3 research outputs found
67Cu Production Capabilities: A Mini Review
Is the 67Cu production worldwide feasible for expanding preclinical and clinical studies?
How can we face the ingrowing demands of this emerging and promising theranostic radionuclide for
personalized therapies? This review looks at the different production routes, including the acceleratorand reactor-based ones, providing a comprehensive overview of the actual 67Cu supply, with brief
insight into its use in non-clinical and clinical studies. In addition to the most often explored nuclear
reactions, this work focuses on the 67Cu separation and purification techniques, as well as the target
material recovery procedures that are mandatory for the economic sustainability of the production
cycle. The quality aspects, such as radiochemical, chemical, and radionuclidic purity, with particular
attention to the coproduction of the counterpart 64Cu, are also taken into account, with detailed
comparisons among the different production routes. Future possibilities related to new infrastructures
are included in this work, as well as new developments on the radiopharmaceuticals aspect