PENGEMBANGAN LEMBAR KERJA MAHASISWA (LKM) TERMOKIMIA BERBASIS TUGAS DIMASA PANDEMI COVID-19 DALAM MATA KULIAH KIMIA FISIKA FKIP KIMIA UNIVERSITAS SRIWIJAYA

Penelitian pengembangan ini bertujuan untuk menghasilkan produk berupa Lembar Kerja Mahasiswa yang berbasis tugas pada mata Kuliah Kimia Fisika yang valid dan praktis. Penelitian ini menggunakan model pengembangan ADDIE yang meliputi Analysis, Design, Development, Implementation, Evaluation dan dievaluasi dengan menggunakan metode evaluasi formatif Tessmer. Tahapan dari evaluasi formatif Tessmer dalam penelitian ini terdiri dari self evaluation, expert review, one-to-one dan small group. Uji Validitas produk LKM dilakukan dengan pengumpulan data dari dosen ahli (validator) dan mahasiswa- mahasiswa yang telah mengikuti mata kuliah Kimia Fisika dengan menggunakan instrumen angket. Berdasarkan analisa data hasil tahap expert review dengan skor rata-rata kevalidan sebesar 0,80 dengan kategori sangat valid. Untuk skor akhir kepraktisan didapatkan dari uji coba one-to-one sebesar 0,87 (sangat praktis) dan uji coba small group 0,87 (sangat praktis). Berdasarkan hasil tersebut menunjukkan bahwa lembar kerja mahasiswa Termokimia berbasis tugas yang dihasilkan telah memenuhi kategori valid dan praktis. Kata kunci: Penelitian Pengembangan, lembar kerja mahasiswa berbasis tugas, Termokimia

The Association of Preoperative Magnetic Resonance Imaging (MRI) With Surgical Management in Patients With Early-Stage Breast Cancer

The rate of mastectomy in lumpectomy-eligible patients with unilateral breast cancer is increasing. We sought to investigate the association between magnetic resonance imaging (MRI) and surgical management of patients with early-stage breast cancer by comparing the rate of mastectomy as first surgery in patients with and without preoperative MRI.A bi-institutional retrospective study included patients diagnosed between 2016 and 2020. Lumpectomy-eligible patients with in situ and invasive cancer were included. Those receiving preoperative therapy, MRI before diagnosis, or with known bilateral cancer were excluded. The risk factors for bilateral and multicentric disease were accounted for. Fisher's exact and chi-square tests compared categorical variables, Wilcoxon two-sample test analyzed continuous variables, and multivariate analyses were performed with Poisson regression.Four hundred twenty-eight participants met inclusion criteria. Patients who received MRI were younger (58 versus 67 y; P < 0.001) and had denser breasts (group 3 or 4; 61% versus 25%; P < 0.001). Mastectomy rate was twice as high in patients undergoing MRI (32% versus 15%, rate ratio 2.16; P < 0.001), which remained significant in multivariate analysis (rate ratio 2.0; P < 0.001). Contralateral mastectomy (12% versus 4%; P = 0.466) and reexcision (13% versus 12%; P = 0.519) rates were similar. Time to surgery was greater in those receiving MRI alone and MRI biopsy (34 [no MRI] versus 45 [MRI] versus 62 [MRI biopsy]; P < 0.001 for both).MRI receipt is associated with a doubled rate of mastectomy in lumpectomy-eligible patients. Future work is needed to standardize patient selection for MRI to those with the highest likelihood of having additional undiagnosed disease