Research Report 2004–2005

The National Health and Medical Research Council Clinical Trials Centre has the purpose of improving outcomes in health through clinical trials research. It was established by the National Health and Medical Research Council in 1988 as a research centre at the University of Sydney. The CTC provides the knowledge and infrastructure to ensure the quality, timely completion and reporting of clinical trials. It has vast expertise in the design, conduct and analysis of randomised controlled trials, particularly in cancer and cardiovascular disease. Over 100 staff have specialised skills, taking in clinical trials design, biostatistics, database design, randomisation and drug distribution, outcome assessment, quality assurance, and regulatory and ethical issues. In the past 16 years, the CTC has participated in more than 50 investigatorinitiated, collaborative-group clinical trials and coordinated some of the largest randomised trials initiated by Australian investigators (LIPID and FIELD studies, each with over 9000 patients). Over 40 000 patients have been randomised to these trials. All clinical trials undertaken through the CTC are conducted strictly according to guidelines for clinical trials research and conduct, and are audited by sponsors, the CTC itself and regulatory authorities. The CTC has a history of working collaboratively with cooperative groups, clinical trial networks and other organisations, and has played a central role in establishing some of these groups. These activities have been recognised in increased grant funding to enable further collaboration and to increase the number of investigator-initiated trials in Australia. In its research, the CTC has prospered: it has developed strategies for patient recruitment, trial and data management, study coordination, information systems and randomisation in an environment of academic excellence. In addition to trials management, the CTC is a leader in biostatistical methodology and analysis and in systematic review of health evidence. The integrated expertise of the CTC staff is turned to good use in frequent educational activities in Australia and elsewhere. This report covers the CTC’s achievements for the biennium, 2004–2005

Breaking bounds : Alice Profé, radical and emancipationist

La vie et l'oeuvre d'Alice Profé (1887-1946). Son combat pour l'égalité des sexes en Allemagne. Son activisme en faveur de la gymnastique féminine, de la culture physique et de la pratique sportive des femmes (promotion de l'aviron 'stylistique'), de la participation des femmes aux Jeux olympiques

Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice

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Proteintyrosine Phosphatases expressed in mouse epidermal keratinocytes.

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