7 research outputs found
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M.
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S.Y.
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L.
- Berger Duncan J.
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brooks Tony T.
- Broos Alice
- Brown Julianne Rose
- Brown Paul E.
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K.
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L.
- Caller Laura G.
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Charles Ian G.
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K.J.
- Churcher Carol M.
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M.
- Connor Thomas R.
- Connor Thomas R.
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J.
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J.
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L.
- Fleming Vicki M.
- Forrest Leysa M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Frost Lucy R.
- Fuller William
- Gallagher Eileen
- Gallagher Michael D.
- Garcia-Casado Maria V.
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Gilroy Rachel A.J.
- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C.
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F.
- Haldenby Sam T.
- Hale Antony D.
- Hall Grant
- Halstead Fenella
- Hamilton William L.
- Haque Tanzina
- Harper Katherine L.
- Harris Kathryn Ann
- Harrison Ewan M.
- Harrison Ian
- Harrison James W.
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Holden Matthew T.G.
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J.
- Howe Robin
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D.
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A.
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu S.
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R.
- Jesudason Natasha
- Jesudason Natasha G.
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Khokhar Fahad A.
- Kidd Stephen
- Kingsley Robert A.
- Kitchen Christine
- Knight Bridget A.
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack C.D.
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Li Kathy
- Li Kathy K.
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J.
- Loman Nicholas J.
- Loose Matthew W.
- Loveson Katie F.
- Lowe Hannah
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T.
- Masoli Jane A.H.
- Mason Jenifer
- Mather Alison E.
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McCrone John T.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J.
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W.
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F.
- Nascimento Fabricia F.
- Naydenova Plamena
- Neaverson Alexandra S.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M.
- Nichols Jenna
- Niebel Marc O.
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J.
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N.
- Pandey Sarojini
- Park Naomi
- Parker Matthew D.
- Parmar Surendra
- Parr Yasmin A.
- Parsons Paul J.
- Partridge David G.
- Pascall David J.
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan A.I.
- Peacock Sharon J.
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C.
- Rey Sara
- Rey Sara M.
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rogers Hazel A.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M.
- Sang Fei
- Scarlett Garry P.
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K.
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N.
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G.
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Simpson David A.
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Christen
- Smith Colin P.
- Smith Darren
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J.
