Coexistence of increased arterial stiffness and interatrial block in overweight subjects

PubMed ID: 31707766Background: Interatrial block (IAB) is an electrical conduction delay between the right and left atrium and is associated with some cardiovascular disorders. Arterial stiffness is a useful prognostic marker for cardiovascular events. In the present study, we aimed to investigate the coexistence of increased arterial stiffness and IAB in overweight subjects. Methods: A total of 110 overweight people were enrolled (56 subjects with IAB, and 54 age- and gender-matched subjects without IAB) into the study. Surface 12-lead standard ECGs were recorded. I.E.M. Mobil-O-Graph ambulatory blood pressure monitor device was used to assess the arterial stiffness. Results: The mean age of the patients was 54.1 ± 11.5 years, and 53.6% were male. PWV and Aix were significantly higher in IAB (+) group than IAB (?) group (9.34 ± 1.5 vs. 7.86 ± 1.3, p <.001; 29.18 ± 11.2 vs. 22.75 ± 10.4, p <.001, respectively), and also, positive linear correlation was observed between arterial stiffness parameters and P-wave duration (r =.758 for PWV; r =.682 for Aix, respectively). Conclusion: The present study is the first to focus on evaluating the relationship between the presence of IAB and arterial stiffness in overweight subjects. If there is a coexistence of increased arterial stiffness and IAB in overweight subjects, it should be considered as requiring clinically closer follow-up. © 2019 The Authors. Annals of Noninvasive Electrocardiology published by Wiley Periodicals, Inc

Bisphosphonate Adaptors for Specific Protein Binding on Zirconium Phosphonate-based Microarrays.

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Le dosage par spectroscopie proche infrarouge, Application au test de l'uniformité de teneur des comprimés II

The first part of this article [1] described the methodology to follow to develop a technique for the quantitative analysis of active substance in a solid tablet type formulation using near infrared spectroscopy. It seems appropriate to complete this description by detailing the different steps involved through illustrated examples and by proposing useful guidelines for new users. The quantitative analysis example chosen is that of content uniformity (CU) of tablet type solid forms (cf. Ph. Eur. 2.9.6/2.9.40) [2], a test required in the pharmaceutical industry and for which this alternative quantitative analysis could offer substantial gains. It should be noted that the approach described applies to other types of quantitative analysis (mean assay, water content in raw materials, polymorph assay within a tablet, etc.)

Analyse quantitative par spectroscopie proche infrarouge: Application au test d'unifomité de teneur des comprimés

La spectroscopie Proche infrarouge présente un large potentiel d'applications dans l'industrie pharmaceutique par sa capacité à transmettre des informations reliées à la fois à la structure chimique des échantillons et à leur état physique. Elle peut être mise à profit pour des analyses qualitatives, telles l'identification des matières premières, et également pour des analyses quantitatives telles le dosage d'un principe actif dans un comprimé. Avec pour avantage une rapidité inégalée pour délivrer un résultat comparée aux techniques classiques en vigueur. Attrayante par ses performances, cette spectroscopie nécessite cependant une prise en main qui doit respecter une démarche minutieuse et souvent déroutante par son aspect heuristique (allers-retours) et à la mise en oeuvre d'outils d'analyse statistique multivariée. Si de nombreuses publications témoignent de la puissance de cet outil, il est apparu opportun de rassembler en un même texte la démarche de développement à suivre et les repères à connaître pour permettre son utilisation en analyse quantitative dans un contexte de libération pharmaceutique. Le travail de cette commission a été de rassembler les éléments issus de la pratique industrielle en se concentrant sur l'un des essais les plus intéressants: celui de l'uniformité de teneur des comprimés. Ce test est en effet l'une des applications où la rapidité de mise en oeuvre est le plus appréciable, tout en étant celui qui peut poser le plus de questions quant à la validité des résultats et la prise de décision pharmaceutique

Le dosage par spectroscopie proche infrarouge, Application au test de l'uniformité de teneur des comprimés, I. Méthodologie

This first document describes guidelines to develop a quantification method for active pharmaceutical ingredient content in solid dose formulation, using near-infrared spectroscopy. This new approach offers several advantages over classical techniques, in particular for tablets content uniformity determination. This document is intended to help users addressing the numerous questions pertaining to number and types of samples, usable spectral range for quantification, importance of the reference method, development of a model and potential pitfalls, use of chemometrics tools and method validation. It also offers a statistical support that used as an aid for decision for routine controls, when a sample falls near acceptance limits. The document gathers basic principles and will be complemented by a second article with practical examples to illustrate the methodology

LIPID LOWERING THERAPY USE IN SECONDARY PREVENTION: AN ANALYSIS OF EPHESUS STUDY

87th Congress of the European-Atherosclerosis-Society (EAS) -- MAY 26-29, 2019 -- Maastricht, NETHERLANDSWOS: 000482110800616European Atherosclerosis So