Algebraic description of spacetime foam

A mathematical formalism for treating spacetime topology as a quantum observable is provided. We describe spacetime foam entirely in algebraic terms. To implement the correspondence principle we express the classical spacetime manifold of general relativity and the commutative coordinates of its events by means of appropriate limit constructions.Comment: 34 pages, LaTeX2e, the section concerning classical spacetimes in the limit essentially correcte

Use and attitudes of obstetricians toward 3 high-risk interventions in MFMU Network hospitals

We sought to evaluate the frequency of, and factors associated with, the use of 3 evidence-based interventions: antenatal corticosteroids for fetal lung maturity, progesterone for prevention of recurrent preterm birth, and magnesium sulfate for fetal neuroprotection

The Complete Genome Sequence of ‘Candidatus Liberibacter solanacearum’, the Bacterium Associated with Potato Zebra Chip Disease

Zebra Chip (ZC) is an emerging plant disease that causes aboveground decline of potato shoots and generally results in unusable tubers. This disease has led to multi-million dollar losses for growers in the central and western United States over the past decade and impacts the livelihood of potato farmers in Mexico and New Zealand. ZC is associated with ‘Candidatus Liberibacter solanacearum’, a fastidious alpha-proteobacterium that is transmitted by a phloem-feeding psyllid vector, Bactericera cockerelli Sulc. Research on this disease has been hampered by a lack of robust culture methods and paucity of genome sequence information for ‘Ca. L. solanacearum’. Here we present the sequence of the 1.26 Mbp metagenome of ‘Ca. L. solanacearum’, based on DNA isolated from potato psyllids. The coding inventory of the ‘Ca. L. solanacearum’ genome was analyzed and compared to related Rhizobiaceae to better understand ‘Ca. L. solanacearum’ physiology and identify potential targets to develop improved treatment strategies. This analysis revealed a number of unique transporters and pathways, all potentially contributing to ZC pathogenesis. Some of these factors may have been acquired through horizontal gene transfer. Taxonomically, ‘Ca. L. solanacearum’ is related to ‘Ca. L. asiaticus’, a suspected causative agent of citrus huanglongbing, yet many genome rearrangements and several gene gains/losses are evident when comparing these two Liberibacter. species. Relative to ‘Ca. L. asiaticus’, ‘Ca. L. solanacearum’ probably has reduced capacity for nucleic acid modification, increased amino acid and vitamin biosynthesis functionalities, and gained a high-affinity iron transport system characteristic of several pathogenic microbes

Recovery of force-time characteristics after Australian rules football matches : examining the utility of the isometric midthigh pull

Purpose: This study assessed the utility of force-time characteristics from the isometric midthigh pull (IMTP) as a measure of neuromuscular function after elite-level Australian rules football matches. It was hypothesized that rate characteristics of force development would demonstrate a different response magnitude and recovery time course than peak force measurements. Methods: Force-time characteristics of the IMTP (peak force, 0- to 50-ms rate of force development [RFD], 100- to 200-ms RFD) were collected at 48 (G+2), 72 (G+3), and 96 h (G+4) after 3 competitive Australian rules football matches. Results: Meaningful reductions (>75% of the smallest worthwhile change) were observed at G+2, G+3, and G+4 for RFD 0-50 milliseconds (-25.8%, -17.5%, and -16.9%) and at G+2 and G+3 for RFD 100-200 milliseconds (-15.7% and -11.7%). No meaningful reductions were observed for peak force at any time point (G+2 -4.0%, G+3 -3.9%, G+4 -2.7%). Higher week-to-week variation was observed for RFD 0-50 milliseconds (G+2 17.1%, G+3 27.2%, G+4 19.3%) vs both RFD 100-200 milliseconds (G+2 11.3%, G+3 11.5%, G+4 7.2%) and peak force (G+2 4.8%, G+3 4.4%, G+4 8.4%). Conclusions: These findings highlight the potential use of rate characteristics from the IMTP as measures of neuromuscular function in elite sport settings, and in particular RFD 100-200 milliseconds due to its higher reliability. Interestingly, peak force collected from the IMTP was not meaningfully suppressed at any time point after elite Australian rules football match play. This suggests that rate characteristics from IMTP may provide more sensitive and valuable insight regarding neuromuscular function recovery kinetics than peak measures