2 research outputs found
Application and future perspective of trichloroacetic acid in the treatment of cervical intraepithelial neoplasia after cold knife conization
Background: Factors that contribute to
development of cervical intraepithelial neoplasia
are: age older than 55, and infection with
persistent, high risk Human papillomavirus
(HPV). If the HPV remains in an episomal
nonintegrated state, it results with low grade
lesion and if virus becomes integrated into the
human genome, high grade lesions and cancer
may develop. Low grade lesion is cervical
intraepithelial neoplasia and it refers to mildly
atypical cellular changes in the lower third of the
epithelium. High grade cervical lesions are
cervical intraepithelial neoplasia II and III. CIN
II refers to moderately atypical cellular changes
confined at the basal two thirds of the epithelium
and CIN III refers to severely atypical cellular changes encompassing greater than two thirds of
the epithelial thickness. Cold knife conization
usually is the treatment of choice for high grade
cervical lesions.
Case report: We present a case of new creative
treatment with 85% trichloroacetic acid, of low
grade cervical intraepithelial neoplasia, which
was a residual cervical lesion after a cold knife
conization preformed for high grade cervical
intraepithelial neoplasia grade treatment.
Conclusion: Single topical use of 85%
trichloroacetic acid is an effective treatment for
residual persistent cervical intraepithelial
neoplasia of low grade, after cold knife
conization and provides long term remission and
satisfying Human papillomavirus clearance. Thus 85% trichloroacetic acid treatment can directly
diminish morbidity and mortality of Human
papilloma virus related to precancerous cervical
lesions and cervical carcinoma
Diagnostic challenge and conservative msnsgement of cervical pregnancy with uterus presevation
Cervical pregnancy is a rare form of ectopic pregnancy in which the embryo implants in the
lining of the endocervical canal. Clinical criteria and ultrasound features, supplemented by rapid assay of
serum human chorionic gonadotropin (hCG), make the diagnosis easier and more accurate. Depending on
the time of diagnosis and the patient’s condition, management can be conservative or operative
Case: We present a rare case of cervical pregnancy with all the diagnostic challenges for making
an early diagnosis and choosing the right treatment regimen, which can be life saving for the patients and
can reduce the chance of severe hemorrhage necessitating hysterectomy or blood transfusion
Early diagnosis, appropriate methotrexate regimen and combination of necessary adjuvant
conservative procedures could contribute to successful treatment with preservation of the uterus and future
reproductive ability