Clinical Uses for Psychedelic Drugs

Throughout the last forty years, psychedelic drugs have been illegal in the United States. Stigmatized due to the potential for abuse, the use of these drugs has been relegated to simple criminal activity and research stagnated for those 40 years. Slowly, research has begun to pick up as the restrictions begin to lift incrementally. However, the current restrictions are intense, further limiting the amount of research conducted that can reveal the medical benefits of these drugs. Through multiple studies, both open-label and double-blinded to show both feasibility and efficacy, as well as the biological impact of the drugs, significant anxiolytic, antidepressant, and anti-addictive effects of hallucinogens have been demonstrated. The medical use of these drugs could have a lasting effect regarding substance abuse addictions, severe cases of anxiety, and treatment resistant depression providing alternatives to current methods of treatment

Aerobic exercise with blood flow restriction for patients undergoing dialysis

This study demonstrated that blood flow restriction aerobic exercise performed during dialysis is both haemodynamically safe and efficacious for enhancing strength and physical function among patients with end-stage kidney disease. The findings positively support blood flow restriction as an adjunct to exercise for dialysis patients afflicted with marked physical impairment

Approach for power scaling solid-state lasers with intracavity motion

Solid-state lasers are typically limited by adverse thermal effects within the gain medium. In this paper we describe a new method for dramatically reducing thermal effects in an end-pumped solid-state laser by incorporating a rotating intracavity periscope in the resonator to spatially separate the lasing and thermal processes. In contrast to previous examples of moving solid-state lasers our approach keeps the gain medium stationary simplifying the heat removal arrangement. This scheme has been applied to a Nd:YAG laser yielding an output power of 120 W at 1.064 µm, limited by available pump power. Analysis suggests that scaling to much higher power is feasible with the appropriate laser design

The Effect of Luminance on Depth Perception in Augmented Reality Guided Laparoscopic Surgery

Depth perception is a major issue in surgical augmented reality (AR) with limited research conducted in this scientific area. This study establishes a relationship between luminance and depth perception. This can be used to improve visualisation design for AR overlay in laparoscopic surgery, providing surgeons a more accurate perception of the anatomy intraoperatively. Two experiments were conducted to determine this relationship. First, an online study with 59 participants from the general public, and second, an in-person study with 10 surgeons as participants. We developed 2 open-source software tools utilising SciKit-Surgery libraries to enable these studies and any future research. Our findings demonstrate that the higher the relative luminance, the closer a structure is perceived to the operating camera. Furthermore, the higher the luminance contrast between the two structures, the higher the depth distance perceived. The quantitative results from both experiments are in agreement, indicating that online recruitment of the general public can be helpful in similar studies. An observation made by the surgeons from the in-person study was that the light source used in laparoscopic surgery plays a role in depth perception. This is due to its varying positioning and brightness which could affect the perception of the overlaid AR. We found that luminance directly correlates with depth perception for both surgeons and the general public, regardless of other depth cues. Future research may focus on comparing different colours used in surgical AR and using a mock operating room (OR) with varying light sources and positions

Spectral imaging of thermal damage induced during microwave ablation in the liver

Induction of thermal damage to tissue through delivery of microwave energy is frequently applied in surgery to destroy diseased tissue such as cancer cells. Minimization of unwanted harm to healthy tissue is still achieved subjectively, and the surgeon has few tools at their disposal to monitor the spread of the induced damage. This work describes the use of optical methods to monitor the time course of changes to the tissue during delivery of microwave energy in the porcine liver. Multispectral imaging and diffuse reflectance spectroscopy are used to monitor temporal changes in optical properties in parallel with thermal imaging. The results demonstrate the ability to monitor the spatial extent of thermal damage on a whole organ, including possible secondary effects due to vascular damage. Future applications of this type of imaging may see the multispectral data used as a feedback mechanism to avoid collateral damage to critical healthy structures and to potentially verify sufficient application of energy to the diseased tissue.Comment: 4pg,6fig. Copyright 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other work

The perspectives of UK personnel towards current killing practices for laboratory rodents

Data supporting manuscript entitled 'The perspectives of UK personnel towards current killing practices for laboratory rodents.

Fan-Slicer: A Pycuda Package for Fast Reslicing of Ultrasound Shaped Planes

Fan-Slicer (https://github.com/UCL/fan-slicer) is a Python package that enables the fast sampling (slicing) of 2D ultrasound-shaped images from a 3D volume. To increase sampling speed, CUDA kernel functions are used in conjunction with the Pycuda package. The main features include functions to generate images from both 3D surface models and 3D volumes. Additionally, the package also allows for the sampling of images from curvilinear (fan shaped planes) and linear (rectangle shaped planes) ultrasound transducers. Potential uses of Fan-slicer include the generation of large datasets of 2D images from 3D volumes and the simulation of intra-operative data among others