Representation of the CYP 2C19.

<p>Area covered (depicted as <i>light blue</i> transparent <i>solid surface</i>) by the two internal cavities (catalytic site cavity and adjacent cavity) of human microsomal cytochrome P450 (CYP) 2C19 (<i>brown</i>). The heme prosthetic group is represented in <i>green</i> and the molecule of dapsone in the color <i>red</i> (<b>a</b>). Delimitation of the area occupied by the two internal cavities (catalytic site cavity and adjacent cavity) of the CYP2C19 (<b>b</b>).</p

Determination of nitric oxide (NO) in serum (a), percentage of blood methemoglobin (b) levels of malondialdehyde (MDA) in plasma (c) of patients with untreated leprosy (MDT 0) and after the third dose supervised treatment (MDT 3).

<p>Figures in the chart are expressed as mean ± SD. *p<0.05 compared to MDT0 (ANOVA).</p

Analysis of anti-PGL-I ELISA titer of 146 individuals based on group behaviors.

<p>Behaviors were associated with the type of contact with armadillos, including A) hunting armadillos in the forest, B) handling or preparing armadillo meat for cooking or consumption, C) eating armadillo meat and D) frequency of consuming armadillos in the diet.</p

Map of study area.

<p>Municipality of Belterra in western Pará, and the villages of São Jorge at Km 92 and Corpus Christi at Km 135 on the Santarém-Cuiabá highway.</p

Risk factors associated with leprosy patients living in rural communities in the municipality of Belterra, Pará.

<p>Risk factors associated with leprosy patients living in rural communities in the municipality of Belterra, Pará.</p

Staining of mycobacteria <i>in situ</i> in <i>M</i>. <i>leprae</i> infected armadillo spleen sections.

<p>A) SYBR Gold staining (blue) of <i>M</i>. <i>leprae</i> in armadillo spleen A7, arrow denotes stained bacillus. Insert, enlarged area showing stained bacillus. B) SYBR Gold staining (green) of <i>M</i>. <i>leprae</i> in armadillo spleen B7. Arrow denotes stained cluster of bacilli, enlarged in insert. C) Auramine/rhodamine stained cluster (red) of bacilli (arrow) located within an apoptotic cell next to a cell-free necrotic zone (*) in armadillo spleen A7.</p

Hematoxylin and eosin (H&E) and Fite Faraco (acid fast) staining of non-infected and infected armadillo spleen sections.

<p>A) Non-infected control NHDP armadillo spleen (13–02) stained by H&E to show normal splenic architecture; B) <i>M</i>. <i>leprae</i> infected NHDP armadillo spleen (11I302) stained by H&E; C) Non-infected control NHDP armadillo spleen (12–70) stained by Fite Faraco method showing only counterstain; D) Many acid fast bacilli (red clusters) in <i>M</i>. <i>leprae</i> infected NHDP armadillo spleen (11I302) revealed by Fite Faraco stain; E) Wild armadillo (A2) spleen section stained with Fite Faraco, arrow pointing to acid fast bacilli at lower magnification and enlarged in insert; F) Wild armadillo (A2) spleen section stained with Fite Faraco revealing clusters of acid fast bacilli (arrows).</p

<i>Cyphellophora ludoviensis</i> microscopic morphology.

<p>(A) colonies on SGA; (B-E) hyphae with chlamydospores and lateral extensions; (F) anastomosis; (G-H) spirally twisted hyphae; (I) poorly differentiated phialide producing conidia; (J-P) chlamydospores and conidia. Scale bars 10 μm.</p