Insulin secretion in insulin sensitive and resistant cases and controls.

<p>Fasting and total insulin secretion (box and whiskers, min to max) in control and PCOS women having insulin resistance defined as HOMA-IR ≥1.26 (panel A); insulin sensitivity defined as WBISI ≥7.91 (panel B) and insulin resistance as WBISI<7.91 (panel C).</p

Relationship between insulin sensitivity and secretion in cases and controls.

<p>Scatter plot of the relationship between whole body insulin sensitivity (WBISI) and Total insulin secretion in controls (empty circles) and patients with PCOS (filled circles).</p

Coefficients of correlation in patients with PCOS.

<p>A4, Androstenedione; AMH, Anti-Mullerian Hormone; BMI, body Mass Index;</p><p>CBG, Cortisol Binding Globulin; DHEAS, Dehydroepiandrosterone sulfate; E2, 17β-estradiol;</p><p>HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; LH, Luteinizing Hormone;</p><p>FAI, Free androgen index; FSH, follicle-stimulating hormone; T, testosterone; WBISI, Whole Body Insulin Sensitivity Index; ISSI-2, Insulin.</p

Anthropometrics, laboratory and insulin metabolism related parameters of controls and PCOS patients according to the obesity status.

<p>Data are expressed as mean ± SD. <i>P</i> refers to statistical significance at the Mann-Whitney U test within groups of normal-weight, overweight and obese women. BMI, body Mass Index; HDL, High density lipoprotein; HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; LDL, Low density lipoprotein; WBISI, Whole Body Insulin Sensitivity Index; ISSI-2, Insulin Secretion-Sensitivity Index-2; Total Insulin, Total insulin secretion at a WBISI of 5.</p

Relative frequency of single cardiometabolic risk factors in children with severe obesity defined according to BMI-for-age ≥99^th percentile or ≥1.2 times the 95^th percentile, by CDC or WHO.

<p>Relative frequency of single cardiometabolic risk factors in children with severe obesity defined according to BMI-for-age ≥99^th percentile or ≥1.2 times the 95^th percentile, by CDC or WHO.</p

Anthropometric characteristics and cardiometabolic profile of the total study population and of groups stratified by gender and age.

<p>Comparison between genders * p<0.04; **p<0.001.</p><p>Comparison between age class # p<0.04; ≠p<0.03; ^§p<0.001.</p><p>BMI, Body Mass Index; OW, overweight; Mod-OB, Moderate Obesity; Sev-OB, Severe Obesity; CDC, Centers for Disease Control and Prevention; WHO, World Health Organization; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglycerides.</p

AUROC, sensitivity, specificity, PPV, NPV, LR⁺, LR⁻ and kappa of categories of severe obesity defined as BMI ≥1.2 times the 95^th percentile by CDC or WHO for predicting clustered cardiometabolic risk in the total sample and in groups stratified by gender and age.

<p>AUROC, Area Under the Receiver Operating characteristic Curve; PPV, Positive Predictive Value; NPV, Negative Predictive Value; LR, Likelihood Ratio; CDC, Centers for Disease Control and Prevention; WHO, World Health Organization; BMI, Body mass Index; CI, Confidence Interval.</p