5 research outputs found
Electrocortical Responses to ecologically relevant visual stimuli among professional drivers with and without cardiovascular disease
- Author
- A. Goodman Gilman
- A. Steptoe
- Arne Wennberg
- B. Netterstrøm
- C. M. Yee
- C.F.A. KĂĽgler
- Cedo Savic
- D. Michaels
- D. S. Goodin
- G. Pfurtscheller
- J. Zubin
- J.D. Kropotov
- J.E. Skinner
- K. Barrett
- K. Belkić
- K. Belkić
- K. Belkić
- Karen Belkić
- Lotta Johansson
- M.A. Winkleby
- Maud Hagman
- P. Ullsperger
- R. Cooper
- R. Fuller
- R.S. Eliot
- Reza Emdad
- Stella Cizinsky
- T.C. Gunter
- T.W. Picton
- Töres Theorell
- W. Ritter
- W. Winsum Van
- W.C. McCallum
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evolocumab and clinical outcomes in patients with cardiovascular disease
- Author
- Abelson M.
- Aboufakher R.
- Abrahamsen T. E.
- Accini Mendoza J. L.
- Acheatel R.
- Ackermann D.
- Adamkova V.
- Adams M.
- Adlam D.
- Aggarwal R.
- Aggarwal S.
- Ahsan A.
- Ainsworth P.
- Airody Govinda R.
- Akai A.
- Ako J.
- Al-Bahrani A.
- Al-Joundi T.
- Aldegather J.
- Aldrete Velasco J. A.
- Alfieri A.
- Alt I.
- Alzohaili O.
- Amerena J.
- Amin J.
- Amoedo R.
- Amuchastegui M.
- Anderson T.
- Andreka P.
- Andreotti F.
- Angoulvant D.
- Ansell B.
- Antalik L.
- Antkowiak-Piatyszek K.
- Appel K.
- Arakawa T.
- Arana Londoño C.
- Ardissino D.
- Ardito W. R.
- Arkhipov M.
- Arsenescu-Georgescu C.
- Asamoah N.
- Ascaso Gimilio J. F.
- Atar S.
- Atassi K.
- Athyros V.
- Auerbach E.
- Awtry E.
- Baass A.
- Badariene J.
- Badat A.
- Badila E.
- Bae J.
- Baigent C.
- Bain S.
- Baird I.
- Baker J.
- Balbay Y.
- Baldari D.
- Ballantyne C.
- Bammert A.
- Banach M.
- Bandh S.
- Banerjee S.
- Banik M.
- Banikova A.
- Barbarash O.
- Barcinas R.
- Barnum O.
- Barroso de Souza W. K.
- Bart B.
- Barton J.
- Bata I.
- Batalla E.
- Bayat J.
- Bazzoni Ruiz A. E.
- Bednarkiewicz Z.
- Beer H. J.
- Begg A.
- Beltrame J.
- Bendermacher P.
- Benton R.
- Berger C.
- Bergeron J.
- Bergler-Klein J.
- Berglund S.
- Berlacher P.
- Bernstein M.
- Bertolet B.
- Bertolim Precoma D.
- Bhagwat R.
- Bhargava R.
- Bhushan R.
- Biasucci L. M.
- Bilianou H.
- Blagden M.
- Blaha V.
- Blasko P.
- Blicharski T.
- Blignaut S.
- Blokhin A.
- Blumberg E.
- Bodanese L. C.
- Bokern M.
- Bolshakova O.
- Bonaca M. P.
- Bonnet B.
- Bosiljanoff P.
- Boswijk D.
- Botero Lopez R.
- Bourhaial H.
- Bousboulas S.
- Brabec T.
- Brezina B.
- Bronnum-Schou J.
- Brotanek J.
- Broughton R.
- Brown C.
- Brown W. V.
- Bubnova M.
- Budoff M.
- Burgess L.
- Burianova H.
- Burrough B.
- Butler R.
- Buysschaert I.
- Bystryk L.
- Capps N.
- Cappuccio F.
- Cardona Muñoz E. G.
- Carhart R.
- Cariou B.
- Carr K.
- Case C.
- Castellanos Bueno R.
- Catez E.
- Caulfield M.
- Cayla G.
- Cech V.
- Cepelak M.
- Ceska R.
- Cha J.
- Chandra L.
- Chapman K.
- Charlier F.
- Charng M. J.
- Charvat J.
- Chauhan A.
- Cheek H. B.
- Chehayeb R.
- Chen J.
- Chen X.
- Chen Yu
- Chenu P.
- Cheung D.
- Cho Y.
- Choi D.
- Chopra V. K.
- Chorin E.
- Christensen T.
- Christofides E.
- Cifkova R.
- Civeira Murillo F.
- Cizinsky S.
- Clardy D.
- Claxton E.
- Clements B.
- Cobos J. L.
- Coching R. M.
- Coetzer T. F.
- Coisne D.
- Collins J.
- Colombo H.
- Coman I.
- Conejeros Kindel C.
- Connolly D.
- Constance C.
- Contzen C.
- Cordero Fort A.
- Cornel J. H.
- Coronel Arroyo J. A.
- Cosmi F.
- Cottin Y.
- Cox N.
- Crater T.
- Crean P.
- Croce K.
- Cross D.
- Crowley D.
- Cruickshank K.
- Cuadrado J. A.
- Cui H.
- Cui Y.
- Cummings M.
- Cuneo C.
- Cunha Borges J. L.
- Cure Cure C. A.
- Cygler J.
- Dabrowska M.
- Dabrowski M.
- Dahlén G.
- Dai H.
- Dan G. A.
- Danias P.
- Darius H.
- Dauber I.
- Dave K.
- Davila W.
- Davis B. R.
- Davis G.
- Davis M.
- Dawood S.
- de Belder M.
- De Caterina R.
- De Ferrari G. M.
- De Jong D. M.
- De La Cruz A.
- De la Peña Topete G. D. J.
- De los Rios Ibarra M. O.
- De Meulemeester M.
- De Nooijer C.
- De Raedt H.
- de Sa Cunha R.
- De Souza J.
- Dear H.
- Deedwania P. C.
- Delarche N.
- Delgado E.
- Demir M.
- Den Hartog F.
- Derian W.
- Desai A.
- Descamps O.
- Desire A.
- Dill S.
- Diogo J.
- Dixon L.
- Dobkin L.
- Dobratz D.
- Donnelly P.
- Douglas F.
- Dowell A.
- Doyle T.
- Dronov D.
- du Toit M.
- Du Y.
- Duarte Barbosa E. C.
- Dubaniewicz W.
- Duchesne L.
- Dunaj M.
- Dunbar R.
- Durlach V.
- Dutra O.
- Duzenli M.
- Dwivedi S. K.
- Dyke C.
- Dzupina A.
- Earl J.
- Eaton C.
- Ebenbichler C.
- Eberli F.
- Ebrahim I.
- Edes I.
- Eglite R.
- Egstrup K.
- El Shahawy M.
- Elam M.
- Elbl L.
- Eliaschewitz F. G.
- Elisaf M.
- Ellery A.
- Engel E.
- Engelbrecht J.
- Ercan E.
- Erglis A.
- Erickson B.
- Erng T.
- Estepar R. A.
- Ezhov M. V.
- Fagan T.
- Fairlie H.
- Falck G.
- Fan K. Y. Y.
- Farhat N.
- Farris N.
- Farshid A.
- Fedele F.
- Fernandes Manenti E. R.
- Fernandez S.
- Ferrari E.
- Ferreira Rossi P. R.
- Ferreira J.
- Ferri C.
- Ferrieres J.
- Fialkow J.
- Filipová S.
- Finlayson J.
- Fiore G.
- Fischer M.
- Fiserova N.
- Fish M. P.
- Fishbein G.
- Fisher M.
- Floresta A. M.
- Focil A.
- Forgosh L.
- Fortuin F.
- Fotherby K.
- Fox C.
- Frana P.
- Fredrick M.
- Freidlin M.
- French J.
- Friart A.
- Fritz R.
- Fujino Y.
- Fujita H.
- Fulop P.
- Funazaki T.
- Gabra N.
- Gaciong Z. A.
- Gan H. W.
- Gandy W.
- Gao X.
- Garbocz P.
- Garrahy P.
- Gaudet D.
- Gaunt R.
- Gavish D.
- Ge Z.
- Geadah C.
- Gelfand E.
- Georgiev B. G.
- Germar A.
- Ghali J.
- Gilpatrick M.
- Giugliano G.
- Giugliano R. P.
- Glenny J. A.
- Go A.
- Go Y.
- Goel A.
- Goldenberg E.
- Goloshchekin B.
- Golovchenko O.
- Gonnelli S.
- Gonsorcik J.
- Gonzalez Juanatey J. R.
- Gonzalez-Galvez G.
- Goralski M.
- Gordeev I.
- Gorog D.
- Gossard D.
- Gosselin G.
- Gotchev D.
- Gouni-Berthold I.
- Graham J.
- Greenwald J.
- Griffin S.
- Groutars R.
- Grubb S.
- Gruberg L.
- Grzegorzewski B.
- Gu Y.
- Gupta D.
- Gupta M.
- Gustiene O.
- Guyton J.
- Guzik T.
- Gyrina O.
- Habaluyas R.
- Hack T.
- Haddad T.
- Hage Korban E.
- Hajko E.
- Hala T.
- Hall A.
- Halperin F.
- Hamet P.
- Hammett C.
- Hamroff G.
- Han K. H.
- Handelsman Y.
- Hanefeld M.
- Hanlon K.
- Hanusch U.
- Hare P. O.
- Harris M.
- Hart R.
- Hartleib M.
- Harvey J.
- Hasbani E. G.
- Hasin Y.
- Hata Y.
- Hatalova K.
- Hatharasinghe R.
- Haught W. H.
- He Y.
- Hearne S.
- Heller S.
- Henderson D.
- Henein S.
- Hengstenberg C.
- Hennekens C. H.
- Henry Bruno
- Henry P.
- Her S.
- Herczeg B.
- Herman L.
- Hermany P.
- Hernandez Triana E.
- Herrman J.
- Hersbach F.
- Hershon K.
- Hershson A.
- Herzog W.
- Hess A.
- Hetzel G.
- Hiczkiewicz J.
- Higa N.
- Higashi Y.
- Himeno H.
- Hirayama A.
- Hissa M.
- Hitchcock J.
- Ho C.
- Hoffer E.
- Hoivik H. O.
- Holder S.
- Homza M.
- Honarpour N.
- Hong B.
- Hornyik A.
- Horrigan M.
- Hosokawa S.
- Hove J.
- Hovland A.
- Hoye A.
- Hrabar A.
- Hranai M.
- Hsia C.
- Hsieh I.
- Hsieh Y.
- Huang C.
- Huang H.
- Huang W.
- Huber K.
- Huling R.
- Hulinsky V.
- Huynh T.
- Hysing J.
- Ibrahim Hassan
- Iida H.
- Ilkowski J.
- Illescas Diaz J. J.
- Im K.
- Inage T.
- Inoko M.
- Isermann B.
- Issa B.
- Issa M.
- Isserman S.
- Iteld B.
- Ivan P.
- Iwade K.
- Izar M. C.
- Izumiya Y.
- Iñiguez Romo A.
- Jaafar F.
- Jackson R.
- Jacovides A.
- Jain A.
- Janik M.
- Jansen R.
- Janus C.
- Jardula M.
- Jasinkevica I.
- Jehle A.
- Jelinek P.
- Jelinek Z.
- Jeong M.
- Jeppesen J.
- Jerabek O.
- Jiang J.
- Jiang L.
- Jocson G.
- Joffe I.
- Johansson P.
- Johnston J.
- Joshi A.
- Juang J.
- Juergens C.
- Jukema J. W.
- Jupp B.
- Kadokami T.
- Kahri J.
- Kahrmann G.
- Kaigawa K.
- Kaik J.
- Kajiyama S.
- Kakurina N.
- Kanevsky E.
- Kania G.
- Kanno M.
- Kapp C.
- Karadi I.
- Karakas M.
- Karalis I.
- Karen I.
- Karpenko O.
- Kashyap M.
- Kassner U.
- Kast P.
- Katsuda Y.
- Kawabata K.
- Kawamitsu K.
- Kawasaki T.
- Kayikcioglu L.
- Kazdera P.
- Keech A. C.
- Keeling P.
- Kellnerova I.
- Kereiakes D.
- Kerr Saraiva J. F.
- Khalife K.
- Khan A.
- Khan B.
- Khan M.
- Khandait V.
- Khanoyan P.
- Khurana S.
- Kim B.
- Kim M.
- Kim S.
- Kim W.
- Kinasz L.
- King M.
- Kingston D.
- Kinova E.
