Pyothorax and pulmonary lymphomatoid granulomatosis in a cat

A 7-year-old female neutered British Short Hair cat was presented for further investigation and treatment of pleural effusion due to a possible pyothorax. Cytology and culture of the fluid identified pyothorax and a large mass/consolidated right caudal lung lobe was found on x-ray, ultrasound and CT scan. Lung lobectomy was performed and a diagnosis of pulmonary lymphomatoid granulomatosis (PLG) was confirmed by histopathology and immunohistochemistry. Despite medical treatment the patient was euthanized due to progression of the disease and deterioration of her clinical signs. This is the second case of PLG reported in a cat and the first case of PLG with concurrent pyothorax. PLG, despite being very rare, should be added to the list of differential diagnoses for pyothorax and solitary lung masses in cats.Non

Myoclonus and hypercalcemia in a dog with poorly differentiated lymphoproliferative neoplasia.

A 1-year, 8-month-old Rhodesian Ridgeback was presented with obtundation, ambulatory tetraparesis, and myoclonus. Initial clinical findings included ionized hypercalcemia with an apparent marked increase in parathyroid hormone, thrombocytopenia, and nonregenerative anemia. Low numbers of circulating atypical cells were noted on blood film evaluation. Brain magnetic resonance imaging identified an extra-axial contrast enhancing subtentorial lesion, and cerebrospinal fluid (CSF) analysis documented a marked atypical lymphocytic pleocytosis. Flow cytometry performed on the CSF demonstrated expression of only CD45, CD90, and MHC class II, with Pax5 positivity on subsequent immunohistochemistry. The final diagnosis was of B-cell lymphoblastic lymphoma or acute leukemia, given the distribution of disease and the presence of significant bone marrow infiltration alongside an aggressive clinical course. The unusual immunophenotype of the neoplastic cells and hypercalcemia presented antemortem diagnostic challenges, highlighting the need for a multidisciplinary approach and caution in the interpretation of clinical abnormalities in cases with multiple comorbidities