Mitochondrial genome-wide <i>P</i> values after adjusting for multiple testing.

<p>On the y axis, adjusted p-values transformed into the negative of the base 10 logarithm, −log₁₀(p-value), are shown. The x-axis represents the mitochondrial genome, displaying the position and relative size of each of the 13 major mitochondrial genes, 12S and 16S rRNAs, hypervariable region 1 (HVRI), hypervariable region 2 (HVR II) as well as the position of the 22 tRNAs (gray). The dashed lines show the critical values of the pointwise significance level corresponding to an FDR of 0.05.</p

Summary of the quality control.

<p>The number of <b>mtSNPs</b> refers to the SNPs that passed QC and were included in the analysis. Several mtSNPs were excluded due to the upper bound cut-off (<b>UB</b>) or because the basepair position was not available in Build 38 (<b>no_B38</b>). Sample size is based on the particular chip. One person may be present on more than one chip. <i>I_SNP</i> stands for the number of intensity measures per allele. <i>I_tot</i> represents the total number of intensity measures in the sample (I_SNP*2*sample-size*mtSNPs).</p

Summary of significant mtSNPs.

<p>Genomic position in base pairs (bp), alleles, rs_number, and type of mutation are based on the NCBI dbSNP GRCh38 human genome assembly (rCRS, GeneBank ID J01415.2). Alleles are given in terms of major→minor allele. An estimated effect size (β_SNP)<0 indicates that the minor allele increases BMI. Nominal p-values and adjusted p-values are provided.</p

Distribution of characteristics of the study population.

<p>The mtSNPs column shows the number of mitochondrial SNPs provided by each chip. Distributions are presented as means ± standard deviation.</p

Coverage of the mitochondrial genome provided by each genotyping chip.

<p>Each vertical bar stands for one mtSNP. The x-axis represents the mitochondrial genome, displaying the position and relative size of each of the 13 major mitochondrial genes, 12S and 16S rRNAs, hypervariable region 1 (HVRI), hypervariable region 2 (HVR II) as well as the position of the 22 tRNAs.</p

Additional file 1: of pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms

Theory underlying pulver. This file describes the derivation of the t-value computed from the beta value divided by the standard error and the correlation value. (PDF 426 kb