Re-making the Hattersley

These artefacts are a site-specific investigation of the Old Weaving Shed (now demolished) at Sunnybank Mills, West Yorkshire (2014-2019). In embracing the space at Sunnybank Mills, Lane has used it as an opportunity for experimental re- interpretation, re-contextualisation and re-imagination. Research process: The artefacts explore the intersection between contemporary textile practice and the transient nature of derelict buildings and machines of the industrial north. Derelict buildings are deconstructed spaces in a state of entropic transformation and open to many interpretations. Through site specific reactivation of both space and artefacts, processes of making, un-making and re-making are explored. Lane casts, repaints and wraps remnant machine parts to re-engage the audience with the post-industrial form, questioning the object. Research insights: Exploring the post-industrial landscape, engaging directly with remnant objects, provides insight into the materiality of the space and what it contains. Making casts from found objects, re-positioning materials, weight, and wrapping a structure within the space engaged touch, repetition, time and reformed shape. This in turn has directed research towards newer questions of “what is?” “what exists?” and even “Is time a thing?” The latter expands on ideas of decay and entropy, not of time “taking its toll” but of simply one object or space moving to being another object or space (Rovelli, 2015). The object can be used by the audience to engage conversation and explore new narratives. Dissemination: The output was disseminated as follows: • By exhibition: ‘Make, Un-make, Re-make’, Sunnybank Mills, West Yorkshire (2017). • Through a conference paper: ‘Re-making the Derelict’, Textile and Place Conference at Manchester Metropolitan University, 2018. • Through conference proceedings: Soft pictures – Re-making the Hattersley, Futurescan 4: Valuing Practice, 2019

Soft Pictures – re-making the Hattersley

The exhibit ‘Soft Pictures – Re-making the Hattersley at Futurescan 4: Valuing Practice, University of Bolton, 23rd-24th January 2019, comprised a collection of created work based on a site-specific investigation of the derelict weaving shed at Sunnybank Mills, Farsley, Leeds, United Kingdom (UK), from 2014-present. Specifically, it focused on two old Hattersley looms which were left in the space. The work is a product of an exploration of thinking through practice. This has evolved around the relationship between my textile practice and the subject matter which pre-occupies it - the transient nature of the derelict (both building and machine). This is investigated through the prism of making, un-making and re-making, as a means of opening up a dialogue between textile and place. Derelict buildings are deconstructed spaces, in a state of entropic transformation and open to many interpretations. The investigation of this perception of change (or decline) through textile practice aims to unpick ideas of entropy and alterity and how this is interpreted. Time spent on the site progressed my initial documentary response of the ‘Soft Picture’ (Calderoni 2013) to a more active direct engagement with the space and machinery, resulting in the prolonged process of wrapping a loom. This was initially inspired by the work of Christo and Jeanne-Claude but rapidly became more about the meditative act of binding the machine. Further experiments around the machine entailed making casts of machine parts, as if cataloguing for a museum, and then taking the parts themselves and re-coating them in bright colours, re-making them into Meccano-like toys. All are active processes of making and re-making as a means of striking up a conversation with the un-making state of the site itself. The processes of making, unmaking and re-making have served to raise both physiological and philosophical questions for further exploration. The site is due for demolition in summer 2019 which will facilitate yet another journey of making investigations

Soft picture

The output is an artefact, a soft picture which is an embroidered wall piece, created as a documentary response to a derelict site, its space and the industrial Hattersley Loom within it. Research process: Lane embraced the post-industrial space at Sunnybank Mills as an opportunity for experimentation. The work relies on initial documentary photographic imagery, which is then digitally re-painted, printed onto cloth and embroidered. The resultant soft picture contains an image which is both tactile and visual at the same time and seeks to re-engage the audience with the pictorial re-imagining of industrial history from a contemporary perspective. Research insights: The work is a product of an exploration of thinking through practice. This has evolved around the relationship between textile practice and the subject matter which pre-occupies it – the transient nature of the derelict (both building and machine). This is investigated through a broader methodological prism of making, un-making and re-making, as a means of opening up a dialogue between textile and place. The soft, clean, crafted and domestically perceived medium of the embroidered textile runs counter to its hard, dirty, disordered and industrial subject and is raising questions about binary thinking, the either or and the other. Could the soft picture be used to open up debate around less binary and more inclusive thinking related to Michel Serres(2008) writings around ideas of ‘soft logic’? Dissemination: The output is disseminated as follows: • By exhibition: Make, Un-make, Re-make, Sunnybank Mills, West Yorkshire, 2017 • Through conference paper: Re-making the Derelict, Textile and Place Conference at Manchester Metropolitan University 2018 • Through conference proceedings: Soft pictures – Re-making the Hattersley,Futurescan 4: Valuing Practice 2019

'Recruitment, recruitment, recruitment' - the need for more focus on retention: a qualitative study of five trials