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben E.W.
- Taylor Graham P.
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P.
- Temperton Ben
- Templeton Kate E.
- Thompson Thomas
- Thomson Emma C.
- Thomson Emma C.
- Thomson Nicholas M.
- Thornton Alicia
- Thurston Scott
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Tutill Helena J.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vamos Edith E.
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B.
- Volz Erik
- Volz Erik M.
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A.
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Willingham Iona
- Wilson Harry D.
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A.
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Elsevier
- Publication date
- 07/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
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- Publication venue
- Publication date
- 01/12/2020
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- Author
- Publication venue
- PeerJ
- Publication date
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- Field of study
The eastern oyster, Crassostrea virginica, is divided into four populations along the western North Atlantic, however, the only published mitochondrial genome sequence was assembled using one individual in Delaware. This study aimed to 1) assemble C. virginica mitochondrial genomes from Texas with pooled restriction-site-associated DNA sequence (ezRAD), 2) evaluate the validity of the mitochondrial genome assemblies including comparison with Sanger sequencing data, and 3) evaluate genetic differentiation both between the Delaware and Texas genomes, as well as among three bays in Texas. The pooled-genome-assembled-genomes (PAGs) from Texas exhibited several characteristics indicating that they were valid, including elevated nucleotide diversity in non-coding and the third position of codons, placement as the sister haplotype of the genome from Delaware in a phylogenetic reconstruction of Crassostrea mitochondrial genomes, and a lack of genetic structure in the ND4 gene among the three Texas bays as was found with Sanger amplicons in samples from the same bays several years prior. In the comparison between the Delaware and Texas genome, 27 of 38 coding regions exhibited variability between the two populations, which were differentiated by 273 mutations, versus 1-13 mutations among the Texas samples. Using the full PAGs, there was no additional evidence for population structure among the three Texas bays. While population genetics is rapidly moving towards larger high-density datasets, studies of mitochondrial DNA (and genomes) can be particularly useful for comparing historic data prior to the modern era of genomics. As such, being able to reliably compile mitochondrial genomes from genomic data can improve the ability to compare results across studies
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- Alleen Pace Nilsen
- Amy Pattee
- Angela McRobbie
- Anne Scott MacLeod
- Barbara Dafoe Whitehead
- Barbara Martinec
- Beth Younger
- Brian W Sturm
- Bryan Gillis
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- Christine Seifert
- Cynthia Miller Coffel
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- Deirdre M Kelly
- Diane Emge
- Frank F Furstenberg Jr
- Frank F Furstenberg Jr
- Gail S Murray
- Helen Wilson
- Henry Gregor Felsen
- Hilary S Crew
- James T Henke
- Jeffrey S Kaplan
- Jerry D Marx
- Jo Knowles
- Joseph B Tamney
- Joy B Davis
- Judith S Musick
- Karen Coats
- Katrina Wegar
- Keith W Kraus
- Kelly Jerome
- Kimberley Reynolds
- Kristen Nichols
- Linda K Christian-Smith
- Louisa-Jane Smith
- Lydia Kokkola
- Lydia Kokkola
- Lynn S Cockett
- Mark A Lewis
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- Melanie D Koss
