Synergistic Signaling from Extracellular Matrix–Growth Factor Complexes

Investigations on extracellular matrix (ECM) and growth factor (GF) complexes have revealed an underappreciated phenomenon: they can either negate GF activity or generate synergistic signals for cell function, in particular mitogenesis. ECM and pericellular matrix molecules were first recognized to complex with GFs and regulate GF activity by the seminal observations that basic fibroblast growth factor (bFGF or FGF-2) required binding to a cell-surface heparin sulfate proteoglycan and to its authentic cell-surface receptor for biological activity (Klagsbrun and Baird, 1991; Yayon et al., 1991). Subsequently, numerous ECM–GF interactions that modulate GF activity were discovered; we have reviewed many of these findings (Macri et al., 2007)

Development of the Method for Calculation of Reinforced Concrete Structures on the Formation and Opening of Normal Cracks

This paper presents the history of the development of the method for calculating the crack resistance of reinforced concrete elements according to Soviet and modern design standards, which was based on the work of the Soviet and foreign scientists, such as: A.F. Loleit, V.I. Murashev, A.A. Gvozdev, S.A. Dmitriev, A. Clark, J. Monier and others. Also, the article discusses the currently updated calculation methods for the formation and opening of normal cracks according to domestic and foreign standards

Micro-meteoroid seismic uplift and regolith concentration on kilometric scale asteroids

Seismic shaking is an attractive mechanism to explain the destabilisation of regolith slopes and the regolith migration found on the surfaces of asteroids (Richardson et al. 2004; Miyamoto et al. 2007). Here, we use a continuum mechanics method to simulate the seismic wave propagation in an asteroid. Assuming that asteroids can be described by a cohesive core surrounded by a thin non-cohesive regolith layer, our numerical simulations of vibrations induced by micro-meteoroids suggest that the surface peak ground accelerations induced by micro-meteoroid impacts may have been previously under-estimated. Our lower bound estimate of vertical accelerations induced by seismic waves is about 50 times larger than previous estimates. It suggests that impact events triggering seismic activity are more frequent than previously assumed for asteroids in the kilometric and sub-kilometric size range. The regolith lofting is also estimated by a first order ballistic approximation. Vertical displacements are small, but lofting times are long compared to the duration of the seismic signals. The regolith movement has a non-linear dependence on the distance to the impact source which is induced by the type of seismic wave generating the first movement. The implications of regolith concentration in lows of surface acceleration potential are also discussed. We suggest that the resulting surface thermal inertia variations of small fast rotators may induce an increased sensitivity of these objects to the Yarkovsky effect.Comment: Accepted for publication in Icaru

Optomotor Swimming in Larval Zebrafish Is Driven by Global Whole-Field Visual Motion and Local Light-Dark Transitions

Stabilizing gaze and position within an environment constitutes an important task for the nervous system of many animals. The optomotor response (OMR) is a reflexive behavior, present across many species, in which animals move in the direction of perceived whole-field visual motion, therefore stabilizing themselves with respect to the visual environment. Although the OMR has been extensively used to probe visuomotor neuronal circuitry, the exact visual cues that elicit the behavior remain unidentified. In this study, we use larval zebrafish to identify spatio-temporal visual features that robustly elicit forward OMR swimming. These cues consist of a local, forward-moving, off edge together with on/off symmetric, similarly directed, global motion. Imaging experiments reveal neural units specifically activated by the forward-moving light-dark transition. We conclude that the OMR is driven not just by whole-field motion but by the interplay between global and local visual stimuli, where the latter exhibits a strong light-dark asymmetry

Identification of changes in hydrological drought characteristics from a multi-GCM driven ensemble constrained by observed discharge

Peer reviewedPublisher PD

Distortions of Experimental Muon Arrival Time Distributions of Extensive Air Showers by the Observation Conditions

Event-by-event measured arrival time distributions of Extensive Air Shower (EAS) muons are affected and distorted by various interrelated effects which originate from the time resolution of the timing detectors, from fluctuations of the reference time and the number (multiplicity) of detected muons spanning the arrival time distribution of the individual EAS events. The origin of these effects is discussed, and different correction procedures, which involve detailed simulations, are proposed and illustrated. The discussed distortions are relevant for relatively small observation distances (R < 200 m) from the EAS core. Their significance decreases with increasing observation distance and increasing primary energies. Local arrival time distributions which refer to the observed arrival time of the first local muon prove to be less sensitive to the mass of the primary. This feature points to the necessity of arrival time measurements with additional information on the curvature of the EAS disk.Comment: 10 pages, 6 figures, accepted for publication in Astroparticle Physic