- Kirma C.
- Kirstein J.
- Kiss R.
- Kitova L.
- Kiyosue A.
- Kjaernli T.
- Kjaerulf Jensen H.
- Klausen I. C.
- Klimsa Z.
- Klug E.
- Klutstein M.
- Knusel B.
- Kobalava Z.
- Kochiadakis G.
- Koga Y.
- Kohli N.
- Koike A.
- Kok J.
- Koleckar P.
- Kolovou G.
- Kondagunta V.
- Konieczny M.
- Kooij A.
- Kopaczewski J.
- Kopytsya M.
- Koren M.
- Kork A.
- Korsgaard Thomsen K.
- Korzh O.
- Kosek Z.
- Kosior D.
- Kostenko V.
- Kostner K.
- Kothiwale V.
- Kovar F.
- Kozlowski L.
- Kozuma K.
- Kraatz U.
- Kracoff O.
- Kramarczuk E.
- Kraydashenko O.
- KraŃ–z I.
- Krejcova H.
- Krishna J.
- Kritharides L.
- Krupicka J.
- Kryza R.
- Krähenbühl S.
- Ksiezycka-Majczynska E.
- Kubica J.
- Kucera D.
- Kuchar J.
- Kuchar L.
- Kuchar R.
- Kucinskiene A.
- Kuder J. F.
- Kulkarni G.
- Kulynych O.
- Kurtz Lisboa H. R.
- Kurtz C.
- Kusiak D.
- Kusnick B.
- Kvasnicka J.
- Lader E.
- Ladyjanskaia G.
- Lagocki S.
- Lai W.
- Lakatos F.
- Lalmand J.
- Lanas Zanetti F.
- Landzberg J.
- LaRosa J.
- Laszlo Z.
- Lawless A.
- Lazov P.
- Le Corvoisier P.
- Leaes P. E.
- Lee C. Y.
- Lee D.
- Lee Sing-E
- Leeman D.
- Lehman S.
- Leitao A.
- Leiter L. A.
- Leiva Pons J. L.
- Lekuona Goya I.
- Lemos Agostinho
- Lennerova J.
- Leon de la Fuente R.
- Leon Gonzalez S.
- Lepich T.
- Levin P.
- Levinson D.
- Lewis B. S.
- Li D.
- Li J.
- Li W.
- Li X.
- Li Z.
- Lian Y.
- Liem A.
- Lieverse A.
- Liew H.
- Lighezan D.
- Lillo J.
- Lindholm C.
- Link M.
- Linka A.
- Linsky R.
- Linssen G.
- Linzmeyer K.
- Lip G.
- Lipschitz S.
- Lira Pineda A.
- Liu F.
- Liu T.
- Liu Y.
- Llamas Esperon G. A.
- Lo E.
- Loh I.
- Lok D.
- Lonn E.
- Lopez Alvarado A.
- Lopez Santi R. G.
- Lorenzatti A. J.
- Lottering H.
- Lowe C.
- Lozada A.
- Lubiszewska B.
- Ludka O.
- Luger A.
- Lukacova J.
- Lukyanov Y.
- Lupkovics G.
- Lutskiy M.
- Lymar I.
- Lynch M.
- Lysek R.
- LĂłpez-Miranda J.
- Mach F.
- Machkova M.
- Mackenzie I.
- Mackinnon I.
- Magro M.
- Mahajan A.
- Makam S.
- Makotoko E.
- Malecha J.
- Malone M.
- Malynovsky Y.
- Mandviwala M.
- Manolis A.
- Manolova A.
- Mansour S.
- Mantas I.
- Manzur Jattin F.
- Marais H.
- Marcucci R.
- Marcus A.
- Marenzi G.
- Marhefka G.
- Mariat C.
- Mark L.
- Markdanner Lindgren L.
- Markov V.
- Marten I.
- Maskon O.
- Mathew A.
- Matos P.
- Matsuo H.
- Matuska J.
- Maus O.
- Mays M.
- Mazur J.
- McAdam B.
- McCormack T.
- McCullum K.
- McDowell E.
- McElveen W.
- McGrew F.
- McIntyre H.
- McKinnon C.
- McLellan B.
- McNally D.
- McRae A.
- Meengs M.
- Mehta V.
- Melchior T.
- Melidonis A.
- Mendez Machado G. F.
- Mennuni M.
- Merkely B.
- Merlini P.
- Mertzanos G.
- Meshkov A.
- Michel Patrick
- Mickley H.
- Militaru C.
- Millan Nuñez-Cortes J.
- Miller A.
- Miller M.
- Mirek-Bryniarska E.
- Mitchell C.
- Mitu F.
- Mo Z.
- Moccetti T.
- Mohacsi A.
- Mohamed Yusof A. K.
- Mohammed A.
- Molina de Salazar D. I.
- Molter D.
- Monajemi H.
- Moncada Corredor M. A.
- Montalescot G.
- Monteiro P.
- Moodley R.
- Mooe T.
- Mooss A.
- Moretti L.
- Moriarty P.
- Morris P.
- Moschos N.
- Mosiewicz J.
- Motreff P.
- Motylev I.
- Moura Jorge J. C.
- Muderrisoglu I. H.
- Muir S.
- Mukherjee A.
- Murphy S. A.
- Murray J.
- Murthy D.
- Muzulu S.
- Myshanych G.
- MĂĽnzel T.
- Nadar V.
- Nagajothi N.
- Nagy A.
- Nagy K.
- Nakamura Y.
- Nakane H.
- Nakashima E.
- Nakhle S.
- Namba S.
- Napoli M.
- Napora P.
- Navarro J.
- Negahban A.
- Nemecek E.
- Nevarez Ruiz L. A.
- Newby D.
- Newcomer J. W.
- Nicolau J. C.
- Nicolosi L.
- Nicolson A.
- Nielsen H.
- Nielsen T.
- Nieminen S.
- Nigro F.
- Nilsson L.
- Noguchi Y.
- Norden A.
- Norheim P.
- Ntaios G.
- Nunohiro T.
- Nyman K.
- O'Donnell M.
- Ohmura H.
- Okada M.
- Okamoto H.
- Oku K.
- Oliveira L.
- Olsen S.
- Olsson A.
- Olsson S.
- Onyema D.
- Oomen A.
- Oosthuysen W. M.
- Opitz C.
- Ord J.
- Oriesek R.
- ORourke D.
- Osea E.
- Osipova I.
- Oude Ophuis A.
- Pacora F.
- Pai R.
- Paillard F.
- Panagoulis C.
- Pande A.
- Pandey A. S.
- Panov A.
- Papp A.
- Papp E.
- Parikh K.
- Parkhomenko O.
- Parmar M.
- Pasierski T.
- Pasquini J.
- Pastrnakova E.
- Patsilinakos S.
- Paul N.
- Paulweber B.
- Pearlstein P.
- Pedersen T. R.
- Pei H.
- Pella D.
- Peniston J.
- Penny W.
- Pentela-Nowicka J.
- Pereira H.
- Perez Alva J. C.
- Perna E.
- Perrone Filardi P.
- Pesant Y.
- Peterfai E.
- Peterka K.
- Peterson S.
- Petrella R.
- Petrov I.
- Pettersson S. I.
- Pharr W.
- Piepiorka M.
- Pierpont B.
- Piippo T.
- Pijanowski Z.
- Pillay S.
- Pimenov L.
- Pimentel Filho P.
- Pincetti Jofre C. P.
- Pintilei E.
- Pinto Sala X.
- Piros G. A.
- Pirro M.
- Podolec P.
- Podpera I.
- Pogue B.
- Poirier P.
- Pojsl S.
- Polasek R.
- Poock J.
- Popescu M. I.
- Pothineni R. B.
- Potthoff Cardenas S.
- Potu R.
- Pozdisek Z.
- Prager R.
- Prasan A.
- Pretorius M.
- Prokhorov O.
- Przekwas-Jaruchowska M.
- Pucheu Y.
- Purdy D.
- Purohit J.
- Pye M.
- Qu P.
- Quintero Baiz A. E.
- Rabinowitz A.
- Raczak G.
- Radzeviciene-Jurgute R.
- Raev D.
- Rahimi S.
- Raisinghani A.
- Rajadhyaksha G.
- Rallidis L.
- Ramanathan G. L.
- Rammer M.
- Ramos Lopez G. A.
- Ramos M.
- Ramstad D.
- Range G.
- Raoof T.
- Rapezzi C.
- Rasmanis G.
- Rebrov B.
- Rech R. L.
- Recknor C.
- Reddy J.
- Reichert P.
- Reichman A.
- Reis G.
- Remler R.
- Rensing B.
- Reschak M.
- Reshotko D.
- Reyes H.
- Rezkalla S.
- Rha S.
- Rice L.
- Richter D.
- Rider J.
- Rietzschel E.
- Rigler S.
- Rinke A.
- Risberg K.
- Rishko M.
- Roberts Thomson P.
- Robinson J.
- Rodriguez D.
- Roelandt R.
- Rogelio G. G.
- Rogers W.
- Rojas C. G.
- Roseman H.
- Rosenson R.
- Rosenthal A.
- Rosolova H.
- Rost N.
- Rothschild R.
- Roubille F.
- Rouzier R.
- Rowe W.
- Rubenfire M.
- Ruberg F.
- Rubino J.
- Rudenko L.
- Rudyk I.
- Runquist L.
- Rupka D.
- Rutherfurd S.
- Rychlewska-Hanczewska A.
- Rysava D.
- Römer T.
- Saaiman J.
- Saavedra Gajardo V. A.
- Sabatine M. S.
- Sabbah E.
- Sabe-Affaki G.
- Sacco J.
- Saetre Lihn A.
- Sahin T.
- Sakagami S.
- Sakhrani L.
- Saksena R.
- Saku K.
- Salamon C.
- Salbach P.
- Samal A.
- Sampietro T.
- Sanabria H. D.
- Sanchez Diaz C. J.
- Sanchez Vallejo G.
- Sanford K.
- Saravanan P.
- Sarkar D.
- Sarvan M.
- Sato K.
- Satoh Y.
- Savolainen M.
- Saway W.
- Scheen André
- Schenkenberger I.
- Schernthaner G.
- Schiele F.
- Schiff E.
- Schlau A.
- Schmedtje J.
- Schmidt E. B.
- Schnitzler R.
- Schooley C.
- Schramm E.
- Schreibman D.
- Schäufele T.
- Scott J.
- Scott R.
- Seaton B.
- Senior R.
- Senni M.
- Sepulveda Varela P. A.
- Sever P. S.
- Shah A.
- Shah M.
- Shalaev S.
- Shalek M.
- Shaoulian E.
- Shapiro M.
- Shatylo V.
- Shechter M.
- Shen X.
- Sherenkov A.
- Sherman H.
- Shifrin G.
- Shimizu M.
- Shin G. J.
- Shinozaki T.
- Shirasawa K.
- Shore K.
- Shotan A.
- Shustov S.
- Shutemova E.
- Shvarts Y.
- Sigurdsson A.
- Silverman S.
- Sime I.
- Simon W.
- Simons R.
- Simpson R.
- Singh I.
- Singhal A.
- Sinhal A.
- Sinzinger H.
- Siostrzonek P.
- Siu C. W.
- Siu S. C.
- Skonieczny G.
- Skoumas I.
- Skrobakova J.
- Snyder B.
- Soares Goncalves S.
- Soares Piegas L.
- Sochor K.
- Sofley C. W.
- Solanki B.
- Solnor L.
- Solovev O.
- Solovieva E.
- Somaratne R.
- Sorokina I.
- Sosovec D.
- Sotomayor Herazo A.
- Spaulding C.
- Spencer R.
- Spinar J.
- Spinarova L.
- Spriggs D.
- Spyra J.
- Srivastava S.
- St Amour E.
- Staneta P.
- Stania K.
- Stanislavchuk M.
- Stapelberg A.
- Stawowy P.
- Steiner S.
- Steinsapir J.
- Stephens L.
- Stockins Fernandez B. A.
- Stonesifer L.
- Stout E.
- Strand J.
- Strandberg T. E.
- Strazdiene V.
- Stringam S.
- Strobl D.
- Stukena I.
- Su H.
- Subramaniam T.
- Sugino H.
- Sun Y.
- Suomi J.
- Sussex B.
- Suutari A.
- Svishchenko Y.
- Sy R. A.
- Szakal I.
- Szpajer M.
- Szymkowiak K.
- Söderberg S.
- Tahirkheli N.
- Tami L.
- Tan J. L.
- Tanabe J.
- Tang A.
- Tang Y.
- Tanno H.
- Tarasov N.
- Tarleton G.
- Tarnovska-Kadreva R.
- Tavares Russo L. A.
- Tay L.
- Teodorescu I.