- Michael Carr
- Michael J Meyer
- Mike Cadden
- Nancy Lesko
- Norma Klein
- Patricia L East
- Ramona Caponegro
- Sara K Day
- Sarah A Leavitt
- Stanley Hoffman
- Stephanie Coontz
- Susan Moore
- Susan Ritchie
- Tracy A Weitz
- Victor Watson
- Publication venue
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- Publication date
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- Author
- Aarsman K
- Abel Sylvie
- Abeler-Dörner Lucie
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- Abgueguen Pierre
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- Ackens R P
- Adam Axel
- Adams A
- Agher Nouara
- Ahmad S
- Ainsworth J
- Aissi Emmanuelle
- Ajana Faïza
- Al Moujahid A
- Alagna Laura
- Albers M
- Albert Jan
- Alberto A
- Alcaraz Isabelle
- Allavena Clotilde
- Allegre Thierry
- Allen S
- Allienne Christophe
- Alvarez Muriel
- Alvarez-Huve Sandrine
- Amirat Naouel
- Ammerlaan H S M
- Anderson J
- Andrady U
- Andre Marie
- Ang C W
- Antoniotti Odile
- Antonucci S
- Aquilina Christian
- Arastéh Keikawus
- Arbter Peter
- Arends J E
- Arumainayyagam J
- Arvieux Cédric
- Aslan Alexandre
- Assi Assi
- Atoui Nadine
- Aubert V
- Audebert Franz
- Aumaitre Hugues
- Autar R S
- Avettand Fenoel Véronique
- Baas S
- Babiker Abdel
- Back N K T
- Baclet Véronique
- Baillat Vincent
- Bakker M
- Bakker Margreet
- Bakker Y
- Balausine Stéphanie
- Balsarin Florence
- Bannert Norbert
- Bannert Norbert
- Bansaal D
- Bantsimba Jonas
- Barbe Frédérique
- Barbuat Claudine
- Barin Francis
- Barth R E
- Bassant N
- Bastides Frédéric
- Batala Anne-Sophie
- Batard Marie-Laure
- Batisse Dominique
- Battegay M
- Baudry Thomas
- Baumgarten Axel
- Bax H I
- Bazin Christine
- Beck Charles
- Beck-Wirth Geneviève
- Belan Alix Greder
- Belarbi Linda
- Bellenger Katharine
- Ben Abdallah Saadia
- Benomar Meryem
- Berger Jean-Luc
- Bergsma D
- Berkhout B
- Berkhout Ben
- Bermon N
- Bernard Louis
- Bernard Noëlle
- Bernard-Henry Claudine
- Bernasconi E
- Berrebi Valérie
- Berrevoets M A H
- Berthe Huguette
- Berzow Dirk
- Besnier Michel
- Bevan M
- Bevan Margaret-Ann
- Bezemer D O
- Bezemer Daniela
- Bezemer M
- Biekre Raphael
- Bieniek Bernhard
- Bierman W F W
- Biezunski Noemie
- Billaud Eric
- Blaauw H
- Blackman H
- Blackman Helen
- Blanc Arnaud
- Blanquart François
- Bloch Martine
- Blok W L
- Bodard Loïc
- Bogner Johannes
- Bollens Diane
- Bolliot Claudine
- Bomers M
- Bonmarchand Manuela
- Bonnet Bénédicte
- Bonnet Fabrice
- Bonsall David
- Bont L J
- Boonstra A
- Bor P C J
- Bornarel Dominique
- Bottero Julie
- Bouchaud Olivier
- Boucher C A B
- Bouchez Sabelline
- Boue François
- Bourgeois Christine
- Boussard Jean-Luc
- Boutoille David
- Bouwhuis J W
- Bowman C
- Boyd A C
- Branger J
- Braun D L
- Brewer C
- Bridgwood A
- Brinkman K
- Brochier Corinne
- Brockmeyer Norbert
- Brokking W
- Brosseau Delphine
- Brouwer A E
- Brouwer A E
- Browing M
- Brunel-Dalmas Florence
- Brunet Cecile
- Bruns A H W
- Brétin N
- Bucher H C
- Buisson Marielle
- Buisson Martin
- Buiting A
- Buiting A G M
- Burger D
- Burgers K
- Burton-Jeangros C
- Bushby S
- Byrne P
- Böni J
- Cabie André
- Cabras Ornella
- Caby Fabienne
- Cahitte Isabelle
- Calderwood J
- Calin Ruxandra
- Calmy A
- Caltado Sabrina
- Campa Pauline
- Campbell L
- Cardon Fanny
- Care C
- Care Christine
- Carganico Andreas
- Carrick G
- Castel Philippe
- Cavassini M
- Cazanave Charles
- Cazenave Benoit
- Cents-Bosma A S
- Cerland Christophe
- Chabrol Amélie
- Chaigne de Lalande Severin
- Chaix Fabrice
- Chaix Marie-Laure
- Chambrin Véronique
- Champagne Hélène
- Chandramani S
- Chantalat Christelle
- Chapplain Jean-Marc
- Chardon Patricia
- Chas Julie
- Chavanet Pascal
- Cheneau Christine
- Chennebault Jean Marie
- Cheret Antoine
