-related concerns.IMPACT STATEMENT What is already known on this subject? Fear of childbirth or what is historically referred to as tokophobia is generally defined as a fear of severe birth and fear of pathological birth. The causes of fear of childbirth are stated as biological reasons, psychological reasons and lack of social support. However, it is not possible to explain the causes of the fear of childbirth in pregnant women and the risk factors affecting them. Similarly, fear of childbirth in individuals with anxiety sensitivity and amplification of somatosensory symptoms has not been adequately investigated. What do the results of this study add? In this study, we aimed to contribute to the related literature by examining the relationship between fear of childbirth in pregnant women and anxiety sensitivity and amplification of somatosensory symptoms. It was observed that there was a weak positive correlation between the fear of childbirth and the sensitivity of anxiety and the amplification of somatosensory symptoms. According to the findings of our study, as the fear of childbirth increases, anxiety sensitivity, and somatosensory amplification increase. What are the implications of these findings for clinical practice and/or further research? For this reason, it is crucial to carefully monitor the pregnants who have prenatal anxiety sensitivity, somatosensory amplification, and state-continuous anxiety. Due to insufficient number of studies related to the subject, extensive sample studies on the subject are needed

Evaluation of sleep-wakefulness disorders in healthcare professionals working at a university hospital during COVID-19

BACKGROUND: The COVID-19 pandemic has impaired the sleep-wakefulness cycle especially of healthcare professionals (HP). Sleep is affected by many factors and preventable risk factors protect HP from sleep disorders. To evaluate sleep quality and sleep disorders in HP working to gain insight risk factors and to raise awareness about working risk groups. MATERIAL AND METHODS: The study population consisted of a total of 1190 HP employed at a hospital during the COVID-19 pandemic. From this population, a sample of 110 HP was selected based on reported only complaints of sleep. A sociodemographic data form and subjective sleep-wakefulness scales were applied. Sleep disorder was evaluated according to the ICSD-3. RESULTS: Most of the participants were female. It was observed that 67.3%of the HP had disturbed sleep quality, and that nurses and medical secretaries had more complaints compared to doctors. Insomnia disorders was the most common disorder among the participants. Cases of insomnia disorders were found to be 15.477 times higher among those who had a history of mental disorders in their families, smoking was shown to have the most negative effect on biological rhythm, and married people experienced more sleepiness during the day. CONCLUSIONS During the COVID-19 pandemic, ancillary health staff is at greater risk of experiencing deterioration of sleep quality and insomnia disorders. Female, being married, cigarette smoking, and family history of psychiatric disorders were correlated with the development of sleep complaints

Protective effects of nebivolol on ovarian ischemia-reperfusion injury in rat

WOS: 000571662500001PubMed: 32961615Aim Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in experimental ischemic (I) and ischemic-reperfusion (I/R) injury in rat ovaries. Methods Forty-eight adult female rats were randomly separated into six groups as group 1 (control) receiving an oral saline solution for 3 days; group 2 (I) that underwent ischemia for 3 h with the application of atraumatic vascular clips; group 3 (I/R); group 4 (I + NEB) receiving 10 mg/kg NEB by oral gavage 30 min prior to the ischemia induction; group 5 (I/R + NEB) receiving 10 mg/kg NEB, and group 6 (control + NEB) receiving oral 10 mg/kg NEB for 3 days before ischemia induction followed by consequent reperfusion. Ovarian tissue damage was scored by histopathological analysis. Ovarian tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured biochemically. Results the levels of MDA and tumor necrosis factor-alpha (TNF-alpha), and TUNEL assay positivity scores increased in the I and I/R groups. GSH levels decreased in all case groups (P < 0.05). the oral administration of NEB (10 mg/kg) to the I- and I/R-groups reduced the levels of MDA and TNF-alpha and TUNEL assay immunopositivity scores (P < 0.05). GSH levels increased in the treatment groups. Conclusion the current experimental ovarian torsion study suggests a protective role for NEB against I and I/R injury in rat ovaries. NEB may be a novel agent for decreasing ovarian I/R injury.Scientific Research Projects Unit of Recep Tayyip Erdogan University [TSA-2019-1041]This work was supported by Scientific Research Projects Unit of Recep Tayyip Erdogan University (grant numbers TSA-2019-1041)

Maternal Gestational Diabetes and Early Childhood Obesity: A Retrospective Cohort Study

WOS: 000589774400001PubMed: 33146559Background: Recently, childhood obesity has become one of the most serious public health problems in the world. Gestational diabetes mellitus (GDM) is considered a risk factor for childhood overweight and obesity. the study aimed at investigating the relationship between maternal GDM and childhood obesity in children aged from 1 to 3 years. Methods: in this retrospective cohort study, 237 GDM and 296 non-GDM mothers and their offspring who were followed up by Family Medicine Clinics in Rize province of Turkey were assessed. World Health Organization (WHO) criteria were used for the diagnosis of maternal GDM. Crude and adjusted logistic regression models were calculated for the association of gestational diabetes and childhood overweight/obesity. Gender and age-specific percentile tables were used for the categorization of BMI. Results: Statistical analysis carried out with adjustment for potential confounders (mother's age, educational status, smoking status, BMI, gestational weight gain, children's gender, and gestational birth weight) provided results with an odds ratio of 2.99; 95% CI 1.14-7.94 and 7.77; 95% CI 1.92-31.37 for the impact of gestational diabetes on childhood overweight and obesity at 2 and 3 years of age, respectively. Conclusions: This study found evidence for maternal GDM to cause the risk of early childhood obesity. Therefore, proper intervention strategies are required for this high-risk population

Could platelet distribution width be a predictive marker for unexplained recurrent miscarriage?

WOS: 000339727400009PubMed: 24619190The aim of our study was to evaluate the platelet function in unexplained recurrent miscarriage and to investigate whether any hematologic changes detectable by simple complete blood count have a diagnostic value for the prediction of unexplained recurrent miscarriage. A prospective study based on the comparison of 74 patients with unexplained recurrent first-trimester pregnancy loss with 208 control subjects matched for age. the two groups were compared in terms of platelet indices. There was a significant difference in platelet distribution width in patients with unexplained recurrent miscarriage compared to healthy control subjects. Platelet distribution width values in the patient group were statistically higher (P < 0.001) than the control group. Our study provides an evidence that platelet distribution width gradually increases in women with recurrent miscarriage compared to control group. Patients with unexplained recurrent miscarriage have significantly increased platelet aggregation. This data may provide an empirical rationale for the use of anticoagulants in the management of this clinical condition

Response to: Platelet indices in patients with unexplained recurrent miscarriage; related factors should be considered

WOS: 000340518300006PubMed: 24925348[No abstract available