Estimated median (95% CI) CD4 cell count by HIV-1 subtype and time since cART initiation.

<p>(Non acute infection, without AIDS at cART initiation, boosted PI cART, seroconversion to cART >4 years, previously naïve, ≥5 log₁₀ c/ml initial viral load, men having sex with men, 30 years old at cART initiation).</p

Cumulative incidence of initial virologic response (A) and virologic failure (B) by HIV-1 subtype.

<p>Numbers below each subfigure indicate numbers of individuals “at risk” (i.e. subjects not responded (A) or failed (B) and under follow-up).</p

Factors associated with cause-specific hazard of initial virologic response and virologic failure after cART initiation.

1<p>: men having sex with men;²: injecting drug users;³: sex between men and women. Each factor is adjusted for all other factors in Table.</p>*<p>global Wald-type tests based on the fit of the corresponding models.</p

Observed (A) and predicted (B) CD4 cell count by HIV-1 subtype.

<p>A: Median profiles (numbers on top indicate individuals contributing measurements at each time point), B: based on a piecewise linear mixed model (Non acute infection, without AIDS at cART initiation, boosted PI cART, SC to cART>4 years, previously naïve, 5 log₁₀ c/ml initial viral load, men having sex with men, 30 years old at cART initiation).</p