- Chevojon Pierre
- Chiarello Pierre
- Chirouze Catherine
- Christl Andreas
- Claas E C J
- Claassen M
- Clarke Mindy
- Claus Bernd
- Claus Jörg
- Clavel François
- Cloarec Nicolas
- Cohen Stuart J W T
- Colin de Verdiere Nathalie
- Collias Lio
- Connolly L
- Conort Guillaume
- Consigny Paul Henri
- Cordes Christiane
- Cordonnier François
- Cornavin Pauline
- Cornelissen M T E
- Cornelissen Marion
- Coupard Mélissa
- Croisier Delphine
- Cros Agnes
- Cua Eric
- Curlier Elodie
- Currie J
- Cuzin Lise
- Daneluzzi Vincent
- Daniel Corinne
- Dauchy Frédéric
- David L
- Davido Benjamin
- Davids-Veldhuis S
- de Boer C
- de Boer M G J
- De Castro Nathalie
- de Cesare Mariateresa
- de Groot J
- de Groot L
- de Groot-de Jonge H
- de Haan M
- de Jong A
- de Jong-Peltenburg N C
- de Kroon I
- de Kruijf-van de Wiel B A F M
- de la Blanchardiere Arnaud
- de Mendonç A Melo M
- de Munnik E S
- de Regt M
- de Tejada B Martinez
- De Truchis Pierre
- de Vries-Sluijs T E M S
- de Weerd D A
- Dean G
- Debab Yasmine
- Debard Alexa
- Debast S B
- Dehn Günther
- Deiman B
- Delacroix Isabelle
- Delestan Mikael
- Delfraissy Jean François
- Delgado Jeannine
- Delllion Sophie
- Delobel Pierre
- Delpech Valerie
- Delsing C E
- den Hollander J G
- Denes Éric
- Depond Audrey
- Derouineau Jean
- DeSouza C
- Detering-Hübner Barbara
- Devendra S V
- Devidas Alain
- Diab Georges
- Diemer Myriam
- Dinh Aurélien
- Djoechro E
- Dofferhoff A S M
- Dollenmaier G
- Dondia Denis
- Donnelly C
- Donsesco Régine
- Dorama W
- Douma R A
- Drake S
- Drobacheff-Thiebaut Christine
- Ducroix Sophie
- Duffau Pierre
- Duijf-van de Ven C J H M
- Dulucq Marie Josée
- Dumont Cécile
- Dunais Brigitte
- Duong Michel
- Dupke Stephan
- Dupont Matthieu
- Dupont Michel
- Duracinsky Martin
- Durant Jacques
- Durox Hélène
- Dutronc Hervé
- Duvivier Claudine
- Eden Aurélia
- Egger M
- El Berkaoui A
- El Moussaoui R
- Elharrar Brigitte
- Eliazevitch Murielle
- Ellerbroek P M
- Elsenburg L J M
- Elzi L
- Esnault Jean-Luc
- Essat Asma
- Esser Stefan
- Estreich S
- Evans M
- Faber S
- Fabre Isabelle
- Fairbrother Keith
- Fairley I
- Faucher Jean-François
- Faucher Olivia
- Faulkner S
- Faulkner Sue
- Faure Isabelle
- Faville R
- Faville Rebecca
- Fehr J
- Fellay J
- Fellay Jacques
- Fenske Stefan
- Feret Philippe
- Ferret Samuel
- Ferretti Luca
- Ferreyra Milagros
- Fialaire Pascale
- Fidler S
- Fidler S
- Fily Fabien
- Fischer Hugues
- Fischer Klaus
- Fischer Patricia
- Fitzgerald M
- Flegg P
- Foltzer Adeline
- Fonquernie Laurent
- Fox J
- Fox Julie
- Fraaij P L A
- Fraser Christophe
- Fraser P
- Freiwald Matthias
- Frietsch Bernhard
- Froguel Eric
- Fröschl Monika
- Furrer H
- Fux C A
- Gall Astrid
- Galle Peter
- Garipuy Daniel
- Garrait Valérie
- Gatey Caroline
- Gaud Catherine
- Gazaigne Sandrine
- Geelen S P M
- Geerders G F
- Geerlings S E
- Geffray Loïk
- Gehring Peter
- Geilings J
- Gelinck L B S
- Gellen-Dautremer Justine
- Genet Claire
- Genet Philippe
- Gerard Laurence
- Gerbe Juliette
- Ghosn Jade
- Gibert Sylvie
- Gilleran G
- Gilquin Jacques
- Gilson R
- Gilson R
- Girard Jean-Jacques
- Girard Pierre-Marie
- Gisolf E H
- Glaunsinger Tobias
- Godin Collet Claire
- Godinot Mathieu
- Gohier Sandrine
- Goldberg David
- Golubchik Tanya
- Gomez M
- Gompels M
- Goorhuis A
- Goorney B
- Gorgievski M
- Goujard Cécile
- Gourdon Florence
- Goussef Marie
- Grabowski M Kate
- Graefe Katrin
- Green P
- Green Pippa
- Green S
- Greenhough D
- Griffioen-van Santen B M G
- Grintjes-Huisman K J T
- Groeneveld P H P
- Grossi Olivier
- Groters M
- Guillevin Loïc
- Guimard Thomas
- Gunsenheimer-Bartmeyer Barbara
- Gunsenheimer-Bartmeyer Barbara
- Güler Cengiz
- Günthard H
- Günthard Huldrych F
- Hadacek Blanka
- Haerry D
- Haffner-Mauvais Cécile
- Hage de Looff L
- Halaby T
