8 research outputs found
Dipole and spin-dipole strength distributions in 124,126,128,130Te124,126,128,130Te isotopes
- Author
- A Krasznahorkay
- A Krasznahorkay
- A Lepretre
- A Lepretre
- A Lepretre
- BL Berman
- Cevad Selam
- CL Biai
- DJ Horen
- E Guliyev
- E Guliyev
- F Ertugral
- F Osterfeld
- FA Gareev
- FT Baker
- GA Lalazissis
- H Akimune
- H Akimune
- H Liang
- H Quliyev
- H Sakamoto
- J Janecke
- K Pham
- L Arisoy
- L Stuhl
- Necla Cakmak
- NI Pyatov
- O Civitarese
- O Civitarese
- O Civitarese
- P Carlos
- S Unlu
- Sadiye Cakmak
- SC Fultz
- Serdar Unlu
- T Babacan
- T Babacan
- T Suzuki
- T Suzuki
- T Wakasa
- VG Soloviev
- X Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Role of Energy Balance in Cancer Prevention
- Author
- AE Civitarese
- AE Prizment
- AG Renehan
- AJ Canchola
- AO Odegaard
- AS Oxentenko
- BB Kahn
- C Doyle
- C Friedenreich
- CL Ogden
- CM Kitahara
- DE Larson-Meyer
- DP Belobrajdic
- E Azambuja de
- E Salazar-Martínez
- F Chiohn
- F Clavel-Chapelon
- FA Sinicrope
- G Haars
- JK Bassett
- JLF Bosco
- KM Flegal
- KM Flegal
- KM Flegal
- L Bessonova
- LA Healy
- LAE Hughes
- LJ Schouten
- LM Redman
- LM Redman
- LR Teras
- M Ewertz
- M Harvie
- M Kawai
- M Meydani
- MF Leitzmann
- MN Harvie
- MT Goodman
- N Parekh
- PH Lahmann
- PJ Goodwin
- R Calle
- R Suzuki
- SD Hursting
- SD Hursting
- SE Shoelson
- SG Elias
- SL Park
- VD Longo
- World Cancer Research Fund/AICR
- X Chen
- XR Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis
- Author
- A Korwitz
- A. Saskia Venne
- AE Civitarese
- AM Verhagen
- AS Venne
- AS Venne
- B Head
- BP Eckelman
- C Du
- C Frezza
- C Saunders
- D Ghezzi
- D Mossmann
- DC Chan
- DP Narendra
- DZ Mokry
- E Rettinger
- E Schrepfer
- FA Ran
- G Chen
- G Shi
- GA McQuibban
- GS Salvesen
- H Kashkar
- H Okada
- H Sesaki
- Hamid Kashkar
- Hendrik Nolte
- J Chai
- J Cox
- J Cox
- J Rappsilber
- J D Hunter
- J M Burkhart
- J M Capo-Chichi
- J M Seeger
- J R Chao
- Kai Uwe Fiedler
- L Burri
- L Griparic
- L Pernas
- L Yang
- M Freeman
- M Herlan
- M Holcik
- M Kanabus
- M Liesa
- Marcus Krüger
- N Ishihara
- P Luciano
- PJ Jost
- PM Quiros
- R Anand
- R Mannhold
- René P. Zahedi
- RJ Youle
- S Cipolat
- S Duvezin-Caubet
- S Ehses
- S Heinitz
- S Sekine
- SB Wortmann
- Shotaro Saita
- SM Jin
- T MacVicar
- T Wai
- TE Thingholm
- Thomas Langer
- VA Morais
- VG Tusher
- W Li
- X Jiang
- Y Horibata
- Z Song
- Z Wang
- ZT Schug
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its substrate spectrum. Our data identified the mitochondrial pro-apoptotic protein Smac (also known as DIABLO) as a PARL substrate. In apoptotic cells, Smac is released into the cytosol and promotes caspase activity by inhibiting inhibitors of apoptosis (IAPs). Intramembrane cleavage of Smac by PARL generates an amino-terminal IAP-binding motif, which is required for its apoptotic activity. Loss of PARL impairs proteolytic maturation of Smac, which fails to bind XIAP. Smac peptidomimetics, downregulation of XIAP or cytosolic expression of cleaved Smac restores apoptosis in PARL-deficient cells. Our results reveal a pro-apoptotic function of PARL and identify PARL-mediated Smac processing and cytochrome c release facilitated by OPA1-dependent cristae remodelling as two independent pro-apoptotic pathways in mitochondria
Transcriptional Assessment by Microarray Analysis and Large-Scale Meta-analysis of the Metabolic Capacity of Cardiac and Skeletal Muscle Tissues to Cope With Reduced Nutrient Availability in Gilthead Sea Bream (Sparus aurata L.)
