Epigenetic regulation of tumor suppressors in t(8:21)-containing AML.

Item does not contain fulltextThe t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint

Transaction-based office price indexes: A spatiotemporal modeling approach

10.1111/j.1080-8620.2004.00093.xReal Estate Economics322297-32