- Hall Matthew
- Hall Nolwenn
- Halna Jean-Michel
- Hansen Stefan
- Harding J
- Haret Sophie
- Harindra V
- Hasse B
- Hassing R J
- Havenith T R A
- Hawkins D
- Hawkins David
- Hazenberg A
- Heikens E
- Heitmuller M
- Henriet S S V
- Herman S
- Herman Sandra
- Herpers B L
- Hertling Sandra
- Hessamfar Mojgan
- Higgs C
- Hillebregt M
- Hillenbrand Heribert
- Hintsche Bettina
- Hiraux Emmanuel
- Hirsch H H
- Hittinger Gilles
- Hoen Bruno
- Hoepelman A I M
- Hoffmann M
- Holtsema H
- Honore Patricia
- Hoogerwerf J
- Hoogewerf M
- Houlbert Dominique
- Hovius J W
- Howard L
- Hower Martin
- Hue Hervé
- Huleux Thomas
- Hustache Mathieu Mathieu
- Häussinger Dieter
- Hösli I
- Ingiliz Patrick
- Jacomet Christine
- Jacquet Jean Marc
- Jansen E R
- Jansen R
- Jansz A R
- Jayle Didier
- Jeantils Vincent
- Jebakumar S P R
- Jennings L
- Jerbi Saadia
- Jessen Arne
- Jessen Heiko
- Jeunet Noëlle
- Johnson Anne
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- Johnson Margaret
- Jolink H
- Jonges M
- Joulie Aline
- Jung Corinne
- Jurriaans S
- Jä Gel-Guedes Eva
- Jäger Hans
- Kahlert C
- Kaiser L
- Kampschreur L M
- Kansau Imad
- Karmochine Marina
- Katlama Christine
- Keelan-Phaf S
- Keiser O
- Kellam Paul
- Kellock D
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- Kern Peter
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- Kirstetter Myriam
- Kivelä Pia
- Klausen Gerd
- Kleene M J
- Kleinnijenhuis J
- Klimkait T
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- Knapen M
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- Koffi Joseph
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- Koopmans M P G
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- Kousignan Pascale
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- Kowalczyk Jakub
- Kraan S
- Kreckel Peter
- Kreft Burkhard
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- Ktorza Nadine
- Kuijpers T W
- Kuldanek K
- Kuldanek Kristin
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- Lacey H
- Lacoste Denis
- Laeyendecker Oliver
- Lafaurie Matthieu
- Lafeuillade Alain
- Lafon Erik
- Lagarrigue Myriam
- Lagneau Jean-Luc
- Lamaury Isabelle
- Lambregts M M C
- Lambry Véronique
- Lammers A J J
- Langebeek N
- Lanternier Fanny
- Lascaux Anne Sophie
- Lascoux-Combe Caroline
- Lauenroth-Mai Elke
- Launay Odile
- Lauw F N
- Lawlor V
- Le Puil Séverine
- Lean C
- Leantez-Nainville Sophie
- Lechiche Catherine
- Lecuroux Camille
- Ledergerber B
- Lefebvre Benedicte
- Lefeuvre Céline
- Lefort Agnès
- Lelievre Jean Daniel
- Lelivelt K J
- Lemercier Yvon
- Lemoing Vincent
- Lempkes B
- Lenagat Sophie
- Leplatois Anne
- Leport Catherine
- Lepretre Annie
- Lerolle Nathalie
- Leroy Helene
- Lettinga K D
- Leureillard Didier
- Levy Yves
- Leyten E M S
- Livrozet Jean-Michel
- Loay D
- Lodewijk C
- Loeffen Y G T
- Lorenzen Thore
- Loulergue Pierre
- Louni Françoise
- Lowe S H
- Lucas E
- Luycx Odile
- Lyavanc Thomas
- Lynn W
- Machado Moise
- MacIntyre-Cockett George
- Magdy A
- Mahy Sophie
- Maignan Aline
- Majerholc Catherine
- Makhloufi Djamila
- Makinson Alain
- Malet Martine
- Malvy Denis
- Manceron Véronique
- Marigot Dhiba
- Markus Rudolf
- Marneef M
- Marquardt Ties
- Martell Cédric
- Martha Benoît
- Martin Anne
- Martin Isabelle Poizot
- Martinetti G
- Martinot Martin
- Marzolini C
- Masse Virginie
- Massip Patrice
- Mauboussin Jean-Marc
- May Thierry
- Mayr Christoph
- Mazhude C
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- McKernan S
- McKernan Sinead
- McLean K
- McLean Ken
- Meaden J
- Medus Marie
- Meijering R
- Meixenberger Karolin
- Melville R
- Mercie Patrick
- Merle Corinne
- Merlet Audrey
- Merrien Dominique
- Mette R
- Metzner K
- Meybeck Agnès
- Meyer Andreas
- Meyer Laurence
- Meyer Laurence
