Tracking of Energy Performance Indicators in Residential Building Stocks – Different Approaches and Common Results - EPISCOPE Synthesis Report No. 4

A central task of IEE EPISCOPE project was to carry out energy balance calculations and scenario analysis for national, regional or local residential building stocks against the background of energy saving and climate protection targets. The EPISCOPE Synthesis Report No. 4 documents the individual approaches of collecting information for the investigated residential building stocks as a foundation for building stock models and scenario calculations. Issues related to the availability of data and data quality are discussed, and concepts for a continuous monitoring (a regular data collection) are presented as a basis for a future tracking of energy performance in the observed building stocks

Voyage au bout de la suie. Chroniques des occupations humaines à la Grotte Mandrin

version française sous-titrée anglais/ french version subtitled in englishAnimated movie presented for the exhibition "The third Man, Prehistory of the Altaï" at the National Museum of Prehistory, 1/07/2017-13/11/2017.Exhibition commissariat : Jean-Jacques Cleyet-Merle and Mikael V. Shunkov./ written by : Ségolène Vandevelde/ directed by : Claire Dupuis/ on the basis of the research carried out on the parietal concretions of the Grotte Mandrin site by : Ségolène Vandevelde, Jacques É. Brochier, Christophe Petit et Ludovic Slimak/ contributions of : Benjamin Lambert (GL Conception)/ music and sound : Jean-Pierre Auger (Atelier Spectacle - Utopus)Animation vidéo présentée lors de l'exposition "Le troisième Homme, Préhistoire de l'AltaÏ" au Musée National de Préhistoire entre le 1er juillet 2017 et le 13 novembre 2017. Commissariat d'exposition : Jean-Jacques Cleyet-Merle et Mikael V. Shunkov./ écrit par : Ségolène Vandevelde/ réalisé par : Claire Dupuis/ à partir des recherches réalisées sur les concrétions pariétales de la Grotte Mandrin (Drôme, France) par : Ségolène Vandevelde, Jacques É. Brochier, Christophe Petit et Ludovic Slimak/ contributions de : Benjamin Lambert (GL Conception)/ musique et son : Jean-Pierre Auger (Atelier Spectacle - Utopus

Translocator Protein (18 kDa) Mapping with [I]-CLINDE in the Quinolinic Acid Rat Model of Excitotoxicity: A Longitudinal Comparison with Microglial Activation, Astrogliosis, and Neuronal Death

Excitotoxicity leads to an inflammatory reaction involving an overexpression of: translocator protein 18 kDa (TSPO) in cerebral microglia and astrocytes. Therefore, we performed ex vivo explorations with [ 125 ]-CLINDE, a TSPO-specific radioligand, to follow the time course of TSPO expression, in parallel with lesion progression, over 90 days after induction of cerebral excitotoxicity in rats intrastriatally injected with quinolinic acid. Biodistribution data showed a significant increase in CLINDE uptake on the injured side from 1 days postlesion (dpl); the maximal striatal binding values evidenced a plateau between 7 and 30 dpl. [ 125 I]-CLINDE binding was displaced from the lesion by PK11195, suggesting TSPO specificity. These results were confirmed by ex vivo autoradiography. Combined immunohistochemical studies showed a marked increase in microglial expression in the lesion, peaking at 14 dpl, and astrocytic reactivity enhanced at 7 and 14 dpl, whereas a prominent neuronal cell loss was observed. At 90 dpl, CLINDE binding and immunoreactivity targeting activated microglia, astrogliosis, and neuronal cell density returned to a basal level. These results show that both neuroinflammation and neuronal loss profiles occurred concomitantly and appeared to be transitory processes. These findings provide the possibility of a therapeutic temporal window to compare the differential effects of antiinflammatory treatments in slowing down neurodegeneration in this rodent model, with potential applications to humans

Translocator Protein (18 kDa) Mapping with [ 125

Excitotoxicity leads to an inflammatory reaction involving an overexpression of: translocator protein 18 kDa (TSPO) in cerebral microglia and astrocytes. Therefore, we performed ex vivo explorations with [ 125 ]-CLINDE, a TSPO-specific radioligand, to follow the time course of TSPO expression, in parallel with lesion progression, over 90 days after induction of cerebral excitotoxicity in rats intrastriatally injected with quinolinic acid. Biodistribution data showed a significant increase in CLINDE uptake on the injured side from 1 days postlesion (dpl); the maximal striatal binding values evidenced a plateau between 7 and 30 dpl. [ 125 I]-CLINDE binding was displaced from the lesion by PK11195, suggesting TSPO specificity. These results were confirmed by ex vivo autoradiography. Combined immunohistochemical studies showed a marked increase in microglial expression in the lesion, peaking at 14 dpl, and astrocytic reactivity enhanced at 7 and 14 dpl, whereas a prominent neuronal cell loss was observed. At 90 dpl, CLINDE binding and immunoreactivity targeting activated microglia, astrogliosis, and neuronal cell density returned to a basal level. These results show that both neuroinflammation and neuronal loss profiles occurred concomitantly and appeared to be transitory processes. These findings provide the possibility of a therapeutic temporal window to compare the differential effects of antiinflammatory treatments in slowing down neurodegeneration in this rodent model, with potential applications to humans