Structural parameters estimated from the rheological behavior of the collagen networks.

<p>Structural parameters estimated from the rheological behavior of the collagen networks.</p

Storage shear modulus(G’), lossmodulus(G”), dynamic viscosity (η’) and loss viscosity (η”) of collagen hydrogels with different composition after polymerization.

<p>Storage shear modulus(G’), lossmodulus(G”), dynamic viscosity (η’) and loss viscosity (η”) of collagen hydrogels with different composition after polymerization.</p

Storage shear modulus during polymerization of collagen hydrogels.

<p>Polymerization of five hydrogels with different collagen concentration without TG2 (left). Stress sweeps of five collagen hydrogels with different collagen concentration (right) after 24 hours of polymerization. Three independent specimens were analyzed for each hydrogel composition.</p

Storage shear modulus of collagen hydrogels with varying collagen concentration after polymerization, with and without TG2.

<p>Storage shear modulus of collagen hydrogels with varying collagen concentration after polymerization, with and without TG2.</p

Maximum shear strain before failure (%), maximum G’ during the stress sweeps and strain at the maximum G’.

<p>Maximum shear strain before failure (%), maximum G’ during the stress sweeps and strain at the maximum G’.</p

Experiment scheme.

<p>a) Scheme of the hydrogel in the rheometer in the experiment. b) Equivalent geometry used in the computational simulations in the undeformed state (b1) and after loading (b2).</p

Computational predictions.

<p>Experimental measurements and computational predictions of G'(Pa) for 1.5, 2, 2.5, 4 and 6 mg/ml hydrogels without transglutaminase (left) and for 2.5, 4, 6 mg/ml hydrogels with transglutaminase (right). Experimental results are showed by symbols and computational predictions are denoted by continuous lines.</p

Effect of transglutaminase on the storage shear modulus.

<p>Average shear modulus during polymerization of 2.5, 4 and 6 mg/ml collagen hydrogels w/o transglutaminase (left). Evolution of G’ during stress sweeps of the same hydrogels (right). Three independent specimens were analyzed for each hydrogel composition.</p

Normalized cell stress () distributions created by different laws [21], [25], [26] and the proposed model at the beginning of wound contraction.

<p>The wound has a radius of 0.5 cm. Every law produces a similar stress distribution despite dependence on different variables.</p

List of model parameters related to fibroblasts and myofibroblasts kinetics.

<p> Adjusted to fit reported migration rate with a traveling wave model.</p