Meta-analysis association results for hemoglobin in unconditional and conditional analyses in the <i>ABO</i> locus.

<p>Regional plots show (A) unconditional analysis and analysis conditional on (B) O, (C) AO, (D) AA, (E) B and (F) AB blood group haplotype. The most significant SNP in the unconditional analysis, rs507666, is highlighted throughout to facilitate comparison of results. The color coding of the LD between the SNPs ranges from dark blue for r² = 0–0.2 to red for r² = 0.8–1, and is grey where LD information was not available. Blue line represents suggestive and red line significant threshold.</p

Results of meta-analysis and replication analysis for 15 most significant SNPs in the <i>ABO</i> locus.

<p>Results of meta-analysis and replication analysis for 15 most significant SNPs in the <i>ABO</i> locus.</p

Blood groups derived based on three SNP haplotypes.

<p>Blood groups derived based on three SNP haplotypes.</p

Study characteristics.

<p>Study characteristics.</p

Manhattan plots of meta-analysis association results in unconditional and conditional analyses for hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC).

<p>Results show unconditional analysis for all three traits (top row) and analysis of Hb conditional on (A) Hct and (B) RCC, of Hct conditional on (C) Hb and (D) RCC and of RCC conditional on (E) Hb and (F) Hct. Line at–log₁₀(<i>P</i> value) = 5.3 represents suggestive threshold and line at–log₁₀(<i>P</i> value) = 7.3 significant threshold.</p

One-way analysis of variance in hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC) between different blood groups, as derived based on three SNP haplotypes.

<p>One-way analysis of variance in hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC) between different blood groups, as derived based on three SNP haplotypes.</p

Comparison of the effect sizes on 15 <i>ABO</i> SNPs between eight different traits.

<p>Traits include von Willebrand factor (log transformed, logVWF) and factor VIII (FVIII) for coagulation factors, total cholesterol (TC) and low-density lipoprotein (LDL) for lipids, hemoglobin (Hb), red blood cell count (RCC) and hematocrit (Hct) for the red blood cell (RBC) traits and alkaline phosphatase (log transformed, logALP) for liver marker group. The colored bar for each SNP represents the 95% confidence interval of the effect size.</p

Manhattan plot of HbA1c associated variants.

<p>Manhattan plot of the transethnic meta-analysis results in MANTRA. The dashed grey line indicates log₁₀BF = 6. Grey and green points denote known/novel loci, respectively. The lead HbA1c-associated variants identified through the ancestry-specific/transethnic analyses are circled in purple (the <i>G6PD</i> variant was not included in the MANTRA analysis, but the locus on the X-chromosome is indicated in the figure). Lines joining the plot & SNP number denote known loci (black), novel loci (green), and loci with a secondary distinct signal (red). MANTRA, Meta-Analysis of Transethnic Association.</p

T2D prediction, glycemic genetic score.

<p>Forest plot of association between glycemic genetic score with incident T2D over a decade-long follow-up period, by ancestry. MESA (European and Asian ancestry) and the <i>G6PD</i> variant (rs1050828) in ARIC (European and African American) were not included in the discovery GWAS analysis. Effect estimates were combined in a fixed effects meta-analysis. Overall effect estimate: 1.05, 95% CI 1.04–1.06, <i>p</i> = 2.5 × 10⁻²⁹. ARIC, Atherosclerosis Risk in Communities Study; ES, Effect Size; FHS, Framingham Heart Study; GWAS, genome-wide association study; G6PD, glucose-6-phosphate dehydrogenase; I-Squared, Higgin's I-squared statistic, a measure of heterogeneity; MESA, Multiethnic Study of Atherosclerosis; SCHS, Singapore Chinese Health Study; T2D, type 2 diabetes.</p

Reclassification of individuals with discordant T2D status based on prevailing diagnostic thresholds for FG and HbA1c before and after accounting for the effect of erythrocytic variants.

<p>Reclassification of individuals with discordant T2D status based on prevailing diagnostic thresholds for FG and HbA1c before and after accounting for the effect of erythrocytic variants.</p