- Mguni S
- Miailhes Patrick
- Michel Catherine
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- Middel A
- Minozzi Catherine
- Minton J
- Molina Jean-Michel
- Moll Arend
- Mollema F
- Moreau Philippe
- Morineau-Le Houssine Pascale
- Morlat Philippe
- Morris S
- Mortier Emmanuel
- Mouton-Rioux Virginie
- Moyes A
- Mudrikova T
- Mulder-Seeleman E
- Mullaney S
- Mullaney Scott
- Munier Anne-Lise
- Munjishvili L
- Murck J L
- Murphy C
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- Muthern Lisa
- Müller Marcus
- Müller N
- Nadal D
- Nait-Ighil Lella
- Naqvi Alissa
- Nastouli Eleni
- Natarajan U
- Nau Pascale
- Nauta N
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- Neuville Ségolène
- Niault Mathilde
- Nicca D
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- Obadia Martine
- Ong E
- Ong Swee Hoe
- Oosterheert J J
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- Ouissa Rachida
- Paccalin François
- Pachart Anne
- Pailhes Sylvie
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- Paling F
- Pantaleo G
- Parcelier François
- Parrinello Maguy
- Partisani Maria
- Patey Olivier
- Patra-Delo Solène
- Pavie Juliette
- Paz Pauline Caraux
- Peacock K
- Peeck B
- Pellegrin Jean-Luc
- Penot Pauline
- Peretti Delphine
- Perre Philippe
- Perrone Véronique
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- Pertusa Marie-Carmen
- Peters E J G
- Petrov-Sanchez Ventzislava
- Peyramond Dominique
- Philip Gisèle
- Phillips Andrew
- Phung Bao
- Pialoux Gilles
- Picard Odile
- Pichancourt Gilles
- Pichon François
- Pierre Isabelle
- Pierre-Francois Sandrine
- Pietri Marie-Pierre
- Pijnappel F J J
- Pinet Pauline
- Pintado Claire
- Pinto Adriana
- Piroth Lionel
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- Plettenberg Andreas
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- Porte Lydie
- Porter Kholoud
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- Posthouwer D
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- Prevoteau du Clary François
- Priester Michèle
- Prins J M
- Pritchard J
- Pronk M J H
- Proust Aurélie
- Psomas Christina
- Quertainmont Yann
- Quinsat Denis
- Rabier Valérie
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- Rahamat-Langendoen J
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- Rajamanoharan S
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- Rami Agathe
- Rangom Camille
- Rauch A
- Rausch Michael
- Ravaux Isabelle
- Raymond Isabelle
- Receveur Marie-Catherine
- Ree C
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- Rehaiem Sami
- Reimann Evelyne
- Reiss P
- Reiss Peter
- Reliquet Véronique
- Renckens R
- Reuter Stefan
- Reuwer A
- Revest Matthieu
- Rey David
- Reynes Jacques
- Ribeiro Emmanuel
- Ricaud Carole
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- Ristola Matti
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- Rohan Jennifer
- Rokx C
- Rooijakkers E O W
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- Rosenthal Eric
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- Ruiter-Pronk D
- Russell H
- Rutkens T
- Saada Mathieu
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- Salmon Dominique
- Salzberger Bernd
- Sauser Fabienne
- Sautron Carmele
- Schadd E M
- Schaffert Andreas
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- Schlote Frank
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- Schneider Luminita
- Schnörr P
- Schoorl M
- Schouten W E M
- Schranz Dietmar
- Schreiber Maria
- Schubert Franz
- Schulbin Hubert
- Schuler Christoph
- Schurink C A M
- Schuurman R
- Schölmerich Jürgen
- Schölvinck E H
- Schöni-Affolter F
- Schürmann Dirk
- Segeral Olivier
- Seghezzi Jean-Christophe
- Seng Rémonie
- Shoai-Tehrani Michka
- Short L
- Sigaloff K C E
- Silbermann Benjamin