- Tereshenko S.
- Terront Lozano M. A.
- Teterovska D.
- Thoeng J.
- Thom S.
- Thomas H.
- Thompson C.
- Thompson P.
- Thomson S.
- Thorgeirsson G.
- Tie S.
- Tikkanen M. J.
- Timoteo A. T.
- Tobin T.
- Tokgozoglu S. L.
- Tokunaga T.
- Tomcsanyi J.
- Tonino W.
- Toplak H.
- Torres M.
- Toth K.
- Travill C.
- Trebacz J.
- Trendafilova-Lazarova D.
- Trenk D.
- Treshkur T.
- Trevelyan J.
- Troquay R.
- Tsai C. F.
- Tseluyko V.
- Tsoukas G.
- Tudoran M.
- Tyagi S.
- Tydén P.
- Tyszecka G.
- Tzekova M.
- Tziakas D.
- Uehara H.
- Uemura O.
- Ueno T.
- Uhliar R.
- Ulla M. R.
- Urbach D.
- Urgeova L.
- Vaclavik J.
- Vakaliuk I.
- Valdes Chavarri M.
- Vally T.
- Valter I.
- Van Beek E.
- van de Borne P.
- van de Wal R.
- van der Walt E.
- van der Zwaan C.
- Van Gaal W.
- Van Hessen M.
- Van Zyl L.
- VanBelle E.
- Vandekerckhove H.
- Vasco Salgado A.
- Vawda G.
- Velchev V.
- Venceviciene L.
- Venegas Carrillo L. A.
- Verheye S.
- Vertes G.
- Veze I.
- Vida Gutierrez M.
- Vidotti M. H.
- Viigimaa M.
- Vijay N.
- Vikman S.
- Vinanska D.
- Vintila M. M.
- Violante Ortiz R. M.
- Vishnevsky A.
- Visman A.
- Vita J.
- Voevoda M.
- Vogel D. R.
- Volkov V.
- Vomacka Z.
- von Hodenberg E.
- Vora K.
- Vorpahl M.
- Wada A.
- Wagner S.
- Wan Ahmad W. A.
- Wang D.
- Wang H.
- Wang J.
- Wasserman S. M.
- Waxman F.
- Webel R.
- Webster J.
- Weinberg B.
- Weinstein D.
- Welker J.
- Wermuth S.
- Westendorp I.
- Weyland K.
- Whitney R.
- Wierzbicka K.
- Wilhoit G.
- Wilson S.
- Wise J.
- Wiseman A.
- Witt N.
- Wittert G.
- Wiviott S. D.
- Wnetrzak-Michalska R.
- Wollaert B.
- Wood S. K.
- Wozakowska-Kaplon B.
- Wozniak I.
- Wu C.
- Wyatt N.
- Wöhrle J.
- Xu P.
- Xue L.
- Yakhontova P.
- Yamamoto K.
- Yamashita K.
- Yan J.
- Yang E.
- Yang P.
- Yang X.
- Yang Y.
- Yang Z.
- Yao Zhuhua
- Yasumura Y.
- Yataco A.
- Yeh H.
- Yena L.
- Yeoman G.
- Yigit Z.
- Yilmaz M. B.
- Yokoya K.
- Yoshimichi G.
- Yotov Y.
- Youngman D.
- Younis L.
- Yuge M.
- Zabowka M.
- Zahn L.
- Zamorano Gomez J. L.
- Zarich S.
- Zateyshchikov D.
- Zdrenghea D.
- Zechowicz T.
- Zeig S.
- Zemanek J.
- Zeng X.
- Zhang L.
- Zhang X.
- Zhao S.
- Zheng Y.
- Zheng Z.
- Zhou C.
- Zhu Y.
- Zhurba S.
- Zidkova E.
- Zieba B.
- Ziegler O.
- Zilahi Z.
- Zrazhevskiy K.
- Ă–stergren J.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
peer reviewedBACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%). CONCLUSIONS In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets. © 2017 Massachusetts Medical Society
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
- Alvarez Y
- Alves A
- Amidon T
- Amos M
- Anaszewicz M
- Andersen M
- Andersen O
- Andersson E
- Andersson G
- Andrade G
- Andrade M
- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
- Arana C
- Aranda M
- Araujo J
- Arce R
- Ardito RV
- Ardito W
- Arend C
- Arias V
- Armada E
- Armstrong P
- Arnold A
- Arnold M
- Arntsen BI
- Arora P
- Aros F
- Arriagada G
- Arriagada G
- Artaecheverria J
- Arvesen K
- Arvigo L
- Ash Y
- Aske R
- Ata N
- Atar D
- Atar S
- Atassi K
- Atieh M
- Atkinson C
- Atzenhofer-Baumgartner K
- Auer J
- Aug L
- Ausen K
- Aycock G
- Aylward P
- Aylward P
- Ayres T
- Azize G
- Azrin M
- Azzolini P
- Babu R
- Bach R
- Badings EA
- Baeza N
- Baig M
- Baiz A
- Bajcsi É
- Balaguera J
- Balcells E
- Baldari D
- Baldus S
- Bali H
- Ballantyne C
- Ballmer P
- Banerjee S
- Bang-Hansen T
- Banikova A
- Bankowski D
- Banks K
- Bansal M
- Baraona F
- Barber C
- Barber C
- Barbir M
- Barillas O
- Barnes D
- Barnett O
- Barr C
- Barrett J
- Barringhaus K
- Barron M
- Bartels GL
- Basilio E
- Bass M
- Bassand J
- Bassand JP
- Bassand JP
- Basso V
- Bata I
- Battikadi S
- Battin D
- Bauer B
- Baumanns S
- Bautista J
- Bayat J
- Bayer M
- Bayer M
- Bayles A
- Bazzi A
- Beaudry M
- Bedoya R
- Been M
- Belicova M
- Bell K
- Belle L
- Beloscar J
- Beltran R
- Beltrano MC
- Ben-Aharon J
- Ben-Yehuda O
- Benetar J
- Bengtsson PO
- Bennermo M
- Bennett J
- Benyahya L
- Beresford P
- Berezniakov I
- Berger M
- Berger-Kucza A
- Bergeron J
- Berglund M
- Berglund R
- Bergsten J
- Berk M
- Berli M
- Bernardi D
- Berra F
- Berrospi P
- Bertolet B
- Bescos L
- Bethea C
- Bethencourt A
- Betti I
- Betzu R
- Bhalla H
- Bhalodkar N
- Bhargava M
- Bhargava R
- Bhargavi M
- Bhesania T
- Biasucci L
- Biedermann B
- Bikkina M
- Bilazarian S
- Bilodeau N
- Bin Ismail O
- Binaghi G
- Birkemeyer R
- Birnbaum Y
- Bishop A
- Bishop B
- Bishop C
- Bissett J
- Bissett J
- Bittel B
- Bitzer V
- Bjornstad H
- Blacher MG
- Blais D
- Blank E
- Blazing M
- Blazing M
- Blazing M
- Blazing Michael A.
- Blessing E
- Block D
- Bluguermann J
- Blumberg E
- Bobek M
- Bocconcelli P
- Bocconcelli P
- Bodanese L
- Bodenstein W
- Boehm S
- Bogomolny N
- Bohle D
- Bohlscheid V
- Bohorquez R
- Bohula Erin A.
- Boliek W
- Bolli R
- Bolsman C
- Bonatti S
- Bondi L
- Bondio M
- Bone C
- Bonnet J
- Bono J
- Book K
- Boomer L
- Boos C
- Botero R
- Bottzauw J
- Botwin S
- Boudriot E
- Bouvier JM
- Bowden W
- Bozek B
- Bradford L
- Bradford L
- Brady A
- Brady A
- Brady A
- Braga J
- Branca G
- Branny M
- Branzi A
- Braun P
- Braunwald Eugene
- Breen J
- Brike C
- Britto F
- Britto F
- Britto F
- Broadwater S
- Bronnum-Schou J
- Brossoit R
- Brown C
- Brown C
- Brown C
- Brown J
- Brunelli C
- Brunelli C
- Brunk S
- Bruno N
- Brunvand H
- Brussee H
- Bryniarski L
- Budzon S
- Bueno M
- Buerke M
- Buerke M
- Bugos V
- Buijs EM
- Buijs F
- Bullivant M
- Burgess L
- Burghard S
- Burley T
- Burton J
- Buss I
- Bustamante G
- Butcher R
- Butkus E
- Butter C
- Buzetti C
- Byfuglien A
- Cabrera-Santamaria A
- CalderĂłn MJ
- Calic S
- Califf
- Calpar I
- Calzolari D
- Campbell C
- Campbell T
- Campos C
- Cannon C
- Cannon C
- Cannon Christopher P.
- Canto J
- Cappelen H
- Capucci A
- Capucci A
- Cardillo MT
- Cardinal F
- Cardoso A
- Carell E
- Carell E
- Carey C
- Carlessi C
- Carlevaro O
- Carling-Chambers L
- Carlsson F
- Carmelo M
- Carr K
- Carrageta M
- Carrageta M
- Carrageta M
- Carrié D
- Carswell BS
- Cartasegna L
- Caruso O
- Casalins M
- Casares G
- Caso P
- Caspi A
- Cassadonte F
- Cassavar D
- Cassel G
- Castoldi M
- Castro P
- Castro R
- Catarino C
- Caussin C
- Cauthren T
- Cavallini C
- Ceder-Brolin K
- Centeno E
- Centurion C
- Cepeda M
- Cequier A
- Chadwyn D
- Chae SC
- Chalavarya G
- Chambers J
- Chandler G
- Chandna H
- Chandna H
- Chandna H
- Chandra P
- Chandraratna P
- Chandrasekaran S
- Chang D
- Chang G
- Chang K
- Chang K
- Chang M
- Charng M
- Chattree K
- Chavarri M
- Chavez V
- Chee K
- Chernick R
- Chessa P
- Cheung S
- Chew D
- Chhabra A
- Chian-Yi W
- Chiariello M
- Chilakamarri V
- Childs A
- Childs C
- Chiodi L
- Chiu A
- Cho M
- Choi Y
- Cholewa M
- Chopra A
- Chopra V
- Christopher J
- Christy L
- Chronos N
- Chu A
- Chui K
- Chung W
- Ciampricotti R
- Cianflone D
- Cicia G
- Cihalik C
- Ciliberti D
- Cirillo W
- Ciuti G
- Cizinsky S
- Clarke A
- Clarus S
- Clausen H
- Clausen H
- Clavero X
- Clemmensen P
- Cleveland D
- Cleveland T
- Cloud B
- Cobos M
- Cocco N
- Coelho O
- Coetzee C
- Coffin N
- Coffman A
- Cohen B
- Cohen LE
- Cohen Y
- Coisne D
- Coldwell J
- Colfer H
- Collins J
- Collins J
- Collins T
- Colombo H
- Commerford P
- Conaway D
- Connolly T
- Constance C
- Conti M
- Cooke J
- Cooke L
- Corbalan R
- Corbalan R
- Corbett C
- Cortada J
- Corut S
- Cossett J
- Costa M
- Costantini C
- Costello T
- Cottin Y
- Coviaux F
- Coy K
- Craig M
- Crandall L
- Crawford K
- Cristaldi J
- Cristell N
- Cronje T
- Cross D
- Crutchfield B
- Cryderman C
- CsapĂł K
- Cubeddu L
- Cuccia C
- Cullen T
- Curry R
- Curtis S
- Cush S
- Cusimano S
- Cyncar R
- D'Urso M
- da Costa FA
- da Cunha C
- Dagefoerde N
- Dahiya R
- Dalby A
- Dalby A
- Dalby A
- Dale H
- Daley P
- Dalin L
- Dambrine P
- Damiano M
- Damiano S
- Damm T
- Dani S
- Daniel D
- Daniels MC
- Danse IY
- Darcel I
- Darius H
- Darius H
- Darius H
- Darius Harald
- Darnell Z
- Dauber I
- Dave R
- David M
- Davidovits S
- Davidson L
- Davis B
- Davis C
- Davis G
- Davis T
- Davis W
- Davy J
- Dawson G
- De Andrade M
- De Belder M
- de Carvalho Moreira R
- De Caterina R
- De Clippel M
- De Feo S
- De Ferrari G
- De Ferrari G
- De Ferrari Gaetano M.
