Mining Made Simple

Students simulate operating an iron mine, from choosing property to writing an environmental impact statement to setting up the mining operation. Chocolate chip cookies (with the chocolate chips representing iron ore) are used for this experiment. Students are challenged to operate the most profitable and environmentally sound mine they can. Educational levels: Middle school, High school

Antiretroviral treatment outcomes in patients who received rifampicin together with nevirapine or efavirenz.

Cape Town TB Conferenc

Extracting the Dark Matter Mass from Single Stage Cascade Decays at the LHC

We explore a variant on the MT2 kinematic variable which enables dark matter mass measurements for simple, one stage, cascade decays. This will prove useful for constraining a subset of supersymmetric processes, or a class of leptophilic dark matter models at the LHC. We investigate the statistical reach of these measurements and discuss which sources of error have the largest effects. For example, we find that using only single stage cascade decays with initial state radiation, a measurement of a 150 GeV dark matter candidate can be made to O(10%) for a parent mass of 300 GeV with a production cross section of 100 fb and 100 fb^(-1) of integrated luminosity.Comment: 23 Pages, 14 Figures, 2 Appendice

No Transition Disk? Infrared Excess, PAH, H-2, And X-Rays From The Weak-Lined T Tauri Star DoAr 21

As part of a program to understand disk dispersal and the interplay between circumstellar disks and X-ray emission, we present new high-resolution mid-infrared (IR) imaging, high-resolution optical spectroscopy, and Chandra grating X-ray spectroscopy of the weak-lined T Tauri star DoAr 21. DoAr 21 (age \u3c 10(6) yr and mass similar to 2.2M(circle dot) based on evolutionary tracks) is a strong X-ray emitter, with conflicting evidence in the literature about its disk properties. It shows weak but broad H alpha emission (reported here for the first time since the 1950s); polarimetric variability; polycyclic aromatic hydrocarbon (PAH) and H-2 emission; and a strong, spatially resolved 24 mu m excess in archival Spitzer photometry. Gemini sub-arcsecond-resolution 9-18 mu m images show that there is little or no excess mid-IR emission within 100 AU of the star; the excess emission is extended over several arcseconds and is quite asymmetric. The extended emission is bright in the ultraviolet (UV)-excited lambda = 11.3 mu m PAH emission feature. A new high-resolution X-ray grating spectrum from Chandra shows that the stellar X-ray emission is very hard and dominated by continuum emission; it is well fit by a multi-temperature thermal model, typical of hard coronal sources, and shows no evidence of unusually high densities. A flare during the X-ray observation shows a temperature approaching 10(8) K. We argue that the far-UV emission from the transition region is sufficient to excite the observed extended PAH and continuum emission, and that the H-2 emission may be similarly extended and excited. While this extended emission may be a disk in the final stages of clearing, it also could be more akin to a small-scale photodissociation region than a protoplanetary disk, highlighting both the very young ages (\u3c10(6) yr) at which some stars are found without disks and the extreme radiation environment around even late-type pre-main-sequence stars

The Local Structure of Space-Variant Images

Local image structure is widely used in theories of both machine and biological vision. The form of the differential operators describing this structure for space-invariant images has been well documented (e.g. Koenderink, 1984). Although space-variant coordinates are universally used in mammalian visual systems, the form of the operators in the space-variant domain has received little attention. In this report we derive the form of the most common differential operators and surface characteristics in the space-variant domain and show examples of their use. The operators include the Laplacian, the gradient and the divergence, as well as the fundamental forms of the image treated as a surface. We illustrate the use of these results by deriving the space-variant form of corner detection and image enhancement algorithms. The latter is shown to have interesting properties in the complex log domain, implicitly encoding a variable grid-size integration of the underlying PDE, allowing rapid enhancement of large scale peripheral features while preserving high spatial frequencies in the fovea.Office of Naval Research (N00014-95-I-0409

Real-Time Anisotropic Diffusion using Space-Variant Vision

Many computer and robot vision applications require multi-scale image analysis. Classically, this has been accomplished through the use of a linear scale-space, which is constructed by convolution of visual input with Gaussian kernels of varying size (scale). This has been shown to be equivalent to the solution of a linear diffusion equation on an infinite domain, as the Gaussian is the Green's function of such a system (Koenderink, 1984). Recently, much work has been focused on the use of a variable conductance function resulting in anisotropic diffusion described by a nonlinear partial differential equation (PDF). The use of anisotropic diffusion with a conductance coefficient which is a decreasing function of the gradient magnitude has been shown to enhance edges, while decreasing some types of noise (Perona and Malik, 1987). Unfortunately, the solution of the anisotropic diffusion equation requires the numerical integration of a nonlinear PDF which is a costly process when carried out on a fixed mesh such as a typical image. In this paper we show that the complex log transformation, variants of which are universally used in mammalian retino-cortical systems, allows the nonlinear diffusion equation to be integrated at exponentially enhanced rates due to the non-uniform mesh spacing inherent in the log domain. The enhanced integration rates, coupled with the intrinsic compression of the complex log transformation, yields a seed increase of between two and three orders of magnitude, providing a means of performing real-time image enhancement using anisotropic diffusion.Office of Naval Research (N00014-95-I-0409

The Effect of High Dose Total Body Irradiation on ACTH, Corticosterone, and Catecholamines in the Rat

Total body irradiation (TBI) or partial body irradiation is a distinct risk of accidental, wartime, or terrorist events. Total body irradiation is also used as conditioning therapy before hematopoietic stem cell transplantation. This therapy can result in injury to multiple tissues and might result in death as a result of multiorgan failure. The hypothalamic–pituitary–adrenal (HPA) axis could play a causative role in those injuries, in addition to being activated under conditions of stress. In a rat model of TBI, we have established that radiation nephropathy is a significant lethal complication, which is caused by hypertension and uremia. The current study assessed HPA axis function in rats undergoing TBI. Using a head-shielded model of TBI, we found an enhanced response to corticotropin-releasing hormone (CRH) in vitro in pituitaries from irradiated compared with nonirradiated rats at both 8 and 70 days after 10-Gy single fraction TBI. At 70, but not 8 days, plasma adrenocorticotrophic hormone (ACTH) and corticosterone levels were increased significantly in irradiated compared with nonirradiated rats. Plasma aldosterone was not affected by TBI at either time point, whereas plasma renin activity was decreased in irradiated rats at 8 days. Basal and stimulated adrenal steroid synthesis in vitro was not affected by TBI. In addition, plasma epinephrine was decreased at 70 days after TBI. The hypothalamic expression of CRH messenger RNA (mRNA) and hippocampal expression of glucocorticoid receptor mRNA were unchanged by irradiation. We conclude that the hypertension of radiation nephropathy is not aldosterone or catecholamine-dependent but that there is an abscopal activation of the HPA axis after 10 Gy TBI. This activation was attributable at least partially to enhanced pituitary ACTH production