1 research outputs found
1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain
The
BRPF (bromodomain and PHD finger-containing) protein family are important
scaffolding proteins for assembly of MYST histone acetyltransferase
complexes. Here, we report the discovery, binding mode, and structure–activity
relationship (SAR) of the first potent, selective series of inhibitors
of the BRPF1 bromodomain