Information Literacy for Branch Campuses and Branch Libraries

Although information literacy objectives are a constant, teaching methods and pedagogy must be structured differently in different teaching-learning environments. The Libraries of Indiana University of Pennsylvania (IUP) created a new model of library instruction for its branch libraries and branch campuses, based on the embedded or college librarian model. Librarians for music, science, education, and the IUP Northpointe campus have been integrated into the instruction and curricular activities of those locations, some of which include distance education programs. While this model has logistical and political challenges, it has proved beneficial in improving information literacy for both faculty and students, and for providing visibility, opportunities, and recognition for library faculty

Information Literacy for Branch Campuses and Branch Libraries

Although information literacy objectives are a constant, teaching methods and pedagogy must be structured differently in different teaching-learning environments. The Libraries of Indiana University of Pennsylvania (IUP) created a new model of library instruction for its branch libraries and branch campuses, based on the embedded or college librarian model. Librarians for music, science, education, and the IUP Northpointe campus have been integrated into the instruction and curricular activities of those locations, some of which include distance education programs. While this model has logistical and political challenges, it has proved beneficial in improving information literacy for both faculty and students, and for providing visibility, opportunities, and recognition for library faculty

Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development

AbstractThe development of the Drosophila visual system utilizes two members of the highly conserved Six-Homeobox family of transcription factor, Sine oculis and Optix. Although in vitro studies have detected differences in DNA-binding and interactions with some co-factors, questions remain as to what extent the activity for these two transcriptional regulators is redundant or specific in vivo. In this work, we show that the SoD mutation within the Six domain does not abolish DNA–protein interactions, but alters co-factor binding specificity to resemble that of Optix. A mutation in the same region of Optix alters its activity in vivo. We propose that the dominant mutant phenotype is primarily due to an alteration in binding properties of the Sine oculis protein and that distinct partner interactions is one important mechanism in determining significant functional differences between these highly conserved factors during eye development

B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma

In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis that B and plasma cells are free to migrate through the mucosal surfaces of the upper and lower respiratory tracts, and that their total antibody repertoire is modified in a common respiratory tract disease, in this case atopic asthma. Using Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) we have catalogued the antibody repertoires of B cell clones retrieved near contemporaneously from multiple sites in the upper and lower respiratory tract mucosa of adult volunteers with atopic asthma and non-atopic controls and traced their migration. We show that the lower and upper respiratory tracts are immunologically connected, with trafficking of B cells directionally biased from the upper to the lower respiratory tract and points of selection when migrating from the nasal mucosa and into the bronchial mucosa. The repertoires are characterized by both IgD-only B cells and others undergoing class switch recombination, with restriction of the antibody repertoire distinct in asthmatics compared with controls. We conclude that B cells and plasma cells migrate freely throughout the respiratory tract and exhibit distinct antibody repertoires in health and disease