- De Ferrari GM
- De Gregorio M
- de la Guia F
- de la Guia F
- De Larochelliere R
- de Lemos J
- De Lemos J
- De Lucca Paul
- De Maria E
- de Sa E
- de Salazar D
- de Souza J
- de Teresa E
- de Valdecilla H
- De Velder L
- De Wolf L
- Debrouwer K
- Decker S
- DeFranco A
- Del Core M
- del Rio A
- Dela Cruz C
- Delahaye F
- Delgado J
- Delio-Cox B
- Della Siega A
- Dellatorre M
- Dellborg M
- Dellborg M
- Dellborg M
- Delport E
- Demarcq JM
- Dempsey K
- Den Hartog FR
- DeRaad R
- Desai V
- Desalca M
- DeSimone L
- DeVault S
- Devlin G
- Dhooghe G
- Di Biase M
- Di Fazio J
- Di Pasquale G
- Diadema B
- Dias D
- Dickinson D
- Dietz S
- Dietz W
- Diffenback M
- Dignen K
- Dijkshoorn-Giesen AH
- Dimenna J
- Diogo A
- Dion D
- Dionisopoulos P
- Dirkali A
- DiVito P
- Dobies D
- Dodt K
- Doerr M
- Dohmann H
- Dohmann H
- Domingo D
- Donegan R
- Donnelly B
- Donovan C
- Dos Santos ES
- Dos Santos LB
- Doty W
- Doucet M
- Doughty A
- Douglas L
- Dourmap-Collas C
- Doux N
- Dragu R
- Drenning D
- Drexel H
- Droste HT
- Duarte YC
- Dubiel J
- Dubois-Rande JL
- Duda N
- Duengen H
- Dujardin J
- Dujardin K
- Dunselman PH
- Dupuis R
- Duris T
- Duris T
- Duris T
- Duronto E
- Dussaubat A
- Dutra O
- Dwenger E
- Dzupina A
- Eaton C
- Eaton C
- Eaton G
- Ebelt H
- Eber B
- Ebrahim I
- Ebrahimi R
- Effat M
- Effron B
- Egger F
- Egido J
- Eisenberg D
- Eisenberg S
- Eisenberg S
- Eisenhauer M
- Ekpo E
- El Allaf D
- El Jarroudi M
- El Khadra M
- El Mansour N
- Elbaz M
- Eldar M
- Elis A
- Ellis J
- Elmore N
- Elsner G
- Emanuele V
- Encina L
- Erickson B
- Eriksson K
- Eriksson M
- Erlinge D
- Ervin F
- Erwin J
- Escalante A
- Escalera P
- Escande M
- Escobar E
- Escorihuela A
- Esham G
- Esplugas E
- Esteban I
- Evans M
- Ezechiels JP
- Facchi TL
- Facciorusso A
- Fadel M
- Fageraas ER
- Fahdi I
- Fahdi I
- Fanelli R
- Fanelli R
- Fanuele M
- Farhat N
- Farley A
- Farnier M
- Fast JH
- Fasulo A
- Fattore L
- Faucett S
- Fauser CG
- Faynyk A
- Fedacko J
- Fedele Francesco
- Feld RJ
- Feldman T
- Fele N
- Felgueres M
- Felix S
- Felten W
- Fenton S
- Ferdinandis H
- Fernandes A
- Fernandez H
- Fernandez R
- Ferrante R
- Ferrari M
- Ferraz RF
- Ferreira AR
- Ferres R
- Feskov O
- Fiala T
- Fielding M
- Fife B
- Fikes W
- Filardi P
- Filipiak K
- Fine D
- Fini G
- Finkle C
- Firek C
- Firth B
- Fischell T
- Fishbein G
- Fishberg R
- Fisher M
- Fisher R
- Flagstad E
- Fletcher A
- Flock C
- Flores A
- Flores E
- Fluck D
- Foeger B
- Fogel A
- Foltz J
- Fonseca Y
- Forgione C
- Forgione M
- Forrest T
- Forsgren M
- Fortuin D
- Foschi ML
- Fosse L
- Foster B
- Foster G
- Foster R
- Francek L
- Franco S
- Frank H
- Frank S
- Freick M
- French W
- Friedman B
- Froger-Bompas C
- Froufe J
- Fuchs S
- Fuentes F
- Fujise K
- Funck F
- Funiak S
- Furber A
- Gabriel G
- Gabrielli D
- Gacem A
- Gaciong Z
- Gaddi O
- Gagne C
- Gajek J
- Galindo A
- Galinier M
- Gall J
- Gall K
- Gallelli I
- Galli M
- Gallino A
- Galvez D
- Garbarino J
- Garcia C
- Garcia PA
- GarcĂa C
- GarcĂa M
- Garg M
- Garri F
- Garvey M
- Gaspardone A
- Gatti C
- Gauthey J
- Gauthier M
- Gavazzi A
- Gavina C
- Gavish D
- Gay A
- Gazmuri R
- Gealel Z
- Gelormini J
- Gencheff N
- Genest J
- Genné D
- Genova E
- Gensini G
- Genth-Zotz S
- Gergely S
- Ghannadian B
- Gharib W
- Ghigliotti G
- Ghose T
- Ghostine S
- Giannoccaro J
- Gibbons P
- Gibson T
- Gil R
- Gilbert N
- Gilchrist I
- Gill S
- Giorgio G
- Gips S
- Girala R
- Girod G
- Giugliano Robert P.
- Gjellefall B
- Glasgow B
- Glover J
- Goeing O
- Goktekin O
- Goldberg R
- Golik A
- Golino P
- Goloborodko B
- Golovtsev Y
- Gomes FL
- Gomollon J
- Gonnelli S
- Gonzalez J
- Goode G
- Gorny J
- Gosselin G
- Gottlieb D
- Gottschalck H
- Goudreau E
- Goulden D
- Goya I
- Grabscheit G
- Graceffa A
- Gradner G
- Graham B
- Grajek S
- Grande P
- Grande P
- Grande P
- Grau A
- Gravdal SA
- Graven T
- Greaves K
- Gredler F
- Greenberg A
- Greene-Nashold J
- Greene-Nashold J
- Gregorian L
- Gregory D
- Greque G
- Gress J
- Grewal G
- Grice R
- Grieco A
- Grieco A
- Griffin B
- Griffin P
- Griffith K
- Groenemeijer BE
- Grondin F
- Grosbard A
- Gross M
- Grosseto D
- Grossman E
- Groves P
- Gruberg L
- Grussmannova K
- Grändås M
- Guarini P
- Guazzarotti F
- Gudmundsson G
- Guelker H
- Guerra F
- Guerra M
- Guerrero R
- Guglielmino G
- Gugudis J
- Guiducci U
- Guillard N
- GuimarĂŁes S
- Gulba D
- Gullestad L
- Gundersen T
- Gunderson J
- Guneri S
- Guneri S
- Guneri S
- Gupta K
- Gupta M
- Gurfinkel E
- Gurfinkel E
- Gurfinkel E
- Gurlek C
- Gutierrez C
- Gutierrez M
- Gutierrez M
- Guzman E
- Guzniczak E
- Gyetvai I
- Gziut A
- Habot J
- Hacker J
- Haftel Y
- Hage C
- Hage-Korban E
- Hahn R
- Haichin R
- Hainzer D
- Hakas J
- Halabi S
- Halbach M
- Hale M
- Halkin A
- Halkosaari M
- Hall C
- Haltern G
- Halvorsen S
- Hamer A
- Hamer BJ
- Hammerman A
- Hammerman H
- Hamoud S
- Hamroff G
- Hancock T
- Handel F
- Hanefeld C
- Hanley P
- Hansen C
- Harel N
- Hargrove J
- Harjai K
- Harp L
- Harris D
- Harris L
- Harris R
- Hart H
- Hasan O
- Hatalova K
- Hatfield G
- Haude M
- Haug HH
- Hauptmann K
- Hausdorf C
- Hawkins B
- Hawkins K
- Hayek T
- Heath J
- Hebin CH
- Hedegaard B
- Heifetz S
- Held J
- Hellemans S
- Hellig S
- Helliwell L
- Hempel H
- Henareh L
- Henderson D
- Hendriks IH
- Henkin Y
- Herczeg B
- Herity N
- Herlitz J
- Herman O
- Hermans WR
- Hermany P
- Hernandez HA
- Hernández I
- Herrera M
- Herrera V
- Herrscher T
- Hershey J
- Herzog W
- Heuer H
- Heyse A
- Hicks E
- Hii C
- Hiltunen P
- Hinchion N
- Hirn S
- Hlinomaz O
- Hobbach HP
- Hodenberg E
- Hoey K
- Hofer J
- Hoffmann A
- Hogan D
- Holcomb R
- Hollenbaugh D
- Hollenweger L
- Holly D
- Holly D
- Holly D
- Holt S
- Holub M
- Holvoet G
- Holwerda NJ
- Hominal M
- Hong B
- Hong Y
- Honold M
- Hoover C
- Hoppe U
- Horak A
- Horna M
- Horowitz J
- Hotchkiss D
- Houde G
- Hradec J
- Hsieh I
- Huapalla E
- Huber K
- Hudock D
- Hughes E
- Hughes L
- Hughes M
- Hui P
- Hui W
- Hultsberg-Olsson G
- Hulyalkar A
- Humphrey K
- Humphreys R
- Huotari A
- Hussein O
- Huttunen M
- Huynh T
- Hysing J
- HĂĄrdhammar P
- Iacona MA
- Iby M
- Ieva R
- Iglesias G
- Iliceto S
- Im KyungAh
- Imburgia M
- Indolfi C
- Isaza D
- Isaza D
- Isaza D
- Istfan P
- Iwaoka R
- Izzo M
- Jabal K
- Jaboureck O
- Jackson S
- Jafar M
- Jan M
- Janek B
- Jankielewicz J
- Janosik D
- Janus M
- Jaramillo C
- Jaramillo C
- Jaramillo M
- Jaramillo N
- Jarvenpaa J
- Jaworska K
- Jean M
- Jefferson D
- Jenkins L
- Jensen BS
- Jensen J
- Jensen T
- Jeong J
- Jeong MH
- Jernberg T
- Jimenez R
- Jinich D
- Jirak P
- Joffe I
- Joffe I
- Jofre C
- Johanson P
- Johansson J
- Johansson K
- Johansson S
- Johnson J
- Johnson J
- Johnson J
- Johnson S
- Joly E
- Jonas J
- Jones A
- Jones A
- Jones D
- Jones M
- Jones S
- Jones S
- Jorda R
- Jortveit J
- Josephson R
- Jourdain P
- Juanatey J
- Juarez S
- Juhela S
- Jukema J
- Jukema J
- Jukema J. Wouter
- Jung W
- Juonala M
- Juvonen J
- Kabour A
- Kaddatz J
- Kadel C
- Kadziela J
- Kaeaeb S
- Kahn Z
- Kai W
- Kainulainen R
- Kakavas P
- Kalarus Z
- Kalkman C
- Kamalesh M
- Kammler J
- Kannampuzha P
- Kapila D
- Kaplan P
- Kapoor A
- Kappel D
- Karacaglar E
- Karas S
- Kardos A
- Karlsson J
- Karny M
- Karpenko O
- Kasliwal R
- Katerenchuk I
- Katona A
- Katsaropoulos J
- Katz A
- Kaul U
- Kawalek P
- Kawecka-Jaszcz K
- Kaya U
- Kayikcioglu M
- Kazi F
- Kazik A
- Kedia A
- Keim S
- Kelley M
- Keltai M
- Keltai M
- Keng A
- Kennett J
- Kent K
- Kenéz A
- Kereiakes D
- Kervinen H
- Kesaniemi A
- Kesaniemi A
- Kesselbrenner M
- Kesäniemi A
- Ketroser R
- Khalil J
- Khan M
- Khan S
- Khan W
- Khoury S
- Khudyak Y
- Khwanda A
- Kiam O
- Kieval J
- Kilbride S
- Kilimnik M
- Kim C
- Kim H
- Kim J
- Kirby A
- Kirby A
- Kirschner R
- Király C
- Kitagawa H
- Klausen I
- Klauss V
- Kleiman N
- Klein M
- Kleinertz K
- Kleinrok A
- Klementowicz P
- Klepper V
- Klinke P
- Klug E
- Knap P
- Knops K
- Knutson T
- Kobayashi J
- Koch A
- Koeber L
- Kokis A
- Kolman É
- Kominek M
- Konarzewski M
- Koncz J
- Kondo N
- Kong S
- Koolen J
- Kopcik D
- Kopytsya M
- Koren M
- Kormann A
- Korzeniak R
- Kosior J
- Kosonen P
- Kostuk W
- Kotila M
- Kouraki K
- Kouz S
- Koval O
- Kovalskyy I
- Kovács Z
- Kozina J
- Kraiz I
- Krajci P
- Kral J
- Kramer J
- Krapf R
- Kreisberg B
- Krekorian S
- Kretzschmar D
- Kreuzer J
- Kriete M
- Kristensen K
- Kristensen T
- Krucoff M
- Krzyzanowski M
- Kubik L
- Kuehlkamp V
- Kuijper AF
- Kujawski T
- Kultursay H
- Kumar K
- Kumar N
- Kumar S
- Kumar S
- Kumkumian G
- Kupfer J
- Kuvin J
- Kvill L
- Kwiatkowska D
- Kwok K
- Kwon H
- Kyselov S
- Kyyak Y
- Laage-Petersen J
- Laanmets P
- Labib A
- Labib S
- Labovitz A
- Labroo A
- Lachterman B
- Lafitte B
- Lai K
- Lakeman N
- Lalonde T
- Lamich R
- Lamy A
- Lancaster L
- Lancellotti P
- Lane B
- Lang I
- Langevin E
- Langford E
- Lapostol C
- Lapp H
- Larsson L
- Laschewski B
- Laskoe B
- Latham R
- Lau-Sickman A
- Laufs U
- Laukkanen J
- Lavine P
- Leader R
- Lebedynska M
- LeClerc K
- Ledbetter S
- Lee C
- Lee D
- Lee K
- Lee S
- Lee W
- Leesar M
- Lefebvre P
- Lefkowitz C
- Leggett J
- Legros G
- Lehman R
- Lehmann J
- Lehto S
- Leibowitz D
- Leisch F
- Leitao M
- Leitch J
- Lemay C
- Lemmertz K
- Lemoine I
- Lenderink T
- Leroy F
- Lesniak-Sobelga A
- Lesseliers H
- Lester F
- Lester J
- Leung C
- Levite H
- Levy T
- Lewis B
- Lewis B
- Lewis B
- Lewis Basil S.