- Author
- A Bermejo-Nogales
- A Conesa
- A Saera-Vila
- A Saera-Vila
- AA Teleman
- AE Civitarese
- AM Singh
- AP Palstra
- B Gershman
- B Martin
- BM Cleveland
- BR Zeeberg
- C Desert
- CF Spurney
- CG Son
- D Baron
- D Baron
- D Baron
- D Baron
- D Baron
- D Baron
- D Garcia de la Serrana
- D Schmidt
- Daniel Baron
- Diego Crespo
- DJ Glass
- E Sarropoulou
- FA Vieira
- FA Vieira
- G Lamirault
- GC Davey
- H Sampath
- H Taegtmeyer
- I Johnston
- I Zinke
- IA Johnston
- J Briggs
- J Pérez-Sánchez
- J Pérez-Sánchez
- J Sales
- JA Calduch-Giner
- JA Calduch-Giner
- JA Calduch-Giner
- Jaume Pérez-Sánchez
- JM Ntambi
- JMO Fernandes
- Josep A. Calduch-Giner
- Josep V. Planas
- K Hua
- K Kurokawa
- KJ Livak
- L Benedito-Palos
- L Benedito-Palos
- LEC Conceição
- LFC Castro
- LJ Holt
- LMP Valente
- M Ashburner
- M Bauer
- M Liesa
- M Lukk
- M Mingarro
- M Teles
- M Yúfera
- MC Sugden
- ML Quillé
- MS Rafael
- MW Hulver
- N Kang-Decker
- N Oksbjerg
- P Feuerstein
- P Gómez-Requeni
- P Prunet
- Patrick Prunet
- PY Rescan
- R Sreekumar
- RCY Lin
- S Ferraresso
- S Lkhagvadorj
- SA Collins
- SH Lecker
- SJ Fuller
- T Jung
- T Kayo
- X Zheng-Bradley
- Y Higami
- Y Hinits
- Y Moreau
- Yann Echasseriau
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis
- Author
- A Korwitz
- A. Saskia Venne
- AE Civitarese
- AM Verhagen
- AS Venne
- AS Venne
- B Head
- BP Eckelman
- C Du
- C Frezza
- C Saunders
- D Ghezzi
- D Mossmann
- DC Chan
- DP Narendra
- DZ Mokry
- E Rettinger
- E Schrepfer
- FA Ran
- G Chen
- G Shi
- GA McQuibban
- GS Salvesen
- H Kashkar
- H Okada
- H Sesaki
- Hamid Kashkar
- Hendrik Nolte
- J Chai
- J Cox
- J Cox
- J Rappsilber
- J D Hunter
- J M Burkhart
- J M Capo-Chichi
- J M Seeger
- J R Chao
- Kai Uwe Fiedler
- L Burri
- L Griparic
- L Pernas
- L Yang
- M Freeman
- M Herlan
- M Holcik
- M Kanabus
- M Liesa
- Marcus Krüger
- N Ishihara
- P Luciano
- PJ Jost
- PM Quiros
- R Anand
- R Mannhold
- René P. Zahedi
- RJ Youle
- S Cipolat
- S Duvezin-Caubet
- S Ehses
- S Heinitz
- S Sekine
- SB Wortmann
- Shotaro Saita
- SM Jin
- T MacVicar
- T Wai
- TE Thingholm
- Thomas Langer
- VA Morais
- VG Tusher
- W Li
- X Jiang
- Y Horibata
- Z Song
- Z Wang
- ZT Schug
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus
- Author
- A Baksi
- A Bergouignan
- A Chinet
- A Garnier
- A Joseph
- A Kalsbeek
- A Ludzki
- A Mottis
- A Navarro
- A Pan
- A Zorzano
- AA Gupte
- AE Civitarese
- AK Madiraju
- AM Diehl
- AR Konopka
- B Brunmair
- B Glancy
- B Karlsson
- B Literati-Nagy
- B Westermann
- BA Irving
- C Canto
- C Canto
- C Lee
- C Lee
- C Meisinger
- C Mielke
- CB Peek
- CE Amara
- CE Fealy
- CR Bruce
- CR Hancock
- CS Choi
- CT Liu
- D Bach
- D Hood
- D Jacobi
- D Sebastian
- D Tondera
- DA Patten
- DC Henstridge
- DE Befroy
- DE James
- DE Kelley
- DE Kelley
- E Phielix
- E Phielix
- E Woldt
- EJ Anderson
- ET Poehlman
- EV Menshikova
- F Song
- F Toledo
- FA Scheer
- FG Toledo
- G Kemp
