Identical Response of Caged Rock Crabs (Genera Metacarcinus and Cancer) to Energized and Unenergized Undersea Power Cables in Southern California, USA

Energy generation facilities (i.e., wave and wind) are being sited in offshore marine waters. The electricity generated from these facilities is transmitted to shore through cables carrying alternating or direct current. This current produces an electromagnetic field (EMF) that is emitted from the cable. Concerns have been voiced regarding how marine organisms, in this instance crabs, respond to the EMF emitted by submarine power cables. Two submarine cables, one energized and the other unenergized, and separated by about 7 m, were used in the experiment. Crabs (Metacarcinus anthonyi (Rathbun, 1897) and Cancer productus (Randall, 1839)) were placed in plastic perforated boxes secured to the sea floor with one end in contact with one of the two cables. After one hour and 24 hours, scuba divers ascertained the position of the crabs within the boxes, these positions designated as either “near-half” or “far-half.” EMF readings were taken on the floor of each box at the edge closest to the cable and on the floor of that box furthest from the cable at one and 24 hours. Within the boxes, EMF levels were between 46.2–80.0 microteslas next to the cable an

Membrane Microviscosity Modulates Μ-Opioid Receptor Conformational Transitions and Agonist Efficacy

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66282/1/j.1471-4159.1999.0730289.x.pd

Translation Of Interpersonal Support Evaluation List (ISEL) And Coping Self-Efficacy (CSE) From English Into Kiswahili For Use In Kenya

There is a growing body of international research focusing on social factors and their impact on mental health of people living in developing countries. Because of the novelty of these studies and high cost associated with developing survey tools, researchers may choose to translate pre-existing survey tools instead. Research findings are only reliable if a translated instrument is equivalent in content, semantics, and concept to the original instrument. The objective of this study was to translate the Interpersonal Support Evaluation List (ISEL) and the Coping Self-Efficacy (CSE) from English into Kiswahili. The original version of each instrument was translated from English into Kiswahili (forward translation) and then the Kiswahili version was translated back into English (back-translation). The Kiswahili version was reviewed against the original version by a committee of experts. The committee corrected and modified the translated version to create the final Kiswahili version. The final versions were pre-tested by ten bilingual individuals living in New York to determine the instrument’s face-validity. The raters accepted the Kiswahili version as equivalent to the original English version. The Kiswahili versions were then administered to a sample of 212 people living with HIV in Kenya. Cronbach’s alpha reliability coefficients for the composite measures of ISEL and CSE were 0.905 and 0.860, respectively. The step-wise process of creating an equivalent translated version of a proven survey instrument may require adjustments specific to the cultural background of each target population of interest. Based upon the scientific rigor with which the translations took place, the authors support that both translated versions of the ISEL and CSE questionnaires are valid and reliable instruments to measure the social support and beliefs of Kiswahili-speaking people in Kenya

Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia

BACKGROUND Magnetic resonance-guided radiotherapy (MRgRT) utilization is rapidly expanding, driven by advanced capabilities including better soft tissue imaging, continuous intrafraction target visualization, automatic triggered beam delivery, and the availability of on-table adaptive replanning. Our objective was to describe patterns of 0.35 Tesla (T)-MRgRT utilization in Europe and Asia among early adopters of this novel technology. METHODS Anonymized administrative data from all 0.35T-MRgRT treatment systems in Europe and Asia were extracted for patients who completed treatment from 2015 to 2020. Detailed treatment information was analyzed for all MR-linear accelerators (linac) and -cobalt systems. RESULTS From 2015 through the end of 2020, there were 5796 completed treatment courses delivered in 46,389 individual fractions. 23.5% of fractions were adapted. Ultra-hypofractionated (UHfx) dose schedules (1-5 fractions) were delivered for 63.5% of courses, with 57.8% of UHfx fractions adapted on-table. The most commonly treated tumor types were prostate (23.5%), liver (14.5%), lung (12.3%), pancreas (11.2%), and breast (8.0%), with increasing compound annual growth rates (CAGRs) in numbers of courses from 2015 through 2020 (pancreas: 157.1%; prostate: 120.9%; lung: 136.0%; liver: 134.2%). CONCLUSIONS This is the first comprehensive study reporting patterns of utilization among early adopters of a 0.35T-MRgRT system in Europe and Asia. Intrafraction MR image-guidance, advanced motion management, and increasing adoption of on-table adaptive RT have accelerated a transition to UHfx regimens. MRgRT has been predominantly used to treat tumors in the upper abdomen, pelvis and lungs, and increasingly with adaptive replanning, which is a radical departure from legacy radiotherapy practices

