Prevalência de fraturas por acidentes automobilisticos em um hospital público do Piauí/ Prevalence of fractures by automobilistic accidents in a public hospital in Piauí

INTRODUÇÃO: Com a evolução da indústria e consequente aumento do número de veículos, somado a práticas inadequadas e vigilância insuficiente, os acidentes de trânsito automobilísticos passaram a ser causa relevante de traumatismos na população mundial. OBJETIVO: Avaliar a prevalência de fraturas em pacientes vítimas de acidentes automobilísticos de um hospital público do Piauí. MÉTODO: Estudo retrospectivo, feito através de dados de 449 prontuários, de janeiro de 2018 a fevereiro de 2020. Contará com particularidades como: raça, sexo, idade, parte do corpo acometida, lado acometido, classe de fratura, mecanismo de lesão e escolaridade. RESULTADOS: Ficou evidente o predomínio de homens (77,8 %), com idade média de 32 anos. Foi observado maior prevalência de lesões em membros superiores, advindas por quedas de motocicletas (67,93 %), no asfalto urbano e durante o trabalho. Os tipos de fraturas mais encontradas foram as tranversas (2018), cominutiva (2019) e no ano de 2020 uma variação de transversas e cominutivas. CONCLUSÃO: Conclui-se com altos valores de fraturas relacionados aos acidentes de trânsito, podendo ter relação com a falta de conscientização da população. Com isso, se faz necessário o aumento de medidas preventivas para o trânsito

Perfil baropodométrico em crianças atendidas em uma clínica de fisioterapia / Baropodometric profile in children attended in a physiotherapy clinic

A baropodometria é um equipamento utilizado para avaliar pressões plantares, centro de gravidade e tipologia podal. Há escassez na literatura de artigos que falem sobre a utilização deste exame na avaliação da pisada de crianças. O objetivo deste estudo foi avaliar o perfil de pisada de crianças atendidas em uma clínica particular de Teresina – PI. Para isso foi realizado um estudo transversal com abordagem quali-quantitativa de caráter documental de exames baropodométricos cadastrados no banco de dados realizados no período de 2013 a 2018. Observou-se que não houve correlação entre as variáveis, altura, peso, IMC, idade e o pico de pressão plantar máximo. 94% dos exames avaliados apresentaram pé cavo. O estudo evidenciou que não houve uma correlação significativa do pico de pressão plantar com os dados antropométricos (idade, peso, altura, IMC), e maior incidência de pé cavo e centro de gravidade posteriorizado à direita.

The Platonia insignis Mart. as the Promising Brazilian ‘Amazon Gold’: The State-of-the-Art and Prospects

Bacuri (Platonia insignis) is a monotype belonging to the Clusiaceae family. Of Amazonian origin, it is highly appreciated for fresh consumption, mainly due to its peculiar sensory characteristics. It is also widely used in the food industry, mainly in pulp (endocarp), used in the manufacture of beverages, jellies, and ice cream. Although the use of pulp is well established in the food sector, recently, research has turned attention to the use of other parts of the fruit and plant, especially in the therapeutics, cosmetics, and fuel sectors. Its bioactive components have been investigated for having important antioxidant, anti-inflammatory, immunomodulatory, hypotensive, cardioprotective, antiepileptic, antileishmanial, and antifungal activities, among others, mainly attributed to the presence of compounds such as xanthones, terpenes, phenolics, and fatty acids. Thus, this study aimed to gather data on the species Platonia insignis Mart. through an integrative review of the agronomic, nutritional, physical–chemical characteristics and a technological prospection about its applications. The study showed that in the last ten years there has been a significant increase in the number of patents deposited, with the prospect that with the advancement of studies on their properties, results for application in the most diverse areas will prove increasingly viable and promising

Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review

Monoterpenes are secondary metabolites of plants belonging to the terpenoid class of natural products. They are the most abundant components of essential oils that are generally considered to have various pharmacological properties. These compounds are reported to have antidiabetic effects in recent years. Due to nature’s complex biosynthetic machinery, they also exhibit a reasonable degree of structural complexity/diversity for further analysis in structure-activity studies. Therefore, monoterpenes as antidiabetic agents have been investigated by recent in vitro and in vivo studies extensively reported in the scientific literature and claimed by patent documents. The purpose of this survey is to provide a comprehensive and prospective review concerning the potential applications of monoterpenes in the treatment of diabetes. The data for this research were collected through the specialized databases PubMed, Scopus, Web of Science, and ScienceDirect between the years 2014 and 2022, as well as the patent databases EPO, WIPO, and USPTO. The research used 76 articles published in the leading journals in the field. The main effect observed was the antidiabetic activity of monoterpenes. This review showed that monoterpenes can be considered promising agents for prevention and/or treatment of diabetes as well as have a marked pharmaceutical potential for the development of bioproducts for therapeutics applications

Solid Lipid Nanoparticles from <i>Platonia insignis</i> Seeds, a Brazilian Amazon Fruit: Characterization, In Vitro and In Vivo Toxicological and Antioxidant Activities

Solid Lipid Nanoparticles (SLNs) are drug delivery systems with important advantages over conventional nanosystems. Considering previously reported pharmacological and physicochemical properties of Platonia insignis seed butter (BBI), this work aimed at developing, characterizing and performing toxicological and antioxidant studies of SLNs produced from BBI. The GC-MS analysis identified palmitic and oleic acids as the major compounds. Three SLN prototypes were developed through high-shear homogenization followed by ultrasonication. During a 180-day stability evaluation, the formulation SLN/TW-1.5 presented greater stability since pH was around 6.0, as well as a lesser variation of the PdI (Polydispersity Index), particle size and Zeta Potential (ZP), confirmed with Raman Spectroscopy and Atomic Force Microscopy (AFM). The CC50 in macrophages was around 249.4 µg∙mL−1 for BBI, whereas the CC50 value for SLN/TW-1.5 was 45.2 µg∙mL−1. Electron Paramagnetic Resonance (EPR) showed a marked in vitro antioxidant activity for BBI and SLN/TW-1.5. After in vivo SLN/TW-1.5 administration in Zophobas morio larvae, assessment of reduced glutathione (GSH), nitrite (NO2−) and myeloperoxidase (MPO) demonstrated antioxidant activity. Thus, the intrinsic physicochemical properties of BBI allowed the development of an optimized nanoformulation with high stability indexes, besides the great potential for antioxidant applications