Comparison of Protocols to Reduce Diabetic Ketoacidosis in Patients With Type 1 Diabetes Prescribed a Sodium–Glucose Cotransporter 2 Inhibitor

OBJECTIVE Sodium–glucose cotransporter 2 (SGLT2) inhibitors are approved for type 1 diabetes in Europe and Japan, with off-label use in type 1 diabetes in the United States. Although there were no consistent approaches to risk mitigation in clinical trials of these agents, protocols have been developed to try to reduce the risk of diabetic ketoacidosis (DKA). However, a validated risk mitigation strategy does not exist. We reviewed available DKA risk mitigation protocols to better understand the various strategies currently in use. METHODS We conducted a search of the published medical literature and other medical information sources, including conference presentations, for protocols. We then categorized the information provided into guidance on patient se-lection, initiation of SGLT2 inhibitors, ketone monitoring, necessary patient action in the event of ketosis or DKA, and inpatient treatment of ketosis or DKA. RESULTS Patient selection is generally similar among the protocols, although some require a minimum BMI and insulin dose. All protocols advocate routine measurement of ketones, although some insist on blood ketone tests. Although action steps for ketosis varies, all protocols advocate rapid patient intervention. The importance of evaluating ketones and acid-base balance even in the absence of hyperglycemia is emphasized by all protocols, as is the need to continue administering insulin until ketosis has resolved. CONCLUSION DKA risk mitigation must be pursued systematically in individuals with type 1 diabetes, although the best strategy remains to be determined. Given the ongoing need for adjunctive therapies in type 1 diabetes and current use of SGLT2 inhibitors for this purpose, additional education and research are crucial, especially in the hospital environment, where DKA may not be diagnosed promptly and treated appropriately

g_{rho sigma gamma} coupling constant in light cone QCD

The coupling constant g_{rho sigma gamma} is determined from light cone QCD sum rules. A comparison of our result with the ones existing in literature is presented.Comment: 7 pp, 2 figures (postscript formatted), LaTex formatte

A partial wave analysis of the centrally produced pi+pi- system in pp interactions at 450 GeV/c

A partial wave analysis of the centrally produced pi+pi- channel has been performed in pp collisions using an incident beam momentum of 450 GeV/c. An unambiguous physical solution has been found. Evidence is found for the f0(980), f0(1300), f0(1500) and fJ(1710) with J = 0 in the the S-wave. The rho(770) is observed dominantly in the P0-wave and the f2(1270) is observed dominantly in the D0-wave. In addition, there is evidence for a broad enhancement in the D-wave below 1 GeV.Comment: 12 pages, Latex, 4 Figure

A partial wave analysis of the centrally produced pi0pi0 system in pp interactions at 450 GeV/c

A partial wave analysis of the centrally produced pi0pi0 channel has been performed in pp collisions using an incident beam momentum of 450 GeV/c. An unambiguous physical solution has been found. Evidence is found for the f0(980), f0(1300) and f0(1500) in the the S-wave. and the f2(1270) is observed dominantly in the D0-wave. In addition, there is evidence for a broad enhancement in the D-wave below 1 GeV.Comment: 12 pages, Latex, 4 Figure

Determining the upper limit of Gamma_{ee} for the Y(4260)

By fitting the R values between 3.7 and 5.0 GeV measured by the BES collaboration, the upper limit of the electron width of the newly discovered resonance Y(4260) is determined to be 580 eV at 90% C.L. Together with the BABAR measurement on the product of Gamma_{ee} and BR(Y(4260) --> pi+pi- J/psi), this implies a large decay width of Y(4260) --> pi+pi- J/psi final states.Comment: 8 pages, 4 figure

Interactions between brown-dwarf binaries and Sun-like stars

Several mechanisms have been proposed for the formation of brown dwarfs, but there is as yet no consensus as to which -- if any -- are operative in nature. Any theory of brown dwarf formation must explain the observed statistics of brown dwarfs. These statistics are limited by selection effects, but they are becoming increasingly discriminating. In particular, it appears (a) that brown dwarfs that are secondaries to Sun-like stars tend to be on wide orbits, a\ga 100\,{\rm AU} (the Brown Dwarf Desert), and (b) that these brown dwarfs have a significantly higher chance of being in a close (a\la 10\,{\rm AU}) binary system with another brown dwarf than do brown dwarfs in the field. This then raises the issue of whether these brown dwarfs have formed {\it in situ}, i.e. by fragmentation of a circumstellar disc; or have formed elsewhere and subsequently been captured. We present numerical simulations of the purely gravitational interaction between a close brown-dwarf binary and a Sun-like star. These simulations demonstrate that such interactions have a negligible chance ($<0.001$) of leading to the close brown-dwarf binary being captured by the Sun-like star. Making the interactions dissipative by invoking the hydrodynamic effects of attendant discs might alter this conclusion. However, in order to explain the above statistics, this dissipation would have to favour the capture of brown-dwarf binaries over single brown-dwarfs, and we present arguments why this is unlikely. The simplest inference is that most brown-dwarf binaries -- and therefore possibly also most single brown dwarfs -- form by fragmentation of circumstellar discs around Sun-like protostars, with some of them subsequently being ejected into the field.Comment: 10 pages, 8 figures, Accepted for publication in Astrophysics and Space Scienc

A measurement of the branching fractions of the f1(1285) and f1(1420) produced in central pp interactions at 450 GeV/c

A study of the f1(1285) and f1(1420) produced in central pp interactions has been performed. For the first time in a single experiment the branching fractions of both mesons in all major decay modes have been determined. Both the f1(1285) and f1(1420) are consistent with being produced by double Pomeron exchange.Comment: 15 pages, Latex, 5 Figures, submitted to Physics Letters

A study of the centrally produced phiphi system in pp interactions at 450 GeV/c

The reaction pp to pfps(K+K-K+K-) in which the K+K-K+K- system is centrally produced has been studied at 450 GeV/c. Phi phi production has been found to dominate this reaction and is compatible with being produced by double Pomeron exchange. An angular analysis of the phi phi system favours JPC = 2++ and its dPT dependence is similar to that observed for glueball candidates.Comment: 11 pages, Latex, 4 Figure

A partial wave analysis of the centrally produced K+K- and K0K0 systems in pp interactions at 450 GeV/c and new information on the spin of the fJ(1710)

A partial wave analysis of the centrally produced K+K- and K0K0 channels has been performed in pp collisions using an incident beam momentum of 450 GeV/c. An unambiguous physical solution has been found in each channel. The striking feature is the observation of peaks in the S-wave corresponding to the f0(1500) and fJ(1710) with J = 0. The D-wave shows evidence for the f2(1270)/a2(1320), the f2(1525) and the f2(2150) but there is no evidence for a statistically significant contribution in the D-wave in the 1.7 GeV mass region.Comment: 15 pages, Latex, 5 Figure

A study of the centrally produced baryon-antibaryon systems in pp interactions at 450 GeV/c

A study of the centrally produced ppbar, ppbarpi, ppbarpipi and lambda lambda channels has been performed in pp collisions using an incident beam momentum of 450 GeV/c. No significant new structures are observed in the mass spectra, however, important new information on the production dynamics is obtained. A systematic study of the production properties of these systems has been performed and it is found that these systems are not produced dominantly by double Pomeron exchange.Comment: 13 pages, Latex, 4 Figure