- Lewis D
- LeĂŁes P
- Liberty I
- Lieber I
- Lieberman S
- Lied A
- Liem AH
- Lilleberg J
- Lilwall L
- Lin M
- Linhart A
- Linka A
- Lino EA
- Linssen GC
- Lioy E
- Lippe B
- Lips S
- Lipson A
- Lipson L
- Lisbeth A
- Lishner M
- Liston M
- Little T
- Little W
- Liu M
- Liu S
- Lloyd E
- Lobur E
- Loffredo K
- Lohman J
- Lok DJ
- Lombardi A
- Lombardi W
- Long P
- Lonn E
- Loogna I
- Looney A
- Lopez C
- Lopez C
- Lopez J
- Lopez M
- Lopez V
- Lopez-Sendon J
- Lopez-Sendon J
- Loukinen K
- Loureiro J
- Loxton A
- Loyo J
- Lozada A
- Lozano A
- Lozano T
- Lubelsky B
- Lui H
- Luke R
- Lund L
- Lundell L
- Lundgren C
- Lunetta M
- Luoma J
- Lupkovics G
- Lurie M
- Lush A
- Lutay Y
- Luther A
- Luukkonen J
- Lycksell M
- Lyster M
- LĂłpez A
- M'yakinkova L
- Ma P
- Mabin T
- MacDonell A
- Macek V
- Mach F
- Mach F
- Mach F
- Machado VM
- Macin S
- Macioce-Caffas A
- MacNicholas D
- Maffeo H
- Mafrici A
- Magedanz ÉH
- Magi A
- Mahenthiran J
- Mahon K
- Maia L
- Mak V
- Makam S
- Malhotra S
- Malhotra V
- Malik A
- Mamdani S
- Mancisidor P
- Mancisidor P
- Mandviwala M
- Manenti ER
- Mangin L
- Manjunath C
- Mankowski J
- Manns D
- Manocha P
- Mansourati J
- Mante J
- Manzur F
- Maquin-Mavier I
- Marco P
- Mardis R
- Marechal P
- Marenzi G
- Maresta A
- Margheri M
- Margolis J
- Mariani P
- Marin Neto J
- Marin E
- Marino J
- Marino R
- Markenvard J
- Markov G
- Markowicz E
- Marmol R
- Marotta C
- Marques N
- Marques V
- Marra S
- Marshall J
- Marsters M
- Martelet M
- Marti J
- Martin C
- Martin J
- Martin S
- Martinez M
- Martinez S
- Marusakova M
- Mascellanti M
- Mascia F
- Mascolo R
- Masroor M
- Mastouri R
- Mateus P
- Mathur A
- Mathur A
- Mathur A
- Matino MG
- Matson E
- Matsumura M
- Matthews B
- Mattleman S
- Mattos M
- Maurer G
- Maurer G
- Maurer G
- Mauro D
- May O
- Mayer N
- Mayer O
- Mayr H
- Mazurek W
- Mazzantini S
- Mazzella M
- Mazzurco S
- McAllister A
- McCagg Amy
- McCallum A
- McClements B
- McClung J
- McCullum K
- McDonough C
- McElroy D
- McEneaney D
- McEneaney D
- McGarr K
- McGarvey J
- McGreevy M
- McGuire DK
- McKeag N
- Mckenna K
- Mckissick S
- Mckissick S
- McLachlan J
- McLaurin B
- McNamara J
- McNeill A
- McPherson C
- McPherson J
- Mcsorley J
- Mechem C
- Medina F
- Medina J
- Medina MF
- Meengs M
- Mego D
- Mehta K
- Mehta R
- Mei-Juan C
- Meier AW
- Meinhardt G
- Meissner-Dengler S
- MejĂa HD
- Melegrito K
- Melin B
- Melin J
- Menapace F
- Mendell A
- Mendelski AM
- Mendelson R
- Mendoza F
- Menegato A
- Meneveau N
- Mennuni M
- Menon R
- Menozzi C
- Mente T
- Merkely B
- Merveil-Ceneus B
- Mestdagh I
- Metzger DC
- Metzler B
- Meyer-Monard S
- Meyerrose G
- Mező I
- Miccoli F
- Michel K
- Mickiewicz-Pawlowska M
- Micko K
- Miekus P
- Mielecki W
- Milesi R
- Milhous JG
- Miller E
- Miller M
- Miller M
- Mimoso J
- Mincher L
- Minneci C
- Minor S
- Miranda LF
- Mirelis J
- Mitchell B
- Mitrovic V
- Mittal S
- Mittal S
- Moccetti T
- Modena M
- Mogrovejo W
- Mohamed Z
- Moles K
- Molina A
- Molla C
- Molnar K
- Moltrasio M
- Monteiro P
- Monteiro S
- Moodley R
- Mooney P
- Moore C
- Moore S
- Moraes Junior J
- Morales R
- Morales R
- Moran J
- Morbach S
- Moreira JI
- Moretti L
- Morgado S
- Moriarty A
- Moriel M
- Morillo A
- Morin R
- Morocutti G
- Morrison H
- Morrison Z
- Morrissette J
- Moscogiuri MG
- Moscoso R
- Moscovic M
- Mosseri M
- Mostel E
- Motovska Z
- Mouallem J
- Mouco OM
- Movahed M
- Mudra H
- Muegge A
- Mueller H
- Mueller ME
- Mueller O
- Mueller-Ehmsen J
- Muenzel T
- Muhlestein B
- Mukherjee A
- Mukherjee S
- Mullasari A
- Mumford T
- Munir A
- Munoz J
- Munshi K
- Murdock D
- Murray A
- Murray C
- Murty GS
- Musella F
- Musial W
- Musina R
- Musliner Thomas A.
- Mustonen J
- Muzalewski P
- Myers G
- Mäntylä P
- Nadar V
- Nagy A
- Nagy E
- Nahhas A
- Naik S
- Nair D
- Nani S
- Narayan H
- Narayanappa S
- Naslund U
- Nassiacos D
- Navarro M
- Navarro P
- Navas JP
- Nawrocka S
- Negus B
- Neidhardt J
- Nelson C
- Nelson G
- Nelson M
- Nelson S
- Nesmith J
- Nesterak R
- Ng CK
- Nguyen N
- Nguyen T
- Nickenig G
- Nicolau JC
- Nicolau JC
- Nicolau JC
- Nicu M
- Niederl E
- Nielsen AJ
- Nielsen H
- Nielsen T
- Nienaber C
- Nierop PR
- Nigro F
- Nijmeijer R
- Nikkila M
- Nikonov V
- Nolan V
- Noorman C
- Nordeng J
- North WK
- Norwood D
- Novo S
- Novobilsky K
- Nowalany-Kozielska E
- Nunes LP
- Nygaard A
- Nygaard O
- Nygaard T
- Nyland J
- Nyman K
- NĂłbrega J
- Núñez A
- Occhiuzzi E
- Ochs H
- Oezcelik C
- Ogorek M
- Ohlmann P
- Olaru IA
- Olbrich H
- Oldoino E
- Olivari Z
- Oliveira J
- Oliver T
- Olufsen M
- Omar B
- Oomman A
- Ophuis AJ
- Ophuis T
- Ophuis TO
- Ophuis Ton Oude
- Oral I
- Orchard R
- Orosz S
- Orozco A
- Ortgren L
- Osman A
- Osores F
- Osterhues H
- Ostfeld R
- Oswald M
- Otterstad J
- Ouellette M
- Ouimet F
- Overman A
- Ovize M
- Owens S
- Pachinger O
- Padmanabhan T
- Pagnamenta A
- Paillard F
- Pais J
- Paiva M
- Palano F
- Palazzolo M
- Pallie S
- Palma A
- Palomaki A
- Paloscia L
- Pancaldi L
- Panchal V
- Pandey A
- Pandey P
- Paniagua VA
- Pantaleoni M
- Paolini E
- Pappas J
- Pappas J
- Paraschos A
- Paris AP
- Parkhomenko A
- Parkhomenko A
- Parkhomenko A
- Parrott C
- Pasaron CD
- Pascual J
- Pasha SS
- Pasquini J
- Patel P
- Paterno C
- Patrizi G
- Patti J
- Paulowski J
- Pauschinger M
- Pavesi C
- Pavesi PC
- Pavlides A
- Pavlides A
- Pazzano AS
- Peacock G
- Pearce D
- Pearce M
- Pearson A
- Peck C
- Pedersen LR
- Pedersen MS
- Pedersen T
- Pedersen T
- Peeler D
- Pegge N
- Peil A
- Pella D
- Pelletier L
- Pelouch R
- Penaherrera E
- Penaloza N
- Pennock G
- Penny W
- Penny W
- Perdomo I
- Pereira R
- Pereira RV
- Perez J
- Perez J
- Perez L
- Perez O
- Perlman R
- Perlman R
- Perna G
- Petersen J
- Petersen J
- Petrino M
- Pettyjohn F
- Petyunina O
- Phillips C
- Phillips W
- Pichler F
- Pichler M
- Picone M
- Piegas L
- Pieper M
- Pillai K
- Pillai K
- Pillay T
- Pimentel Filho P
- Ping-Han L
- Pinheiro L
- Pinho T
- Piovaccari G
- Pirenne B
- Pirozzi E
- Pistorius K
- Pitha J
- Plaev T
- Platner N
- Plomp J
- Podczeck-Schweighofer A
- Podpera I
- Poggio L
- Pohludkova L
- Poirier R
- Polacek P
- Polasek P
- Polgár P
- Poli M
- Pollak A
- Pollock S
- Poloczek M
- Polonski L
- Pongas D
- Ponikowski P
- Popova K
- Porcu M
- Porcu M
- Porter A
- Porzer M
- Pos L
- Posma JL
- Pospisilova E
- Poulard J
- PoĂłr F
- Prashad R
- Presbitero P
- Pretorius M
- Price A
- Price R
- Priesnitz T
- Prior J
- Procopio G
- Prouty D
- Providencia L
- Pruitt H
- Prunier F
- Précoma D
- Puccioni E
- Puel J
- Pulkowski G
- Puri S
- Purvis J
- Puzniak M
- Pye M
- Pytlewski G
- PĂ©rez L
- Quesada R
- Quick A
- Quick A
- Quintana O
- Qureshi I
- Qureshi M
- Quyyumi A
- Radyk M
- Raeder T
- Rafols M
- Ragni M
- Rahimtoola A
- Rahn G
- Raisinghani A
- Raiskinmäki S
- Rajala A
- Ralfkiaer N
- Rama P
- Ramabadran R
- Ramabadran RS
- Ramamurthee K
- Ramgadoo M
- Ramirez M
- Ramirez M
- Ramnarine R
- Ramos A
- Ramos G
- Ramos H
- Ramsay D
- Ranasinghe S
- Rani M
- Rankin J
- Rao C
- Rao D
- Raouf N
- Rapezzi C
- Rasmussen O
- Rasmussen S
- Ravi P
- Rebolo I
- Reddy G
- Reddy K
- Reddy K
- Reddy K
- Reddy P
- Reeves R
- Reges P
- Reich D
- Reichert P
- Reis R
- Reist Craig
- Rekosz J
- Renard M
- Rendon N
- Renton J
- Reppel M
- Reszka Z
- Revere C
- Reyes L
- Rezkalla S
- Rha S
- Rhule V
- Riba A
- Ribeiro J
- Ribeiro V
- Ricart J
- Richards AM
- Rickli H
- Riddell J
- Riddell L
- Rider J
- Ringstad R
- Risenfors M
- Rittgen J
- Rivera E
- Rivera W
- Rivlin E
- Rizvi M
- Rizzo A
- Roach A
- Robert M. Musliner T
- Roberts P
- Robeson D
- Robson H
- Rocco D
- Rocha R
- Rocha RM
- Rodrigues A
- Rodrigues E
- Rodriguez J
- Rodriguez J
- Rodriguez M
- Rodriguez M
- Rodriguez-Ospina L.
