What research we no longer need in neurodegenerative disease at the end of life : The case of research in dementia

A complete silence. That was what we got back from the European experts who had been energetically discussing research priorities in palliative care in neurodegenerative disease (ND) until a short while ago.1 The chair, an entertaining professor with good manners, must have felt the unease and quickly refocused the group to their task. But, wasn’t this the best question of all day? What research we no longer need? As scientists able to consider different perspectives, shouldn’t we have some idea of what research is, by contrast, no longer necessary? Palliative care research and research with people who have ND and are at the end of their life is, by definition, difficult. Making choices is a sensitive issue, but funds are limited. Therefore, we take a counterpoint to the research agenda recently reported by European Union (EU) Joint Programme – Neurodegenerative Disease Research (JPND),1 and consider whether there are studies we no longer need or are low priority, taking the example of dementiaPeer reviewedFinal Accepted Versio

Exercises to develop the ability to classify words and to outline paragraphs grade IV.

Thesis (Ed.M.)--Boston Universit

Defining Landscape Resistance Values in Least-Cost Connectivity Models for the Invasive Grey Squirrel: A Comparison of Approaches Using Expert-Opinion and Habitat Suitability Modelling

Least-cost models are widely used to study the functional connectivity of habitat within a varied landscape matrix. A critical step in the process is identifying resistance values for each land cover based upon the facilitating or impeding impact on species movement. Ideally resistance values would be parameterised with empirical data, but due to a shortage of such information, expert-opinion is often used. However, the use of expert-opinion is seen as subjective, human-centric and unreliable. This study derived resistance values from grey squirrel habitat suitability models (HSM) in order to compare the utility and validity of this approach with more traditional, expert-led methods. Models were built and tested with MaxEnt, using squirrel presence records and a categorical land cover map for Cumbria, UK. Predictions on the likelihood of squirrel occurrence within each land cover type were inverted, providing resistance values which were used to parameterise a leastcost model. The resulting habitat networks were measured and compared to those derived from a least-cost model built with previously collated information from experts. The expert-derived and HSM-inferred least-cost networks differ in precision. The HSM-informed networks were smaller and more fragmented because of the higher resistance values attributed to most habitats. These results are discussed in relation to the applicability of both approaches for conservation and management objectives, providing guidance to researchers and practitioners attempting to apply and interpret a leastcost approach to mapping ecological networks.This project was funded by the Forestry Commission GB and the National School of Forestry at the University of Cumbria. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Worst Case Scenario and Stakeholder Group Decision: A 5-6 Meter Sea Level Rise in the Rhone Delta, France

Risk policy and public attitudes appear disconnected from research predicting warmer climate partially due to human activity. To step out of this stalled situation, a worst case scenario of a 5-6m sea level rise (SLR) induced by the collapse of the WAIS and occurring during the period 2030-2130 is constructed and applied to the Rhone delta. Physical and socio-economic scenarios developed with data from the Rhone delta context are developed and submitted to stakeholders for a day-long workshop. Group process analysis shows a high level of trust and cooperation mobilized to face the 5-6m SLR issue, despite potentially diverging interests. Two sets of recommendations stem from the scenario workshop. A conservative "wait and see" option is decided when the risk of the WAIS collapse is announced in 2030. After WAIS collapse generates an effective 1m SLR rise by 2050, decisions are taken for total retreat and rendering of the Rhone delta to its hydrological function. The transposition of these results into present times policy decisions could be considered. The methodology developed here could be applied to other risk objects and situations, and serve for policy exercises and crisis prevention.Sea level rise, France, Camargue, scenario, extreme climate, stakeholder workshop

“Waiting for Godot”- Restructuring on Small Family Farms

This paper examines the extent to which favourable off-farm labour market conditions coupled with growth in land values have contributed to the observed resilience of small scale family farms. We use data from Northern Ireland and employ farm household optimisation models to analyse household decision making processes that contribute to the observed inertia in farm structure. The analysis indicates that farm household behaviour is influenced not just by current farm income, but also expected capital asset returns. Increased wealth, associated with continuing land ownership, gives rise to the proposition that the link between off-farm incomes, increased land values and remaining in farming may be associated with farmers pursuing wealth maximizing objectives, whilst still maintaining a rural way of life. Alongside increased wealth through land ownership the farm household model quantifies the importance of off-farm income removing the pressure from farming income to fund all family consumption needs. This enables households to sustain low-income farming activities in order to pursue other objectives such as wealth management (including tax efficient transfer of wealth) and lifestyle. Consequently, the results indicate that the survival of small-scale family farms may be much less sensitive to agricultural support policies than has been commonly suggested. In an extension that explores the effects of the recent economic turbulence due to the ‘credit crunch’ we find that the households remain resilient even when subjected to a protracted period of reduced off-farm employment.Farm households, resilience, wealth accumulation, off-farm income, Consumer/Household Economics, Productivity Analysis, C61, Q12,

The status of secretarial science in 50 selected teacher-education institutions

Thesis (M.A.)--Boston University, 1947. This item was digitized by the Internet Archive