- G Schatz
- G Twig
- GA Cortopassi
- GI Shulman
- H Carter
- H Ding
- H Shibata
- H Wallberg-Henriksson
- HF Jheng
- HR Waterham
- HS Jung
- I Kurucz
- I Pagel-Langenickel
- IE Wallin
- J Chung
- J Dumas
- J Henson
- J Hoeks
- J Karolkiewicz
- J Lin
- J Rutanen
- J Traba
- J Yoshino
- JA Baur
- JA Levine
- JA Pospisilik
- JC Milne
- JD Wikstrom
- JW van Dijk
- K Gariani
- KF Petersen
- KF Petersen
- KI Stanford
- KL Eckel-Mahan
- KR Short
- KT Howitz
- L Guarente
- L Lindeboom
- L Storlien
- L Yin
- LK Heilbronn
- LM Sparks
- LP Milligan
- M de Ligt
- M den Hoed
- M Herlan
- M Hey-Mogensen
- M Liesa
- M Mensink
- M Nabben
- M Schiff
- Matthijs K. C. Hesselink
- MD Hirschey
- ME Patti
- MI Hernandez-Alvarez
- MJ Betz
- MJ Davies
- MJ Hanssen
- MJ Hanssen
- MK Shigenaga
- MS Hood
- N Turner
- NC Bal
- O Marton
- P Randle
- P Schrauwen
- P Schrauwen
- Patrick Schrauwen
- PJ Randle
- PL Hooper
- PM Coen
- Q Sun
- R Cartoni
- R Ringseis
- R Thomas
- RC Meex
- RC Noland
- RH Unger
- S Bajpeyi
- S Cipolat
- S Kajimura
- S Matsuzaki
- S Pich
- S Satapati
- S Summermatter
- S Timmers
- S Timmers
- S Zuchner
- SE Seiler
- SJ Mihalik
- SK Hutchison
- SK Malin
- SK Maurya
- T Finkel
- T van de Weijer
- T Watanabe
- TR Koves
- V Ljubicic
- V Romanello
- VB Ritov
- VB Schrauwen-Hinderling
- Vera Schrauwen-Hinderling
- VK Mootha
- WD van Marken Lichtenbelt
- Y Suwazono
- YJ Lee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
- Author
- Abalos-Galito M
- Abboy C
- Abrahamian F
- Abreu E
- Ackerman If
- Acosta Ia
- Adams L
- Adaoag Aa
- Adiaz-Baui Tt
- Aggarwal Nk
- Aguilar Dominguez Pe
- Aguilar-Orozco Ra
- Aguirre Sosa I
- Ahmed M
- Aleksandrova E
- Alekseeva E
- Alexandrescu Ds
- Ali Mi
- Allen GG Jr
- Allen Dr
- Allison Dc
- Altieri Hh
- Alvey Jc
- Alwine Lk
- Amer L
- Anand S
- Andrasofszky Z
- Anspach Rb
- Antuni Jd
- Antépara Ercoreca I
- Anwar J
- Apaliski Sj
- Arastu Rs
- Aries Sp
- Arimah C
- Arnedillo Muñoz A
- Arora Cm
- Arthur Cp
- Asherova I
- Auerbach D
- Austri Investigators
- Azzam Sj
- Babyesiza A
- Backer V
- Badar FL 3rd
- Badat A
- Baker Jw
- Balakrishnan K
- Balthazar Y
- Banovcin P
- Barasch Jp
- Barbarash Ol
- Barbe Illa F
- Barber Ma
- Bardin Pg
- Bardinas-Rodriguez R
- Barnes Nc
- Barreiro López B
- Barreiro Tj
- Barros Monge Mj
- Barth D
- Bartha A
- Bartuzi Z
- Bassa A
- Bauler A
- Baumbach Rr
- Baur Ce
- Baxter Bs
- Beach Jl
- Beasley Rl
- Beavins Je
- Beliveau Wj
- Benbow Mj
- Benedix A
- Bennett Nl
- Bennett Rl
- Berenfus Vi
- Berg P
- Bergna Ma
- Bergtholdt B
- Bernal H
- Bernan Ap
- Bernstein Di
- Besh L
- Bettig U
- Bielous-Wilk A
- bin Abdul Aziz Fa
- Bindig Hw
- Blaiss Ms
- Blanco Aparicio M
- Blumenthal Kw
- Boada Valmaseda A
- Boas Sr
- Bolivar Grimaldos F
- Bolliger Ct
- Bonavia M
- Borders Jl
- Boscia Ja
- Bosque García M
- Botzen U
- Boulware Wn
- Bowling Bt
- Bożek A
- Brabec Ba
- Braga M
- Bramlet Dg
- Brautigam Df
- Breedt J
- Brehler R
- Breyer Go
