THE EXCLUSION OF ILLEGAL HISPANICS IN AGENDA-SETTING: THE IMMIGRATION REFORM AND CONTROL ACT OF 1986

In November of 1986, the Immigration Reform and Control Act, designed primarily to control illegal Hispanic residents was signed into law. The new policy as implemented failed to remove, via legalization, illegal residents residing within the United States. The perspectives of Hispanic organiza- tions and 594 illegal residents were collected and evaluated to ascertain those variables that may have served to negate this public policy. The utilization of a subsequent qualitative and discriminant analysis indicated that the exclusion and/or lack of consideration given the perspectives of policy targeted groups and individuals in agenda setting, adversely affected the efficacy of the policy-making process, and thus, the laws it creates. Copyright 1989 by The Policy Studies Organization.

NONWHITE MINORITY ACCESS TO THE POLITICAL AGENDA IN BRITAIN

The theoretical literature on agenda-setting, largely developed in the United States, is applied to the problem of minority group access to the political agenda on race relations and immigration issues in the United Kingdom. Empirical emphasis is placed on the institutional opportunities and constraints for minority group access on major issues of concern in recent years. Nonwhite access to the political agenda in Britain remains minimal and problematic. The conclusion places these findings into the general literature on agenda setting. Copyright 1989 by The Policy Studies Organization.

Regulation of Focal Adhesion Kinase by a Novel Protein Inhibitor FIP200

Focal adhesion kinase (FAK) is a major mediator of integrin signaling pathways. The mechanisms of regulation of FAK activity and its associated cellular functions are not very well understood. Here, we present data suggesting that a novel protein FIP200 functions as an inhibitor for FAK. We show the association of endogenous FIP200 with FAK, which is decreased upon integrin-mediated cell adhesion concomitant with FAK activation. In vitro- and in vivo-binding studies indicate that FIP200 interacts with FAK through multiple domains directly. FIP200 bound to the kinase domain of FAK inhibited its kinase activity in vitro and its autophosphorylation in vivo. Overexpression of FIP200 or its segments inhibited cell spreading, cell migration, and cell cycle progression, which correlated with their inhibition of FAK activity in vivo. The inhibition of these cellular functions by FIP200 could be rescued by coexpression of FAK. Last, we show that disruption of the functional interaction between endogenous FIP200 with FAK leads to increased FAK phosphorylation and partial restoration of cell cycle progression in cells plated on poly-l-lysine, providing further support for FIP200 as a negative regulator of FAK. Together, these results identify FIP200 as a novel protein inhibitor for FAK

Observation in the MINOS far detector of the shadowing of cosmic rays by the sun and moon

The shadowing of cosmic ray primaries by the moon and sun was observed by the MINOS far detector at a depth of 2070 mwe using 83.54 million cosmic ray muons accumulated over 1857.91 live-days. The shadow of the moon was detected at the 5.6 sigma level and the shadow of the sun at the 3.8 sigma level using a log-likelihood search in celestial coordinates. The moon shadow was used to quantify the absolute astrophysical pointing of the detector to be 0.17 +/- 0.12 degrees. Hints of interplanetary magnetic field effects were observed in both the sun and moon shadow. Published by Elsevier B.V

The NuMI neutrino beam

This paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important design details of individual components are described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed. © 2015 Elsevier B.V. All rights reserved

Observation in the MINOS far detector of the shadowing of cosmic rays by the sun and moon

The shadowing of cosmic ray primaries by the moon and sun was observed by the MINOS far detector at a depth of 2070 mwe using 83.54 million cosmic ray muons accumulated over 1857.91 live-days. The shadow of the moon was detected at the 5.6 σ level and the shadow of the sun at the 3.8 σ level using a log-likelihood search in celestial coordinates. The moon shadow was used to quantify the absolute astrophysical pointing of the detector to be 0.17 ± 0.12°. Hints of interplanetary magnetic field effects were observed in both the sun and moon shadow. © 2010 Elsevier B.V. All rights reserved

Search for lorentz invariance and CPT violation with the MINOS Far detector

We searched for a sidereal modulation in the MINOS far detector neutrino rate. Such a signal would be a consequence of Lorentz and CPT violation as described by the standard-model extension framework. It also would be the first detection of a perturbative effect to conventional neutrino mass oscillations. We found no evidence for this sidereal signature, and the upper limits placed on the magnitudes of the Lorentz and CPT violating coefficients describing the theory are an improvement by factors of 20-510 over the current best limits found by using the MINOS near detector. © 2010 The American Physical Society

Observation in the MINOS far detector of the shadowing of cosmic rays by the sun and moon

The shadowing of cosmic ray primaries by the moon and sun was observed by the MINOS far detector at a depth of 2070 mwe using 83.54 million cosmic ray muons accumulated over 1857.91 live-days. The shadow of the moon was detected at the 5.6 σ level and the shadow of the sun at the 3.8 σ level using a log-likelihood search in celestial coordinates. The moon shadow was used to quantify the absolute astrophysical pointing of the detector to be 0.17 ± 0.12°. Hints of interplanetary magnetic field effects were observed in both the sun and moon shadow