Abstract Background Loss to follow-up (attrition) is a frequent problem in clinical trials and can introduce bias or reduce power. So, understanding retention issues and strategies to address these are important. As part of a multi-method project, this qualitative study aimed to explore retention strategies used by trial teams and factors which may influence strategy adoption. Method A purposive sample of active trials was selected from the UK NIHR HTA portfolio of ongoing trials in 2014/2015. Semi-structured interviews with several trial team members from each trial and supplementary interviews with experienced trial managers explored strategies in collecting clinical outcome data and retaining participants. Interview data were analysed thematically using techniques of constant comparison. Results Twenty-two semi-structured interviews with trial team members including chief investigators, trial managers, nurses and research administrators revealed strategies used to enhance retention. Some were recognised methods and planned from trial outset whilst others were implemented more responsively. Interviewees placed great value on fostering positive relationships with trial participants to enhance retention. However, these strategies took time which was not always appreciated by the wider trial team or funding bodies. The national focus on recruitment targets in networks posed a challenge to staff and was deemed detrimental to retention. The ‘moral compass’ of individual researchers relied on their own beliefs and values and research experience and the factors affected their confidence to pursue participant data during follow-up. Conclusion The role of trial staff and their underlying behaviours influence retention practices and, combined with emphasis on recruitment targets, can be detrimental to motivation and retention activities. There is a need to consider how to train and support trial staff involved in retention practices and recognition of retention from funding bodies and oversight organisations

Generalised Compositional Theories and Diagrammatic Reasoning

This chapter provides an introduction to the use of diagrammatic language, or perhaps more accurately, diagrammatic calculus, in quantum information and quantum foundations. We illustrate the use of diagrammatic calculus in one particular case, namely the study of complementarity and non-locality, two fundamental concepts of quantum theory whose relationship we explore in later part of this chapter. The diagrammatic calculus that we are concerned with here is not merely an illustrative tool, but it has both (i) a conceptual physical backbone, which allows it to act as a foundation for diverse physical theories, and (ii) a genuine mathematical underpinning, permitting one to relate it to standard mathematical structures.Comment: To appear as a Springer book chapter chapter, edited by G. Chirabella, R. Spekken

Patient and public involvement in randomised clinical trials:a mixed-methods study of a clinical trials unit to identify good practice, barriers and facilitators

Abstract Background While patient and public involvement (PPI) in clinical trials is beneficial and mandated by some funders, formal guidance on how to implement PPI is limited and challenges have been reported. We aimed to investigate how PPI is approached within a UK Clinical Trials Unit (CTU)’s portfolio of randomised controlled trials, perceived barriers to/facilitators of its successful implementation, and perspectives on the CTU’s role in PPI. Methods A mixed-methods study design, involving (1) an online survey of 26 trial managers (TMs) and (2) Interviews with Trial Management Group members and public contributors from 8 case-study trials. Quantitative survey data were summarised using descriptive statistics and interview transcripts analysed thematically. Two public contributors advised throughout and are co-authors. Results (1) 21 TMs completed the survey; (2) 19 in-depth interviews were conducted with public contributors (n=8), TMs (n=5), chief investigators (n=3), PPI coordinators (n=2) and a researcher. 15/21 TMs surveyed reported that a public contributor was on the trial team, and 5 used another PPI method. 12/21 TMs reported that public contributors were paid (range £10–50/h). 5 TMs reported that training was provided for public contributors and few staff members had received any formal PPI training. The most commonly reported tasks undertaken by public contributors were the review of participant-facing materials/study documents and advising on recruitment/retention strategies. Public contributors wanted and valued feedback on changes made due to their input, but it was not always provided. Barriers to successful PPI included recruitment challenges, group dynamics, maintaining professional boundaries, negative attitudes to PPI amongst some researchers, a lack of continuity of trial staff, and the academic environment. Successful PPI required early and explicit planning, sharing of power and ownership of the trial with public contributors, building and maintaining relationships, and joint understanding and clarity about expectations/roles. CTUs have an important role to play in supporting recruitment, signposting and coordinating PPI. Conclusions While highly valuable, PPI in trials is currently variable. PPI representatives are recruited informally, may not be provided with any training and are paid inconsistently across trials. Study findings can help optimise PPI in trials and ensure researchers and public contributors are adequately supported

Demographic, clinical and laboratory differences between paediatric acute COVID-19 and PIMS-TS—results from a single centre study in the UK