- Siminoni A
- Simon Anne
- Simon Philippe
- Simonet Véronique
- Simonpoli Anne-Marie
- Singh G
- Sinnige J C
- Sivakumar K
- Slama Laurence
- Slobbe L
- Smalhout S Y
- Smit C
- Smit J V
- Snart B
- Sobel Alain
- Soetekouw R
- Sotto Albert
- Souak Safia
- Souala Faouzi
- Speck R
- Speer Miriam
- Speidel Andrea
- Spinner Christoph
- Spornraft-Ragaller Petra
- Stalenhoef J E
- Stanley B
- Steeman-Bouma R
- Stegeman A
- Stellbrink Hans-Jürgen
- Stelma F F
- Stemp C
- Stienstra Y
- Stoehr Albrecht
- Strik-Albers R
- Strohbach Frank
- Struik-Kalkman D
- Stöckle M
- Stündel Manfred
- Suaud Isabelle
- Sukthankar A
- Summerfield H
- Swanink C M A
- Sweeney J
- Tabet Magda
- Tahi Tassadit
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- Tassi Sylvie
- Tattevin Pierre
- Taulera Olivier
- Tayal S
- Taylor B
- Teague A
- Tearno C
- Tempesta Serge
- Ter Beest G
- Ter Hofstede H J M
- Theresine Nadine
- Thoirain Valérie
- Thorpe S
- Thu-Huyn Nugyen
- Tiemessen R
- Timsit Julie
- Tjhie J
- Toomer S
- Toonen A J M
- Touam Fatima
- Tourneur Muriel
- Tramoni Christine
- Tredup Jürgen
- Trein Andreas
- Trepo Christian
- Trkola A
- Truvedi M
- Tubiana Roland
- Tuijn E
- Turpault Isabelle
- Ulmer Albrecht
- Uludag Agnès
- Valantin Marc Antoine
- Valette Michel
- Valin Nadia
- Vallois Dorothée
- van Aerde K
- van Agtmael M A
- van Beek J E A
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- van Berkel M
- van Broekhuizen M C
- van Burgel N D
- van Crevel R
- van de Sande L
- van de Wetering D
- van den Akker M
- van den Berge M
- van den Berk G E L
- van den Bersselaar D N J
- van der Bliek G L
- van der Burg-van de Plas M
- van der Hut G
- van der Knaap L C
- van der Meché I B
- van der Meer I
- van der Meulen P A
- van der Plas A
- van der Poll T
- van der Prijt L M M
- van der Reijden W A
- van der Reijden W A
- van der Swaluw J
- van der Valk M
- van der Ven B
- van der Ven B
- van der Vliet S
- van Duinen M
- van Eden J
- van Eeden A
- van Erve R
- Van Frankenhuijsen Maartje
- van Gorp E C M
- van Hes A M H
- van Holten N
- van Houdt R
- van Hulzen A G W
- van Ijperen J M
- van Kampen J J A
- van Kasteren M E E
- van Leer-Buter C C
- van Lelyveld S F L
- van Loo I H M
- van Niekerk T
- van Nieuwkoop C
- van Nood E
- van Rooijen C S A M
- van Rossum A M C
- van Sighem A I
- van Sighem Ard
- van Truijen-Oud F A
- van Twillert G
- van Vonderen M G A
- van Vugt M
- van Welzen B J
- van Wijk M
- van Wolfswinkel M E
- van Zonneveld L M
- Vandenhende Marie-Anne
- Vareil Marc-Olivier
- Veenemans J
- Veenenberg L
- Veenendaal D
- Veenstra J
- Verbon A
- Verdon Renaud
- Verduyn-Lunel F
- Verhage A R
- Verhagen D W M
- Vermont C L
- Vernazza P
- Viallard Jean-François
- Viard Jean-Paul
- Viget Nathalie
- Visser E
- Visser K M
- Vittecoq Daniel
- Voigt R
- Vriesde M
- Vrouenraets S M E
- Wagenvoort G H J
- Waldner Anne
- Wandolo Emily
- Wartel Guillaume
- Waters A
- Weber R
- Wegdam M C A
- Weijenberg-Maes B
- Weijsenfeld A M
- Weinberck Pierre
- Weiss Laurence
- Weitner Lutwin
- Wemmert Charlotte
- Wensing A M J
- Wesselmann Hans
- Wessels E
- White C
- White D
- Wicke Thomas
- Wiemer Dorothea
- Wiersinga W J
- Wijnands S
- Wildenbeest G S
- Wilding H
- Wilkins E
- Williams O
- Winter A
- Wintermans B
- Wirth Gaétane
- Wit F W M N
- Wither J
- Witte E C
- Wolfs T F W
- Wolthers K C
- Woodward R
- Woudstra T
- Wouthuyzen-Bakker M
- Wttewaal E
- Wymant Chris
- Yazdanpanah Yazdan
- Yerly S
- Young Carmel
- Young F
- Young S
- Youssef Elaney
- Zaaijer H L
- Zadeh Mahsa Mohseni
- Zaheri S
- Zak Dit Zbar Olivier
- Zeng Ai-Feng
- Zhao Lele
- Zucchetti Antonella
- Zucman David
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 04/02/2022
- Field of study
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant