Developing a School-Based Multi-Tiered Model for Self-Regulation

Self-regulation is the control mechanism that enables a student to manage attention, emotion, behavior and cognition to engage in goal-directed actions, like learning. Too often, students at- risk for poor school outcomes do not enter school with strongly developed self-regulation skills and have difficulty developing them on their own. Self-regulation skills can be taught however, and are especially effective when introduced within the school setting. This manuscript describes a school based model for fostering self-regulation. We created the model within the Multi-Tiered Systems of Support (MTSS) framework, to facilitate successful implementation

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

Studying cancer metabolism gives insight into tumorigenic survival mechanisms and susceptibilities. In melanoma, we identify HEXIM1, a transcription elongation regulator, as a melanoma tumor suppressor that responds to nucleotide stress. HEXIM1 expression is low in melanoma. Its overexpression in a zebrafish melanoma model suppresses cancer formation, while its inactivation accelerates tumor onset in vivo. Knockdown of HEXIM1 rescues zebrafish neural crest defects and human melanoma proliferation defects that arise from nucleotide depletion. Under nucleotide stress, HEXIM1 is induced to form an inhibitory complex with P-TEFb, the kinase that initiates transcription elongation, to inhibit elongation at tumorigenic genes. The resulting alteration in gene expression also causes anti-tumorigenic RNAs to bind to and be stabilized by HEXIM1. HEXIM1 plays an important role in inhibiting cancer cell-specific gene transcription while also facilitating anti-cancer gene expression. Our study reveals an important role for HEXIM1 in coupling nucleotide metabolism with transcriptional regulation in melanoma

Identification and Evaluation of Learning Disabilities: The School Team\u27s Guide to Student Success

When it comes to designing assessment and instruction for students with learning disabilities, one size does not fit all—and that\u27s also true for identifying and evaluating learning disabilities. Theories and legislation aside, it\u27s critical for your school team to have a comprehensive plan to make sure every child gets the right kind of attention—and no one falls through the cracks. This compelling, easy-to-use handbook guides general educators, special educators, administrators, and school psychologists through the stages of eligibility and evaluation to ensure that every student gets the best services and interventions. You\u27ll find Guidance on what data to collect and how to collect it Strategies for combining RTI with a comprehensive evaluation to diagnose specific learning disabilities Detailed case studies—with graphs, figures, and test scores—at the school, classroom, and individual student level Everyone on your team has the same goal: to help students with learning challenges achieve success. This comprehensive resource provides the tools you need to make that happen.https://scholarworks.boisestate.edu/fac_books/1393/thumbnail.jp

A Self-Regulated Learner Framework for Students with Learning Disabilities and Math Anxiety

Students with math learning disabilities have been shown to experience math anxiety at rates nearly double those of their typical peers. Anxiety about math is thought to disrupt learning by co-opting attentional resources that could be used in problem-solving and may be caused by the way in which students interpret their math-related experiences. This article describes a math intervention designed through a framework of self-regulated learning that defines self-regulated learners as students who are connected, self-aware, self-determined, strategic, and resilient. Specifically described is an intervention that helps students regulate anxiety, initiate a problem-solving strategy, and advocate as needed to use approaches they find effective

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

International audienceStudying cancer metabolism gives insight into tumorigenic survival mechanisms and susceptibilities. In melanoma, we identify HEXIM1, a transcription elongation regulator, as a melanoma tumor suppressor that responds to nucleotide stress. HEXIM1 expression is low in melanoma. Its overexpression in a zebrafish melanoma model suppresses cancer formation, while its inactivation accelerates tumor onset in vivo. Knockdown of HEXIM1 rescues zebrafish neural crest defects and human melanoma proliferation defects that arise from nucleotide depletion. Under nucleotide stress, HEXIM1 is induced to form an inhibitory complex with P-TEFb, the kinase that initiates transcription elongation, to inhibit elongation at tumorigenic genes. The resulting alteration in gene expression also causes anti-tumorigenic RNAs to bind to and be stabilized by HEXIM1. HEXIM1 plays an important role in inhibiting cancer cell-specific gene transcription while also facilitating anti-cancer gene expression. Our study reveals an important role for HEXIM1 in coupling nucleotide metabolism with transcriptional regulation in melanoma