- RodrĂguez M
- Roethlisberger C
- Rogers W
- Roguin N
- Rohac F
- Rohrbeck S
- Roldan JM
- Romeo F
- Roncales F
- Ronner E
- Roongsritong C
- Roos J
- Roos J
- Roosen J
- Rosales D
- Rose J
- Rosenqvist U
- Rosenschein U
- Rosero F
- Roseva-Nielsen N
- Rossi M
- Rossi P
- Rossi P
- Rossi R
- Rotella G
- Roth J
- Roth S
- Rousseau S
- Roussine V
- Roux J
- Roy M
- Roy M
- Royuela N
- Rozenman Y
- Rubio A
- Rudenko L
- Ruggieri C
- Ruiz A
- Ruiz N
- Ruiz R
- Ruiz S
- Rukavina M
- Rupka D
- Rupprecht H
- Russell J
- Russo P
- Russo V
- Rusterholtz L
- Ruzyllo W
- Ruzyllo W
- Ruzyllo W
- Ruzyllo Witold
- Rybicka-Musialik A
- Ryttberg B
- Saaibi J
- Saaibi J
- Saba F
- Sabatine M
- Sabatino K
- Sabharwal J
- Sacco A
- SaccĂ S
- Saeed B
- Sahin T
- Sala J
- Salamon C
- Salazar D
- Salazar F
- Salman W
- Saltiel F
- Samad B
- Sameshima S
- Sample S
- Samul W
- San Jose J
- Sanchez A
- Sanchez G
- Sanchez I
- Sanchez L
- Sandler A
- Sandrin F
- Saner H
- Santoro G
- Santos J
- Santos R
- Sanz A
- Sanz R
- Sapra R
- Saraiva J
- Sarvan M
- Saucedo J
- Savini E
- Savolainen K
- Scala O
- Scalzone A
- Schaefer A
- Schaefer J
- Schaeufele T
- Schallert G
- Schantz M
- Scheffel M
- Scheffler U
- Schenks R
- Schieber M
- Schieffer B
- Schiele F
- Schifferdecker B
- Schlaeffer F
- Schlaepfer H
- Schlesner C
- Schmidt A
- Schmidt E
- Schmidt E
- Schmuck R
- Schneider C
- Schneider H
- Schneider R
- Schneider W
- Scholtz W
- Schoors D
- Schrank J
- Schuler P
- Schulze H
- Schulze M
- Schunkert H
- Schwaiger P
- Schwartz B
- Schwarz L
- Schwinger R
- Schygiel P
- Scioli R
- Scirica B
- Scollo V
- Scott D
- Scott R
- Scuri P
- Seabra AM
- Sears M
- Sease D
- Segura E
- Sejkova B
- Selas M
- Senaratne M
- Senni M
- Senol U
- Seong I
- Seppänen V
- Serafin A
- Sereg M
- Serrano C
- Sethi S
- Seung K
- Seung KB
- Seung KB
- Severa L
- Severson L
- Shafiq N
- Shah A
- Shah D
- Shah R
- Shaikh S
- Shakespeare C
- Shanes J
- Sharma M
- Sharma S
- Sharma S
- Sharma T
- Sharow A
- Sharp S
- Shaw J
- Shechter M
- Sheps D
- Sheynberg B
- Shimoni S
- Shipwash T
- Shirwany A
- Shotan A
- Shoukfeh F
- Shu-Ling H
- Shumate K
- Sia J
- Sides EA
- Siegel C
- Siegel C
- Siegel C
- Sieprath S
- Sigaud P
- Signy M
- Silva D
- Silva F
- Silva P
- Silveira DS
- Silver K
- Sim K
- Siminiak T
- Simonyi G
- Singer A
- Singer A
- Singer A
- Singh N
- Singh V
- Sinha N
- Sinnaeve P
- Sitkei É
- Sjölin M
- Skatrud L
- Skatrud L
- Skjetne O
- Skjold ME
- Sknouril L
- Skogrand E
- Skonieczny G
- Skovsbøl M
- Skowasch D
- Slipp S
- Smiley W
- Smith B
- Smith K
- Smits W
- Snyder C
- Sohn HY
- Sojka G
- Sokol S
- Solar M
- Soma P
- Sommariva L
- Sonel A
- Soriano F
- Sorokivskyy M
- Soto G
- Sotolongo C
- Soucek M
- Sousa A
- Sousa C
- Soyland E
- Spac J
- Speirs S
- Spierenburg H
- Spinar J
- Spinar J
- Spinar J
- Spratt J
- Sprigings D
- Squire I
- Srp V
- St Goar F
- St Jacques B
- Stafberg C
- Stahlberg J
- Stanco G
- Stanco G
- Staneta P
- Staniloae C
- Stankova A
- Stapleton DD
- Steel K
- Stefanini E
- Stein B
- Stein B
- Stein G
- Stein J
- Stein R
- Steiner S
- Steinhubl S
- Steinwender C
- Stepanovova R
- Stephens W
- Stephenson L
- Stevlik J
- Stewart R
- Stifter W
- Stine R
- Stipal R
- Stockenhuber F
- Stoel I
- Stokholm E
- Stone H
- Stone J
- Stout E
- Stover T
- Striekwold H
- Striezova I
- Strootman D
- Strote J
- Stroud L
- Stroud L
- Stroud L
- Stuckey T
- Stueflotten W
- Stuij S
- Stødle RM
- Suarez M
- Subban VK
- Sullivan P
- Sumner R
- Sundholm C
- Surakanti V
- Surmitis J
- Suryaprakash G
- Sussex B
- Sutcliffe S
- Svab S
- Svahn T
- Swanepoel N
- Swart HP
- Syan G
- Sydow K
- Sykulski R
- Syvanne M
- Syvolap V
- Syzmanski E
- Szczechowicz R
- Szelényi Z
- Taeymans Y
- Tafuri L
- Taghizadeh B
- Tahirovic E
- Tahk S
- Tahon S
- Takács J
- Talledo M
- Talwar K
- Tam K
- Tamburino C
- Tamburino C
- Tang E
- Tannenbaum A
- Tannenbaum M
- Tarastchuk JC
- Tardiff S
- Tarsi D
- Tavano D
- Taverne R
- Taylor D
- Tayob F
- Tebbe U
- Tedder B
- Teixeira M
- Teklinski A
- Telck K
- Ternera A
- Terns P
- Terres W
- Terrosu P
- Tershakovec A
- Tershakovec Andrew M.
- Terzi G
- Testa M
- Thai H
- Thayssen P
- The SH
- Theroux P
- Theroux P
- Theroux P
- Theroux Pierre
- Therrien M
- Theunissen LJ
- Thew S
- Thiessen S
- Thijssen HJ
- Thomas J
- Thomas K
- Thompson M
- Thomsen K
- Thorington S
- Thornley A
- Thornton K
- Thorsen S
- Tiensuu T
- Timberg I
- Timurkaynak T
- Tiroch K
- Tjeerdsma G
- Tjerneld H
- To T
- Todd A
- Todoriuk L
- Tognon AP
- Tonkin A
- Topper M
- Toppinen A
- Torres F
- Touchon R
- Townend J
- Trachsel L
- Tracz W
- Traisnel G
- Treadwell M
- Tremblay B
- Trevelyan J
- Triana M
- Tricot O
- Trojnar R
- Troquay RP
- Trouton T
- Trusz-Gluza M
- Tsang M
- Tseluyko V
- Tsoy I
- Tucker K
- Tuma P
- Tuohy E
- Turek M
- Turnbull K
- Turner A
- Turri D
- Tutov I
- Tuxen C
- Twelker K
- Tyagi G
- Tycinska A
- Tygesen H
- Tyllo M
- Tymchak W
- Tzivoni D
- Tzuman O
- Uchida N
- Uehara RM
- Uher T
- Ukkola O
- Ultramari FT
- Underwood C
- Unks M
- Ural E
- Uretsky B
- Uretsky B
- Uricar M
- Usmiani T
- Utriainen S
- Uusinarkaus K
- Uziel-Iunger K
- Vahala P
- Vahdat O
- Vakaliuk I
- Valenzuela C
- Valpas S
- Van 't Hof A
- van Boven AJ
- van Dam C
- van de Borne P
- Van de Loo A
- Van de Werf F
- Van de Werf F
- Van Den Berg BJ
- Van Den Broeck D
- van der Bij P
- van der Sluis A
- van der Ven-Elzebroek N
- van der Weerdt A
- van der Zeijst M
- van der Zwaan C
- Van Dorpe A
- Van Dorpe A
- van Eck M
- van Es RF
- Van Hal JM
- van Hessen MW
- Van Kalmthout PM
- van Kempen LH
- Van Kieu C
- van Lennep HW
- van Loo LW
- Van Miert N
- van Nes E
- van Rossum P
- van Ruijven I
- Van Vlies B
- Van Zyl L
- Vanhauwaert B
- VanNatta B
- Vantomme C
- Varela P
- Varghese T
- Varma S
- Varner C
- Varroud-Vial N
- Vasiliauskas T
- Vazan A
- Vazquez A
- Veenstra W
- Vegsundvaag J
- Vejvoda J
- Velasquez D
- Velasquez J
- Veldmeijer S
- Velle H
- Venn-Edmonds C
- Vercauteren S
- Vertes G
- Vervoort G
- Veselka J
- Vestager KM
- Vetrano A
- Vicari R
- Vicente C
- Vicentini A
- Vichi V
- Viergever EP
- Vijay N
- Villa A
- Villa E
- Villa F
- Villani G
- Visconti L
- Viso M
- Vitovec J
- Vizel S
- Vlastaris A
- Vogel C
- Voitk J
- Voitk J
- Voitk J
- Volpe M
- vom Dahl J
- Von Bakonyi A
- Vora K
- Voss J
- Voutilainen S
- Voyles W
- Vykoukalova T
- VĂ©rtes A
- Waage K
- Waalewijn RA
- Wainstein M
- Waldo D
- Walsh S
- Walters B
- Wang Y
- Wanitschek M
- Ward P
- Ward U
- Warlits B
- Warnica J
- Washam M
- Watkins K
- Watson R
- Wead J
- Wechselberger T
- Weeks A
- Weidinger F
- Weihs W
- Weil J
- Weiss A
- Weller C
- Werner G
- Werter CJ
- Wertheimer J
- Wesley D
- Westecott B
- Westenburg J
- Wheeler M
- Wheeler M
- Whitaker T
- Whitcomb C
- White D
- White H
- White H
- White J
- White J
- White J
- White Jennifer A.
- Wiegman P
- Wiemer M
- Wikström P
- Wilhelm J
- Wilhelm M
- Wilks J
- Willems FF
- Williams P
- Williams S
- Williams V
- Wilson S
- Wilson V
- Wilson V
- Winestock J
- Winther-Friis B
- Wirtemburg P
- Wiseman A
- Withagen AJ
- Witsaman S
- Witt N
- Witzling V
- Wiviott Stephen D.