BackgroundPaediatric symptomatic SARS-CoV-2 infections associate with two presentations, acute COVID-19 and paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Phenotypic comparisons, and reports on predictive markers for disease courses are sparse and preliminary.MethodsA chart review of COVID-19 and PIMS-TS patients (≤19 years) admitted to Alder Hey Children's NHS Foundation Trust, a tertiary centre in the North-West of England, was performed (02/2020–09/2022).ResultsA total of 161 symptomatic COVID-19 and 50 PIMS-TS patients were included. Peaks in admissions of patients with PIMS-TS occurred approximately 4 weeks after those for acute COVID-19. The incidence of in-patients with PIMS-TS reduced over time, and there were no admissions after February 2022. When compared to acute COVID-19, PIMS-TS patients were older (median: 10.3 years vs. 2.03 years; p < 0.001). There were no differences in gender distribution, but minority ethnicities were over-represented among PIMS-TS patients. Regional ethnic distribution was reflected among acute COVID-19 patients (66% vs. 84.5% White Caucasian, p = 0.01). Pre-existing comorbidities were more common among acute COVID-19 patients (54.7% vs. 8%, p < 0.001). PIMS-TS patients more commonly presented with abdominal symptoms (92% vs. 50.3%), neurological symptoms (28% vs. 10.6%) and skin rashes (72% vs. 16.8%), (p ≤ 0.01) when compared with acute COVID-19, where respiratory symptoms were more common (51.6% vs. 32%, p = 0.016). PIMS-TS more frequently required intensive care admission (64% vs. 16.8%), and inotropic support (64% vs. 9.3%) (all p < 0.05). More deaths occurred among acute COVID-19 patients [0 vs. 7 (4.4%)], with 5/7 (71%) in the context of pre-existing comorbidities. When compared to acute COVID-19, PIMS-TS patients exhibited more lymphopenia and thrombocytopenia, a more pronounced acute phase reaction, and more hyponatraemia (p < 0.05). Partial least square discriminant analysis of routine laboratory parameters allowed (incomplete) separation of patients at diagnosis, and variable importance projection (VIP) scoring revealed elevated CRP and low platelets as the most discriminatory parameters.ConclusionAdmissions for PIMS-TS reduced with increasing seroconversion rates in the region. Young age and pre-existing comorbidities associate with hospital admission for acute COVID-19. While PIMS-TS may present more acutely with increased need for intensive care, acute COVID-19 had an increased risk of mortality in this cohort

Demographic, clinical and laboratory differences between paediatric acute COVID-19 and PIMS-TS-results from a single centre study in the UK.

BackgroundPaediatric symptomatic SARS-CoV-2 infections associate with two presentations, acute COVID-19 and paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Phenotypic comparisons, and reports on predictive markers for disease courses are sparse and preliminary.MethodsA chart review of COVID-19 and PIMS-TS patients (≤19 years) admitted to Alder Hey Children's NHS Foundation Trust, a tertiary centre in the North-West of England, was performed (02/2020-09/2022).ResultsA total of 161 symptomatic COVID-19 and 50 PIMS-TS patients were included. Peaks in admissions of patients with PIMS-TS occurred approximately 4 weeks after those for acute COVID-19. The incidence of in-patients with PIMS-TS reduced over time, and there were no admissions after February 2022. When compared to acute COVID-19, PIMS-TS patients were older (median: 10.3 years vs. 2.03 years; p p = 0.01). Pre-existing comorbidities were more common among acute COVID-19 patients (54.7% vs. 8%, p p ≤ 0.01) when compared with acute COVID-19, where respiratory symptoms were more common (51.6% vs. 32%, p = 0.016). PIMS-TS more frequently required intensive care admission (64% vs. 16.8%), and inotropic support (64% vs. 9.3%) (all p p ConclusionAdmissions for PIMS-TS reduced with increasing seroconversion rates in the region. Young age and pre-existing comorbidities associate with hospital admission for acute COVID-19. While PIMS-TS may present more acutely with increased need for intensive care, acute COVID-19 had an increased risk of mortality in this cohort

Best-BRA (Is subpectoral or pre-pectoral implant placement best in immediate breast reconstruction?) A protocol for a pilot randomised controlled trial of subpectoral versus pre-pectoral immediate implant-based breast reconstruction in women following mastectomy

Background: implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure following mastectomy. IBBR techniques are evolving rapidly, with mesh-assisted subpectoral reconstruction becoming the standard of care and more recently, prepectoral techniques being introduced. These muscle-sparing techniques may reduce postoperative pain, avoid implant animation and improve cosmetic outcomes and have been widely adopted into practice. Although small observational studies have failed to demonstrate any differences in the clinical or patient-reported outcomes of prepectoral or subpectoral reconstruction, high-quality comparative evidence of clinical or cost-effectiveness is lacking. A well-designed, adequately powered randomised controlled trial (RCT) is needed to compare the techniques, but breast reconstruction RCTs are challenging. We, therefore, aim to undertake an external pilot RCT (Best-BRA) with an embedded QuinteT Recruitment Intervention (QRI) to determine the feasibility of undertaking a trial comparing prepectoral and subpectoral techniques.Methods and analysis: best-BRA is a pragmatic, two-arm, external pilot RCT with an embedded QRI and economic scoping for resource use. Women who require a mastectomy for either breast cancer or risk reduction, elect to have an IBBR and are considered suitable for both prepectoral and subpectoral reconstruction will be recruited and randomised 1:1 between the techniques.The QRI will be implemented in two phases: phase 1, in which sources of recruitment difficulties are rapidly investigated to inform the delivery in phase 2 of tailored interventions to optimise recruitment of patients.Primary outcomes will be (1) recruitment of patients, (2) adherence to trial allocation and (3) outcome completion rates. Outcomes will be reviewed at 12 months to determine the feasibility of a definitive trial.Ethics and dissemination: the study has been approved by the National Health Service (NHS) Wales REC 6 (20/WA/0338). Findings will be presented at conferences and in peer-reviewed journals.Trial registration number: ISRCTN10081873.</p