The Organisms Living Around Energized Submarine Power Cables, Pipe, and Natural Sea Floor in the Inshore waters of Southern California

Between 1 February 2012 and 26 February 2014 using scuba, we surveyed the fishes, invertebrates, and macrophytes living on two energized submarine power cables, an adjacent pipe, and nearby natural habitat in southern California at bottom depths of 10–11 m and 13–14 m. Over the course of the study, average electromagnetic field (EMF) levels at the two cables (A and B) were statistically similar (Cable A = 73.0µT, Cable B = 91.4µT) and were much higher at these two cables than at either the pipe (average = 0.5µT) or sand (0µT). Overall, our study demonstrated that 1) the fish and invertebrate communities on cables, pipe, and natural habitat strongly overlapped and 2) there were differences between the shallower and deeper fish and invertebrate communities. We saw no evidence that fishes or invertebrates are either preferentially attracted to, or repelled by, the EMF emitted by the cables. Any differences in the fish or invertebrate densities between cables, pipe, and natural habitat taxa were most likely due to the differences in the physical characteristics of these habitats. As with the fishes and invertebrates, macrophytes did not appear to be responding to the EMF emitted by the cables. Rather, it is likely that differences in the plant communities were driven by site depth and habitat type

Performance of a repetitive task by aged rats leads to median neuropathy and spinal cord inflammation with associated sensorimotor declines

Epidemiological studies have demonstrated a relationship between advancing age and susceptibility to risk factors for median neuropathies and musculoskeletal disorders. In this study, we determined if performance of a voluntary reaching task by aged rats induced sensorimotor declines, median nerve dysfunction and increased inflammatory cytokines in peripheral nerves, muscle and spinal cord neurons. Aged (14 mon) rats were trained for 15 min/day for 4 weeks to learn a high repetition, low force (HRLF) task (19 reaches/min; 15% maximum pulling force). Aged task rats performed the task for 2 h/day, 3 days/wk, for 12 weeks (until they were 18 mon of age). No behavioral changes were detected in normal controls (NC) or food-restricted controls (FR C) as they aged. However, grip strength declined in HRLF rats in weeks 6-12 (P\u3c0.01 each) and 12-week trained-only rats (TR; P\u3c0.05), compared to NC. Mechanical hypersensitivity was present in weeks 9 and 12 HRLF reach limb forepaws (P\u3c0.01 and P\u3c0.05, respectively), and 12-week HRLF support limb forepaws (P\u3c0.01) and hindpaws (P=0.03), compared to NC. By week 12, median nerve conduction velocity declined 23%, bilaterally, in HRLF (P\u3c0.001 each), and 13% in TR (P\u3c0.05), compared to NC. Tumor necrosis factor alpha (TNFα) increased in 12-week HRLF muscle (P=0.005), median nerve (P\u3c0.01), and neurons in superficial lamina of HRLF cervical spinal cords (P\u3c0.01), compared to NC. interleukin 1 beta (IL1β) also increased in superficial lamina neurons (P\u3c0.01). Loss of grip strength was correlated with median nerve conduction slowing (r=0.70) as well as increased nerve and muscle TNFα (r=-0.38 and r=-0.41, respectively); decrease in forepaw withdrawal thresholds was correlated with median nerve conduction slowing (r=0.81), increased nerve TNFα (r=-0.59), and increased TNFα and IL1β in neurons in spinal cord dorsal horns (r=-0.52 and r=-0.47, respectively). Thus, aged rats performing a repetitive task exhibited sensorimotor declines that were associated with decreased median nerve conduction, and increased pro-inflammatory cytokines in the median nerve and cervical spinal cord neurons

The Iowa Homemaker vol.21, no.5

Candles Spread Christmas Cheer, Mary Ellen Sullivan, page 2 Milk Strengthens Defense, Betty Ann Iverson, page 3 American Wares Set Nation’s Tables, Ann Koebel, page 4 New World Harbours Refugees, Dorothy Ann Klein, page 5 Sally Anticipates a Gala Season, Mary Lou Springer, page 6 Applied Art Highlights, Lila Williamson, page 8 Bookmarks, Julie Wendel, page 9 What’s New in Home Economics, Dorothy Olson, page 10 For Holiday Shoppers, Betty Roth, page 12 Residence Halls Honor Women Leaders, Dorothy Gross, page 13 Express Ingenuity in Greetings, Doris Plagge, page 14 Alums in the News, Bette Simpson, page 15 Fruit Cakes for Holidays, Margaret Anne Clark, page 16 Across Alumnae Desks, Marjorie Thomas, page 18 Journalistic Spindles, Florence Byrnes, page 2

Carbon Nanofiber Incorporated Silica Based Aerogels with Di-Isocyanate Cross-Linking

Lightweight materials with excellent thermal insulating properties are highly sought after for a variety of aerospace and aeronautic applications. (1) Silica based aerogels with their high surface area and low relative densities are ideal for applications in extreme environments such as insulators for the Mars Rover battery. (2) However, the fragile nature of aerogel monoliths prevents their widespread use in more down to earth applications. We have shown that the fragile aerogel network can be cross-linked with a di-isocyanate via amine decorated surfaces to form a conformal coating. (3) This coating reinforces the neck regions between secondary silica particles and significantly strengthens the aerogels with only a small effect on density or porosity. Scheme 1 depicts the cross-linking reaction with the di-isocyanate and exhibits the stages that result in polymer cross-linked aerogel monoliths

Results of ASERTAA, a randomized prospective crossover pharmacogenetic study of immediate-release versus extended-release tacrolimus in African American kidney transplant recipients

BACKGROUND: Differences in tacrolimus dosing across ancestries is partly attributable to polymorphisms in CYP3A5 genes that encode tacrolimus-metabolizing cytochrome P450 3A5 enzymes. The CYP3A5*1 allele, preponderant in African Americans, is associated with rapid metabolism, subtherapeutic concentrations, and higher dose requirements for tacrolimus, all contributing to worse outcomes. Little is known about the relationship between CYP3A5 genotype and the tacrolimus pharmacokinetic area under the curve (AUC) profile in African Americans or whether pharmacogenetic differences exist between conventional twice-daily, rapidly absorbed, immediate-release tacrolimus (IR-Tac) and once-daily extended-release tacrolimus (LifeCycle Pharma Tac [LCPT]) with a delayed absorption profile. STUDY DESIGN: Randomized prospective crossover study. SETTING & PARTICIPANTS: 50 African American maintenance kidney recipients on stable IR-Tac dosing. INTERVENTION: Recipients were randomly assigned to continue IR-Tac on days 1 to 7 and then switch to LCPT on day 8 or receive LCPT on days 1 to 7 and then switch to IR-Tac on day 8. The LCPT dose was 85% of the IR-Tac total daily dose. OUTCOMES: Tacrolimus 24-hour AUC (AUC MEASUREMENTS: CYP3A5 genotype, 24-hour tacrolimus pharmacokinetic profiles. RESULTS: ∼80% of participants carried the CYP3A5*1 allele (CYP3A5 expressers). There were no significant differences in AUC LIMITATIONS: This was primarily a pharmacogenetic study rather than an efficacy study; the follow-up period was too short to capture clinical outcomes. CONCLUSIONS: Achieving therapeutic tacrolimus trough concentrations with IR-Tac in most African Americans results in significantly higher peak concentrations, potentially magnifying the risk for toxicity and adverse outcomes. This pharmacogenetic effect is attenuated by delayed tacrolimus absorption with LCPT. TRIAL REGISTRATION: Registered at ClinicalTrials.gov, with study number NCT01962922