- Wohns D
- Wojciechowska C
- Wong A
- Wong B
- Wong G
- Wong S
- Wong Y
- Woodhead G
- Worner F
- Worthley S
- Wright L
- Wright T
- Wright W
- Wrzosek B
- Wu C
- Wu L
- Wu W
- Wyman P
- Yalcin R
- Yanez L
- Yedinak S
- Yeh H
- Yen M
- Yeo D
- Yigit Z
- Yildirir A
- Yildiz Z
- Yoon J
- Yoon M
- Young C
- Yovaniniz P
- Yu C
- Yu W
- Yuval R
- Zahn R
- Zakhary B
- Zaluska R
- Zambahari R
- Zanini R
- Zanini R
- Zanolin D
- Zapata M
- Zarandon R
- Zeiher A
- Zeltser D
- Zeman K
- Zemberova A
- Zemour G
- Zender H
- Zeymer U
- Zhukova Y
- Ziegler B
- Zimlichman R
- Zimmerman T
- Zimmermann R
- Zingarelli A
- Zirkle J
- Zucchetti C
- Zughaib M
- Zuidgeest JA
- Zuppiroli A
- Zwart PA
- Zweiker R
- Ă…ngman K
- Édes I
- Ă–stberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit
Evolocumab and clinical outcomes in patients with cardiovascular disease
- Author
- Abelson M
- Aboufakher R
- Abrahamsen Te
- Accini Mendoza Jl
- Acheatel R
- Ackermann D
- Adamkova V
- Adams M
- Adlam D
- Aggarwal R
- Aggarwal S
- Ahsan A
- Ainsworth P
- Airody Govinda R
- Akai A
- Ako J
- Al-Bahrani A
- Al-Joundi T
- Aldegather J
- Aldrete Velasco Ja
- Alfieri A
- Alt I
- Alzohaili O
- Amerena J
- Amin J
- Amoedo R
- Amuchastegui M
- Anderson T
- Andreka P
- Andreotti F
- Angoulvant D
- Ansell B
- Antalik L
- Antkowiak-Piatyszek K
- Appel K
- Arakawa T
- Arana Londoño C
- Ardissino D
- Ardito Wr
- Arkhipov M
- Arsenescu-Georgescu C
- Asamoah N
- Ascaso Gimilio Jf
- Atar S
- Atassi K
- Athyros V
- Auerbach E
- Awtry E
- Baass A
- Badariene J
- Badat A
- Badila E
- Bae J
- Baigent C
- Bain S
- Baird I
- Baker J
- Balbay Y
- Baldari D
- Ballantyne C
- Bammert A
- Banach M
- Bandh S
- Banerjee S
- Banik M
- Banikova A
- Barbarash O
- Barcinas R
- Barnum O
- Barroso de Souza Wk
- Bart B
- Barton J
- Bata I
- Batalla E
- Bayat J
- Bazzoni Ruiz Ae
- Bednarkiewicz Z
- Beer Hj
- Begg A
- Beltrame J
- Bendermacher P
- Benton R
- Berger C
- Bergeron J
- Bergler-Klein J
- Berglund S
- Berlacher P
- Bernstein M
- Bertolet B
- Bertolim Precoma D
- Bhagwat R
- Bhargava R
- Bhushan R
- Biasucci Lm
- Bilianou H
- Blagden M
- Blaha V
- Blasko P
- Blicharski T
- Blignaut S
- Blokhin A
- Blumberg E
- Bodanese Lc
- Bokern M
- Bolshakova O
- Bonaca Mp
- Bonnet B
- Bosiljanoff P
- Boswijk D
- Botero Lopez R
- Bourhaial H
- Bousboulas S
- Brabec T
- Brezina B
- Bronnum-Schou J
- Brotanek J
- Broughton R
- Brown C
- Brown Wv
- Bubnova M
- Budoff M
- Burgess L
- Burianova H
- Burrough B
- Butler R
- Buysschaert I
- Bystryk L
- Capps N
- Cappuccio F
- Cardona Muñoz Eg
- Carhart R
- Cariou B
- Carr K
- Case C
- Castellanos Bueno R
- Catez E
- Caulfield M
- Cayla G
- Cech V
- Cepelak M
- Ceska R
- Cha J
- Chandra L
- Chapman K
- Charlier F
- Charng Mj
- Charvat J
- Chauhan A
- Cheek Hb
- Chehayeb R
- Chen J
- Chen X
- Chen Y
- Chenu P
- Cheung D
- Cho Y
- Choi D
- Chopra Vk
- Chorin E
- Christensen T
- Christofides E
- Cifkova R
- Civeira Murillo F
- Cizinsky S
- Clardy D
- Claxton E
- Clements B
- Cobos Jl
- Coching Rm
- Coetzer Tf
- Coisne D
- Collins J
- Colombo H
- Coman I
- Conejeros Kindel C
- Connolly D
- Constance C
- Contzen C
- Cordero Fort A
- Cornel Jh
- Coronel Arroyo Ja
- Cosmi F
- Cottin Y
- Cox N
- Crater T
- Crean P
- Croce K
- Cross D
- Crowley D
- Cruickshank K
- Cuadrado Ja
- Cui H
- Cui Y
- Cummings M
- Cuneo C
- Cunha Borges Jl
- Cure Cure Ca
- Cygler J
- Dabrowska M
- Dabrowski M
- Dahlén G
- Dai H
- Dan Ga
- Danias P
- Darius H
- Dauber I
- Dave K
- Davila W
- Davis Br
- Davis G
- Davis M
- Dawood S
- de Belder M
- De Caterina R
- De Ferrari Gm
- De Jong Dm
- De La Cruz A
- De la Peña Topete Gdj
- De los Rios Ibarra Mo
- De Meulemeester M
- De Nooijer C
- De Raedt H
- de Sa Cunha R
- De Souza J
- Dear H
- Deedwania Pc
- Delarche N
- Delgado E
- Demir M
- Den Hartog F
- Derian W
- Desai A
- Descamps O
- Desire A
- Dill S
- Diogo J
- Dixon L
- Dobkin L
- Dobratz D
- Donnelly P
- Douglas F
- Dowell A
- Doyle T
- Dronov D
- du Toit M
- Du Y
- Duarte Barbosa Ec
- Dubaniewicz W
- Duchesne L
- Dunaj M
- Dunbar R
- Durlach V
- Dutra O
- Duzenli M
- Dwivedi Sk
- Dyke C
- Dzupina A
- Earl J
- Eaton C
- Ebenbichler C
- Eberli F
- Ebrahim I
- Edes I
- Eglite R
- Egstrup K
- El Shahawy M
- Elam M III
- Elbl L
- Eliaschewitz Fg
- Elisaf M
- Ellery A
- Engel E
- Engelbrecht J
- Ercan E
- Erglis A
- Erickson B
- Erng T
- Estepar Ra
- Ezhov Mv
- Fagan T
- Fairlie H
- Falck G
- Fan Kyy
- Farhat N
- Farris N
- Farshid A
- Fedele Francesco
- Fernandes Manenti Er
- Fernandez S
- Ferrari E
- Ferreira Rossi Pr
- Ferreira J
- Ferri C
- Ferrieres J
- Fialkow J
- Filipová S
- Finlayson J
- Fiore G
- Fischer M
- Fiserova N
- Fishbein G
- Fisher M
- Floresta Am
- Focil A
- Forgosh L
- Fortuin F
- Fotherby K
- Fox C
- Frana P
- Fredrick M
- Freidlin M
- French J
- Friart A
- Fritz R
- Fujino Y
- Fujita H
- Fulop P
- Funazaki T
- Gabra N
- Gaciong Za
- Gan Hw
- Gandy W
- Gao X
- Garbocz P
- Garrahy P
- Gaudet D
- Gaunt R
- Gavish D
- Ge Z
- Geadah C
- Gelfand E
- Georgiev Bg
- Germar A
- Ghali J
- Gilpatrick M
- Giugliano G
- Giugliano Robert P.
- Glenny Ja
- Go A
- Go Y
- Goel A
- Goldenberg E
- Goloshchekin B
- Golovchenko O
- Gonnelli S
- Gonsorcik J
- Gonzalez Juanatey Jr
- Gonzalez-Galvez G
- Goralski M
- Gordeev I
- Gorog D
- Gossard D
- Gosselin G
- Gotchev D
- Gouni-Berthold I
- Graham J
- Greenwald J
- Griffin S
- Groutars R
- Grubb S
- Gruberg L
- Grzegorzewski B
- Gu Y
- Gupta D
- Gupta M
- Gustiene O
- Guyton J
- Guzik T
- Gyrina O
- Habaluyas R
- Hack T
- Haddad T
- Hage Korban E
- Hajko E
- Hala T
- Hall A
- Halperin F
- Hamet P
- Hammett C
- Hamroff G
- Han Kh
- Handelsman Y
- Hanefeld M
- Hanlon K
- Hanusch U
- Hare Po
- Harris M
- Hart R
- Hartleib M
- Harvey J
- Hasbani Eg
- Hasin Y
- Hata Y
- Hatalova K
- Hatharasinghe R
- Haught Wh
- He Y
- Hearne S
- Heller S
- Henderson D
- Henein S
- Hengstenberg C
- Hennekens Ch
- Henry B
- Henry P
- Her S
- Herczeg B
- Herman L
- Hermany P
- Hernandez Triana E
- Herrman J
- Hersbach F
- Hershon K
- Hershson A
- Herzog W
- Hess A
- Hetzel G
- Hiczkiewicz J
- Higa N
- Higashi Y
- Himeno H
- Hirayama A
- Hissa M
- Hitchcock J
- Ho C
- Hoffer E
- Hoivik Ho
- Holder S
- Homza M
- Honarpour Narimon
- Hong B
- Hornyik A
- Horrigan M
- Hosokawa S
- Hove J
- Hovland A
- Hoye A
- Hrabar A
- Hranai M
- Hsia C
- Hsieh I
- Hsieh Y
- Huang C
- Huang H
- Huang W
- Huber K
- Huling R
- Hulinsky V
- Huynh T
- Hysing J
- Ibrahim H
- Iida H
- Ilkowski J
- Illescas Diaz Jj
- Im K
- Inage T
- Inoko M
- Isermann B
- Issa B
- Issa M
- Isserman S
- Iteld B
- Ivan P
- Iwade K
- Izar Mc
- Izumiya Y
- Iñiguez Romo A
- Jaafar F
- Jackson R
- Jacovides A
- Jain A
- Janik M
- Jansen R
- Janus C
- Jardula M
- Jasinkevica I
- Jehle A
- Jelinek P
- Jelinek Z
- Jeong M
- Jeppesen J
- Jerabek O
- Jiang J
- Jiang L
- Jocson G
- Joffe I
- Johansson P
- Johnston J
- Joshi A
- Juang J
- Juergens C
- Jukema Jw
- Jupp B
- Kadokami T
- Kahri J
- Kahrmann G
- Kaigawa K
- Kaik J
- Kajiyama S
- Kakurina N
- Kanevsky E
- Kania G
- Kanno M
- Kapp C
- Karadi I
- Karakas M
- Karalis I
- Karen I
- Karpenko O
- Kashyap M
- Kassner U
- Kast P
- Katsuda Y
- Kawabata K
- Kawamitsu K
- Kawasaki T
- Kayikcioglu L
- Kazdera P
- Keech Anthony C.
- Keeling P
- Kellnerova I
- Kereiakes D
- Kerr Saraiva Jf
- Khalife K
- Khan A
- Khan B
- Khan M
- Khandait V
- Khanoyan P
- Khurana S
- Kim B
- Kim M
- Kim S
- Kim W
- Kinasz L
- King M
- Kingston D
- Kinova E
- Kirma C
- Kirstein J
- Kiss R
- Kitova L
- Kiyosue A
- Kjaernli T
- Kjaerulf Jensen H
- Klausen Ic
- Klimsa Z
- Klug E
- Klutstein M
- Knusel B
- Kobalava Z
- Kochiadakis G
- Koga Y
- Kohli N
- Koike A
- Kok J
- Koleckar P
- Kolovou G
- Kondagunta V
- Konieczny M
- Kooij A
- Kopaczewski J
- Kopytsya M
- Koren M
- Kork A
- Korsgaard Thomsen K
- Korzh O
- Kosek Z
- Kosior D
- Kostenko V
- Kostner K
- Kothiwale V
- Kovar F
- Kozlowski L
- Kozuma K
- Kraatz U
- Kracoff O
- Kramarczuk E
- Kraydashenko O
- KraŃ–z I
- Krejcova H
- Krishna J
- Kritharides L
- Krupicka J
- Kryza R
- Krähenbühl S
- Ksiezycka-Majczynska E
- Kubica J
- Kucera D
- Kuchar J
- Kuchar L
- Kuchar R
- Kucinskiene A
- Kuder Julia F.
