1 research outputs found
Circulating neutrophil counts and mortality in septic shock
ProducciĂłn CientĂficaPolynuclear neutrophils can play dual roles in sepsis:
on the one hand they mediate major antimicrobial
activities and on the other hand they can contribute
to the development of multiple organ failure [1].
Nonetheless, in spite of the importance of these cells
in sepsis, the influence of the circulating neutrophil
count (CNC) on the prognosis of septic patients with
this pathology has not been properly evaluated.
We analyzed the association between CNC and outcome
in two cohorts of patients with diagnostic criteria
of septic shock (SS) [2]: the first was recruited in the
context of a single center study (EXPRESS study, discovery
cohort, n = 195; Table 1), and the second in the context
of a multi-centric study (GRECIA study, validation
cohort, n = 194; Table 2). Written informed consent was
obtained from each patient or their legal representative.
The two studies were approved by the Research Ethics
Committee of the Hospital ClĂnico Universitario, Valladolid,
Spain (for the EXPRESS study) and Hospital Universitario
RĂo Hortega, Valladolid, Spain (coordinating
center for the GRECIA study).Instituto de Salud Carlos III (grant PI 10/01362)Junta de Castilla y LeĂłn (grant BOCYL-D-26072010