- Brown V
- Brownell Jm
- Bruce Tr
- Bruckhaus-Walter M
- Bruning A
- Brzostek J
- Buaron Ks
- Bugrova O
- Bukreeva Eb
- Buresova M
- Burhan H
- Bursova J
- Bustamante Ruiz A
- Butkovic-Tomljanovic R
- Błażowski Ł
- Call Rs
- Calvo Gil Ma
- Campbell Ca
- Canaan Ya
- Cannon Df
- Carpio Jm
- Carretero Anibarro P
- Carroll Pa
- Castillo Hofer Cr
- Cathcart Ws
- Cerveri I
- Cevallos Jp
- Chapman Kr
- Chaudhuri R
- Chauhan Av
- Cheng Sl
- Chermenskiy A
- Chern Jh
- Chetta Aa
- Chevalier D
- Chiu Mh
- Chizhova O
- Choi I
- Chomiciene A
- Chorostowska-Wynimko J
- Christensen J
- Christensen Ta
- Christina Mo
- Chrzanowski Rr
- Chuang Rb
- Chung Cl
- Ciekalska K
- Cieslicki J
- Cirule I
- Cisneros Am
- Civitarese Fa
- Clark Jp
- Clements Bs
- Clifford Dp
- Coggi Ja
- Cohen Kr
- Collier D
- Collins Bg
- Collins H
- Comellas A
- Condit J
- Cordasco EM Jr
- Corder Cn
- Covar Ra
- Coverston Kd
- Crimi N
- Croce Sa
- Cruz H
- Csanadi Ma
- Cuadrado Ja
- Curtis Ct
- Cutrera R
- Daftary Pk
- Dalan D
- Dalawari Sp
- Daly Wc
- Dapper T
- Daud M
- Davies Ej
- Davis Kc
- Davoliene I
- Dawes Kw
- De Gennaro Ms
- De Rosa M
- De Valle Ol
- Decotiis Ba
- Del Campo Matias F
- Deluca Rf
- Demko I
- Desantis Dm
- Dhillon R
- Diaz Amor Pv
- Diaz Jd
- Diaz Jl
- Dice Jp
- Dimitrova R
- Dimova D
- Diogo Jj
- Dixon C
- Djajalaksana S
- Dobkin La
- Dobrusin Rs
- Dopudja Pantic V
- Dore Nd
- Dransfield Mt
- Dudnyk O
- Duka Kd
- Dupont Lj
- Ebbeling Wl
- Echave-Sustaet Jm
- Eckhard Jg
- Edwards Jd
- Eglite R
- Elacion Jm
- Elizalde A
- Elkayam D
- Ellery A
- Ellis Gc
- Ellison Wt
- Elsen Jr
- Emanuel S
- Emeryk A
- Emmett Ah
- Engel Lr
- Engelhard R
- Ensz Dj
- Ericksen Cl
- Ervin Je
- Espinosa de los Monteros Garde Mj
- Esposito S
- Estrella Viladegut Ra
- Evdokimova A
- Fang C
- Farkas M
- Farrah Vb
- Fazio Lizandrelo Cl
- Feldmeyer F
- Field Jd
- Figueroa Dp
- Fishman Hj
- Fissan H
- Fitzgerald Da
- Florea R
- Focauld F
- Focil A
- Folcik K
- Foresi A
- Forstner B
- Fouche Lf
- Franco MA Jr
- Frandsen Br
- Franz Kh
- Fratrik J
- Frick Bs
- Fulat Ma
- Funck J
- Fushtey Im
- Gammeri E
- Gani M
- Ganti K
- Garcia Hernandez Gm
- Garcia Fl
- Garmash N
- Garscadden Ag
- Garza-Salinas S
- Gatti Ea
- Gattolin G
- Gawlik R
- Gałuszka-Bilińska A
- Gellady Am
- George Ar
- Gessner Cm
- Gibbon Gw
- Giejlo M
- Ginko T
- Giorgadze Ml
- Gleason Gp
- Godlevska O
- Goldberg P
- Goldstein Mf
- Gonzalez Ge
- Gosn Am
- Gower Rg
- Grande Ja
- Gregory D
- Grigat Ce
- Grigoryev S
- Grimm-Sachs V
- Griskeviciene V
- Groth G
- Grubb Sd
- Guthrie Rp
- Guttlerova E
- Gömöri K
- Haas Ta
- Haft Ks
- Hajal R
- Hamelmann E
- Hammond Gd
- Hampf J
- Hanf G
- Hansel Nn
- Hansen Vr
- Harat R
- Harris Af
- Hartman An
- Hartman P
- Harvey Rr
- Havasi-Jost G
- Hazan-Steinberg S
- Headley Dm
- Hegedus-Jungvirth M
- Heigerick Gc
- Heinz Gu
- Heller Bn
- Helm K
- Hendrix El
- Henein S
- Herrod Jn
- Hewitt Mj
- Hines Rl
- Hirdt Ap
- Hirschfield Ja
- Hoeltz S
- Hoffman Ks
- Hofman T
- Hofmann S
- Hogan Ad
- Horvathova H
- Hosler Mr
- Hospodarskyy I
- Howland Wc
- Hsu Cc
- Hsu Fj
- Hubbard Wm
- Hudson Jd
- Huffman C
- Hussain M
- Iashyna L
- Idrisova E
- Iemoli E
- Ioachimescu Oc
- Irkhina I
- Ismail Ai
- Ismail Ms
- Ismail Ym
- Ivkovic-Jurekovic I
- Jaffrani Na
- Jahnz-Różyk K
- Jander R
- Jandl M
- Jasch-Hoppe B
- Jedrzejczak M
- Jiang N
- Jirmanova I
- Johnsen Cr
- Jones Sw
- Jordan Rs
- Joshi Ke
- Jung T
- Junggeburth Jj
- Jurgens Jc
- Kaashmiri Mw
- Kachel T
- Kaik G
- Kaladze M
- Kalafer M
- Kalina P
- Kamdar Ba
- Kamiński D
- Kanuga Jg
- Kao Nl
- Karako P Sr
- Kardos P
- Karetzky M
- Katsetos Jc
- Kay Js
- Kelly Aj
- Kelm Warchol A
- Khurkhurova Nv
- Khvelos Si
- Kim C
- Kim Js
- Kim Wj
- Kimmel Ma
- Kimura Sh
- Kingsley Jk
- Kirstein Jl
- Kis S
- Kissyova Ibrishimova G
- Kleerup Ec
- Klein Rm
- Knueppel W
- Koch T
- Koeberl Gh
- Koh Dw
- Koh Yy
- Kohli N
- Kolman P
- Kolorz C
- Kondyurina Eg
- Konieczny Z
- Korduan M
- Korth-Wiemann B
- Kostin Vi
- Kostromina Vp
- Koura Fa
- Kovacs Sp
- Krakhmalova O
- Kral Km
- Krasko Mp
- Kratzer J
- Kreit Ci
- Kreutter Fm
- Krezdorn Hg
- Kroker A
- Kruell M
- Kryuchko T
- Kubicki Tm
- Kucera M
- Kudelya L
- Kuehne P
- Kulynych Ov
- Kwasniewski A
- Kwok S
- Kwon Ss
- Labuda Jm
- Lai Rs
- Laleko Sl
- Lam As
- Lapidus Rj
- Lara Mm
- Larrateguy Ld
- Latorre Aj
- Lechin Ae
- Lee Jj
- Lee Md
- Lee S
- Lee Sh
- Lee Sk
- Lee Wm
- Legnani Dl
- Lenk U
- Lenney W
- Lenskaya L
- Lentnek Al
- Lenz Jj
- Lesh Kw
- Leszczyński W
- Levashov S
- Levchenko O
- Levins Pf
- Levinsky Dm
- Lezana Soya V
- Liefring E
- Liem Jj
- Lillestol Mj
- Lim H
- Lin Ck
- Litvinova T
- Liu Yc
- Livezey Md
- Lloyd-Turney Cw
- Loboshka Becheva M
- Lockey Rf
- Logvinenko N
- Long Ra
- Lores Obradors L
- Lougheed Md
- Lowe Dw
- Luengo Planas Mt
- Luisetti M
- Lynch Mj
- López Viña A
- Macgillivray Bk
- Machkovska M
- Madjarov S
- Mahadevan Kp
- Mahmood Sm
- Major K
- Makam Sk
- Maloney Mj
- Maltbaek N
- Mandazhieva Pepelanova M
- Mapel D
- Marcipar Am
- Margolis Bd
- Margulies J
- Martin Ee
- Martin Ef
- Martinot Jb
- Martynov A
- Mascolo M
- Maspero Jf
- Mataria H
- Mathur Rn
- Matsuno Fuchigami A
- Mattar Pn
- Maynard Km
- Maynard N
- Mccormick B
- Mcelya M
- Mcevoy Ce
- Mckenzie Wc
- Md Kassim Rm
- Medina Iv
- Medwedeff Le
- Mehta Kd
- Melamed Ir
- Meli Jv
- Merke J
- Merrick Bh
- Meyers Pj
- Mezei M
- Michetti G
- Micke L
- Miller Bt
- Mincewicz G
- Minton Sm
- Miranda Fg
- Mitic Milikic M
- Mitlehner W
- Mizernitski Y
- Mohar De
- Mohd Fadzli Fb
- Monsó Molas E
- Montenegro Ch
- Morris Fa
- Morrison Bs
- Moss Mh
- Mueller H
- Munoz F
- Mészáros I
- Nadaskic R
- Naidenova I
- Naini Gr
- Nakamura Ct
- Naseeruddin S
- Nassim C
- Naudts If
- Naudziunas A
- Naudziunas S
- Navarro Dourdil A
- Navazo Lj
- Nayyar S
- Neamtu Ml
- Nell H
- Nemtsov B
- Nestorovic B
- Neumann G
- Nieto García Aj
- Nieuwoudt G
- Niezgoda K
- Ninane V
- Nissim Je
- Noleva K
- Noor F
- Nordstrom M
- Norman D
- Novozhenov Vg
- O'Connor Tm
- Oberoi Ms
- Offenberger J
- Oldenburg W
- Olszewska-Ziąber A
- Onasz-Manitius M
- Onia Af
- Orr Rr
- Osea Ea
- Overlack A
- Paine Wj
- Palatnik M
- Pandya Hc
- Pangtay D
- Panina Ss
- Panuto Ja
- Panzer F
- Park Cs
- Parker Iw
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:
The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.
METHODS:
In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of life-threatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone-salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation.
RESULTS:
Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone-salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthma-related event in the fluticasone-salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P=0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthma-related intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone-salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone-salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P<0.001).
CONCLUSIONS:
Patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. Patients receiving fluticasone-salmeterol had fewer severe asthma exacerbations than did those in the fluticasone-only group
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- V Andersen
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- VT Tustanovskii
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- W Arnold
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- W Henning
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- W Kreische
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- W Kuhn
- W Kuhn
- W Kutschera
- W Meckback
- W Moller
- W Niessner
- W Parker
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- W Smolec
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- WK Dagenhart
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- WR Gibbs
- WR Gibbs
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- WR Wylie
- WR Wylie
- WV Conner
- WV Hassenzahl
- Wvander Eijk
- WW Bowman
- WW Daehnick
- WZ Wade
- Y Abgrall
- Y Alexander
- Y Alexander
- Y Avishai
- Y Bornec
- Y Chanut
- Y Chanut
- Y Chanut
- Y Civelekoglu
- Y Dar
- Y Dmitrevskii
- Y Eisen
- Y Eisenberg
- Y Futami
- Y Iwasaki
- Y Kagawa
- Y Kanda
- Y Leduigou
- Y Masri
- Y Shamai
- Y Sugiyama
- Y Suzuki
- Y Uemura
- Y Yamazaki
- Y Yang
- YA Berdnikov
- YA Berezhnoj
- YA Shcherbakov
- YA Volchek
- YD Bayukov
- YG Mashkarov
- YG Sevast’yanov
- YH Shen
- YK Gavrilov
- YP Antuf’ev
- YP Dmitrevskii
- YR Gismatullin
- YS Horowitz
- YS Korotkin
- YT Borzunov
- YT Borzunov
- YT Borzunov
- YT Borzunov
- Yu Gorodkov V
- Yu Sevast’yanov
- YW Lui
- YY Chu
- Z Basrak
- Z Fraenkel
- Z Hulek
- Z Majka
- Z Zinamon
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZG Werner
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1981
- Field of study