- Kulkarni G
- Kulynych O
- Kurtz Lisboa Hr
- Kurtz C
- Kusiak D
- Kusnick B
- Kvasnicka J
- Lader E
- Ladyjanskaia G
- Lagocki S
- Lai W
- Lakatos F
- Lalmand J
- Lanas Zanetti F
- Landzberg J
- Larosa J
- Laszlo Z
- Lawless A
- Lazov P
- Le Corvoisier P
- Leaes Pe
- Lee Cy
- Lee D
- Lee S
- Leeman D
- Lehman S
- Leitao A
- Leiter La
- Leiva Pons Jl
- Lekuona Goya I
- Lennerova J
- Leon de la Fuente R
- Leon Gonzalez S
- Lepich T
- Levin P
- Levinson D
- Lewis Bs
- Li D
- Li J
- Li W
- Li X
- Li Z
- Lian Y
- Liem A
- Lieverse A
- Liew H
- Lighezan D
- Lillo J
- Lindholm C
- Link M
- Linka A
- Linsky R
- Linssen G
- Linzmeyer K
- Lip G
- Lipschitz S
- Lira Pineda A
- Liu F
- Liu Thomas
- Liu Y
- Llamas Esperon Ga
- Lo E
- Loh I
- Lok D
- Lonn E
- Lopez Alvarado A
- Lopez Santi Rg
- Lorenzatti Aj
- Lottering H
- Lowe C
- Lozada A
- Lubiszewska B
- Ludka O
- Luger A
- Lukacova J
- Lukyanov Y
- Lupkovics G
- Lutskiy M
- Lymar I
- Lynch M
- Lysek R
- LĂłpez-Miranda J
- Mach F
- Machkova M
- Mackenzie I
- Mackinnon I
- Magro M
- Mahajan A
- Makam S
- Makotoko E
- Malecha J
- Malone M
- Malynovsky Y
- Mandviwala M
- Manolis A
- Manolova A
- Mansour S
- Mantas I
- Manzur Jattin F
- Marais H
- Marcucci R
- Marcus A
- Marenzi G
- Marhefka G
- Mariat C
- Mark L
- Markdanner Lindgren L
- Markov V
- Marten I
- Maskon O
- Mathew A
- Matos P
- Matsuo H
- Matuska J
- Maus O
- Mays M
- Mazur J
- Mcadam B
- Mccormack T
- Mccullum K
- Mcdowell E
- Mcelveen W
- Mcgrew F
- Mcintyre H
- Mckinnon C
- Mclellan B
- Mcnally D
- Mcrae A
- Meengs M
- Mehta V
- Melchior T
- Melidonis A
- Mendez Machado Gf
- Mennuni M
- Merkely B
- Merlini P
- Mertzanos G
- Meshkov A
- Michel P
- Mickley H
- Militaru C
- Millan Nuñez-Cortes J
- Miller A
- Miller M
- Mirek-Bryniarska E
- Mitchell C
- Mitu F
- Mo Z
- Moccetti T
- Mohacsi A
- Mohamed Yusof Ak
- Mohammed A
- Molina de Salazar Di
- Molter D
- Monajemi H
- Moncada Corredor Ma
- Montalescot G
- Monteiro P
- Moodley R
- Mooe T
- Mooss A
- Moretti L
- Moriarty P
- Morris P
- Moschos N
- Mosiewicz J
- Motreff P
- Motylev I
- Moura Jorge Jc
- Muderrisoglu Ih
- Muir S
- Mukherjee A
- Murphy Sabina A.
- Murray J
- Murthy D
- Muzulu S
- Myshanych G
- MĂĽnzel T
- Nadar V
- Nagajothi N
- Nagy A
- Nagy K
- Nakamura Y
- Nakane H
- Nakashima E
- Nakhle S
- Namba S
- Napoli M
- Napora P
- Navarro J
- Negahban A
- Nemecek E
- Nevarez Ruiz La
- Newby D
- Newcomer Jw
- Nicolau Jc
- Nicolosi L
- Nicolson A
- Nielsen H
- Nielsen T
- Nieminen S
- Nigro F
- Nilsson L
- Noguchi Y
- Norden A
- Norheim P
- Ntaios G
- Nunohiro T
- Nyman K
- Ohmura H
- Okada M
- Okamoto H
- Oku K
- Oliveira L
- Olsen S
- Olsson A
- Olsson S
- Olsson Ă…
- Onyema D
- Oomen A
- Oosthuysen Wm
- Opitz C
- Ord J
- Oriesek R
- Orourke D
- Osea E
- Osipova I
- Oude Ophuis A
- O’Donnell M
- Pacora F
- Pai R
- Paillard F
- Panagoulis C
- Pande A
- Pandey As
- Panov A
- Papp A
- Papp E
- Parikh K
- Parkhomenko O
- Parmar M
- Pasierski T
- Pasquini J
- Pastrnakova E
- Patsilinakos S
- Paul N
- Paulweber B
- Pearlstein P
- Pedersen
- Pedersen T
- Pei H
- Pella D
- Peniston J
- Penny W
- Pentela-Nowicka J
- Pereira A
- Pereira H
- Perez Alva Jc
- Perna E
- Perrone Filardi P
- Pesant Y
- Peterfai E
- Peterka K
- Peterson S
- Petrella R
- Petrov I
- Pettersson Si
- Pharr W
- Piepiorka M
- Pierpont B
- Piippo T
- Pijanowski Z
- Pillay S
- Pimenov L
- Pimentel Filho P
- Pincetti Jofre Cp
- Pintilei E
- Pinto Sala X
- Piros Ga
- Pirro M
- Podolec P
- Podpera I
- Pogue B
- Poirier P
- Pojsl S
- Polasek R
- Poock J
- Popescu Mi
- Pothineni Rb
- Potthoff Cardenas S
- Potu R
- Pozdisek Z
- Prager R
- Prasan A
- Pretorius M
- Prokhorov O
- Przekwas-Jaruchowska M
- Pucheu Y
- Purdy D
- Purohit J
- Pye M
- Qu P
- Quintero Baiz Ae
- Rabinowitz A
- Raczak G
- Radzeviciene-Jurgute R
- Raev D
- Rahimi S
- Raisinghani A
- Rajadhyaksha G
- Rallidis L
- Ramanathan Gl
- Rammer M
- Ramos Lopez Ga
- Ramos M
- Ramstad D
- Range G
- Raoof T
- Rapezzi C
- Rasmanis G
- Rebrov B
- Rech Rl
- Recknor C
- Reddy J
- Reichert P
- Reichman A
- Reis G
- Remler R
- Rensing B
- Reschak M
- Reshotko D
- Reyes H
- Rezkalla S
- Rha S
- Rice L
- Richter D
- Rider J
- Rietzschel E
- Rigler S
- Rinke A
- Risberg K
- Rishko M
- Roberts Thomson P
- Robinson J
- Rodriguez D
- Roelandt R
- Rogelio Gg
- Rogers W
- Rojas Cg
- Roseman H
- Rosenson R
- Rosenthal A
- Rosolova H
- Rost N
- Rothschild R
- Roubille F
- Rouzier R
- Rowe W
- Rubenfire M
- Ruberg F
- Rubino J
- Rudenko L
- Rudyk I
- Runquist L
- Rupka D
- Rutherfurd S
- Rychlewska-Hanczewska A
- Rysava D
- Römer T
- Saaiman J
- Saavedra Gajardo Va
- Sabatine Marc S.
- Sabbah E
- Sabe-Affaki G
- Sacco J
- Saetre Lihn A
- Sahin T
- Sakagami S
- Sakhrani L
- Saksena R
- Saku K
- Salamon C
- Salbach P
- Samal A
- Sampietro T
- Sanabria Hd
- Sanchez Diaz Cj
- Sanchez Vallejo G
- Sanford K
- Saravanan P
- Sarkar D
- Sarvan M
- Sato K
- Satoh Y
- Savolainen M
- Saway W
- Scheen A
- Schenkenberger I
- Schernthaner G
- Schiele F
- Schiff E
- Schlau A
- Schmedtje J
- Schmidt Eb
- Schnitzler R
- Schooley C
- Schramm E
- Schreibman D
- Schäufele T
- Scott J
- Scott R
- Scott Rs
- Seaton B
- Senior R
- Senni M
- Sepulveda Varela Pa
- Sever Peter S.
- Shah A
- Shah M
- Shalaev S
- Shalek M
- Shaoulian E
- Shapiro M
- Shatylo V
- Shechter M
- Shen X
- Sherenkov A
- Sherman H
- Shifrin G.
- Shimizu M
- Shin Gj
- Shinozaki T
- Shirasawa K
- Shore K
- Shotan A
- Shustov S
- Shutemova E
- Shvarts Y
- Sigurdsson A
- Silverman S
- Sime I
- Simon W
- Simons R
- Simpson R
- Singh I
- Singhal A
- Sinhal A
- Sinzinger H
- Siostrzonek P
- Siu Cw
- Siu Sc
- Skonieczny G
- Skoumas I
- Skrobakova J
- Snyder B
- Soares Goncalves S
- Soares Piegas L
- Sochor K
- Sofley Cw
- Solanki B
- Solnor L
- Solovev O
- Solovieva E
- Somaratne R
- Sorokina I
- Sosovec D
- Sotomayor Herazo A
- Spaulding C
- Spencer R
- Spinar J
- Spinarova L
- Spriggs D
- Spyra J
- Srivastava S
- St Amour E
- Staneta P
- Stania K
- Stanislavchuk M
- Stapelberg A
- Stawowy P
- Steiner S
- Steinsapir J
- Stephens L
- Stockins Fernandez Ba
- Stonesifer L
- Stout E
- Strand J
- Strandberg Te
- Strazdiene V
- Stringam S
- Strobl D
- Stukena I
- Su H
- Subramaniam T
- Sugino H
- Sun Y
- Suomi J
- Sussex B
- Suutari A
- Svishchenko Y
- Sy Ra
- Szakal I
- Szpajer M
- Szymkowiak K
- Söderberg S
- Tahirkheli N
- Tami L
- Tan Jl
- Tanabe J
- Tang A
- Tang Y
- Tanno H
- Tarasov N
- Tarleton G
- Tarnovska-Kadreva R
- Tavares Russo La
- Tay L
- Teodorescu I
- Tereshenko S
- Terje R. Fish MP
- Terront Lozano Ma
- Teterovska D
- Thoeng J
- Thom S
- Thomas H
- Thompson C
- Thompson P
- Thomson S
- Thorgeirsson G
- Tie S
- Tikkanen Mj
- Timoteo At
- Tobin T
- Tokgozoglu Sl
- Tokunaga T
- Tomcsanyi J
- Tonino W
- Toplak H
- Torres M
- Toth K
- Travill C
- Trebacz J
- Trendafilova-Lazarova D
- Trenk D
- Treshkur T
- Trevelyan J
- Troquay R
- Tsai Cf
- Tseluyko V
- Tsoukas G
- Tudoran M
- Tyagi S
- Tydén P
- Tyszecka G
- Tzekova M
- Tziakas D
- Uehara H
- Uemura O
- Ueno T
- Uhliar R
- Ulla Mr
- Urbach D
- Urgeova L
- Vaclavik J
- Vakaliuk I
- Valdes Chavarri M
- Vally T
- Valter I
- Van Beek E
- van de Borne P
- van de Wal R
- van der Walt E
- van der Zwaan C
- Van Gaal W
- Van Hessen M
- Van Zyl L
- Vanbelle E
- Vandekerckhove H
- Vasco Salgado A
- Vawda G
- Velchev V
- Venceviciene L
- Venegas Carrillo La
- Verheye S
- Vertes G
- Veze I
- Vida Gutierrez M
- Vidotti Mh
- Viigimaa M
- Vijay N
- Vikman S
- Vinanska D
- Vintila Mm
- Violante Ortiz Rm
- Vishnevsky A
- Visman A
- Vita J
- Voevoda M
- Vogel Dr
- Volkov V
- Vomacka Z
- von Hodenberg E
- Vora K
- Vorpahl M
- Wada A
- Wagner S
- Wan Ahmad Wa
- Wang D
- Wang Huei
- Wang J
- Wasserman Scott M.
- Waxman F
- Webel R
- Webster J
- Weinberg B
- Weinstein D
- Welker J
- Wermuth S
- Westendorp I
- Weyland K
- Whitney R
- Wierzbicka K
- Wilhoit G
- Wilson S
- Wise J
- Wiseman A
- Witt N
- Wittert G
- Wiviott Stephen D.
- Wnetrzak-Michalska R
- Wollaert B
- Wood Sk
- Wozakowska-Kaplon B
- Wozniak I
- Wu C
- Wyatt N
- Wöhrle J
- Xu P
- Xue L
- Yakhontova P
- Yamamoto K
- Yamashita K
- Yan J
- Yang E
- Yang P
- Yang X
- Yang Y
- Yang Z
- Yao Z
- Yasumura Y
- Yataco A
- Yeh H
- Yena L
- Yeoman G
- Yigit Z
- Yilmaz Mb
- Yokoya K
- Yoshimichi G
- Yotov Y
- Youngman D
- Younis L
- Yuge M
- Zabowka M
- Zahn L
- Zamorano Gomez Jl
- Zarich S
- Zateyshchikov D
- Zdrenghea D
- Zechowicz T
- Zeig S
- Zemanek J
- Zeng X
- Zhang L
- Zhang X
- Zhao S
- Zheng Y
- Zheng Z
- Zhou C
- Zhu Y
- Zhurba S
- Zidkova E
- Zieba B
- Ziegler O
- Zilahi Z
- Zrazhevskiy K
- Ă–stergren J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%). CONCLUSIONS In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets