Alpha-1-antitrypsin deficiency and bronchiectasis: A concomitance or a real association?

Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes’ predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are a cough, sputum production and frequent respiratory exacerbations. In the literature, there are many papers concerning these two clinical entities, but there is still a lot of debate about a possible association between them, in particular about the frequency of their association and causal links. The aim of this short communication is to show the literature reports about the association between AATd and bronchiectasis to establish the state of the art and possible future developments in this research field

Assessing the Social Entrepreneurship Business Model. An Exploratory Case Study in the Italian Cultural Heritage Sector

Social entrepreneurship (SE) has gained prominence in recent years, becoming a primary field of study and providing rich research opportunities that are both challenging and intriguing. This paper seeks to fill the knowledge gap in this field by improving the understanding of business models of SE and, more specifically, investigating how social entrepreneurs design their business models in order to create both social and economic value. Using the abductive approach method, the paper explores a single case study that enquires about the business model of the social enterprise named "La Paranza Cooperative", located in southern Italy and operating in the cultural heritage industry. Our main theoretical contribution lies in illustrating and formalising the ambidexterity perspective through which social enterprises simultaneously pursue goals that are apparently contradictory, such as economic and social ones. Furthermore, on the practical side, we assess the win-win managerial mechanisms that benefit social enterprises through their external environment as a bundle of distinctive resources while contributing to its requalification. Finally, our explorative study opens-up for deeper and more detailed future research on the business model of SE

Assessing the Social Entrepreneurship Business Model: An Exploratory Case Study in the Italian Cultural Heritage Sector

Social entrepreneurship (SE) has gained prominence in recent years, becoming a primary field of study and providing rich research opportunities that are both challenging and intriguing. This paper seeks to fill the knowledge gap in this field by improving the understanding of business models of SE and, more specifically, investigating how social entrepreneurs design their business models in order to create both social and economic value. Using the abductive approach method, the paper explores a single case study that enquires about the business model of the social enterprise named “La Paranza Cooperative”, located in southern Italy and operating in the cultural heritage industry. Our main theoretical contribution lies in illustrating and formalising the ambidexterity perspective through which social enterprises simultaneously pursue goals that are apparently contradictory, such as economic and social ones. Furthermore, on the practical side, we assess the win–win managerial mechanisms that benefit social enterprises through their external environment as a bundle of distinctive resources while contributing to its requalification. Finally, our explorative study opens-up for deeper and more detailed future research on the business model of SE

Didactic "Harmonies" in a Bioeducational Perspective

While singling out the dialogue between biology and culture as a privileged site where musical language can be read as “complex phenomenon”, this essay moves from a bioeducational perspective in order to analyze learning as a fundamentally adaptive process i.e. the result of a synergic pathway, permeated by inter-active dynamics that involve subjects in their inseparableness of mind, body and organism. he relationship body, sounds and action promotes original didactic musicalities, which, hinging on a bioeducational perspective of the teaching-learning process, represent a simplexity, as an accessible variation of the didactic action

Severe depletion of peripheral blood dendritic cell subsets in obstructive sleep apnea patients: A new link with cancer?

Recent evidence suggests that alterations of the immune responses are associated with the inflammatory nature of obstructive sleep apnea (OSA) and of its related co-morbidities. In this scenario, we asked whether circulating dendritic cell (DC) subsets may be possible players as their role has not yet been detailed. The frequency distribution of peripheral blood myeloid (mDC1 and mDC2) and plasmacytoid (p) DCs was investigated by mean of multi-parametric flow cytometry in 45 OSA patients (mean age: 53 yrs; M = 29) at the time of the first diagnosis and compared to 30 age- and sex-matched healthy controls. Oxidative burst (OB) and serum levels of tumor necrosis factor (TNF)-α, (interleukin) (IL)-6, interferon (INF)-γ, IL-2, IL-4, IL-10 and vascular endothelial growth factor (VEGF) were also analyzed. All subsets of circulating DCs were significantly depleted in OSA patients as compared to healthy subjects (p 30) and were inversely correlated with both mDC2 (r = −0.802, p < 0.007) and pDC (r = −0.317, p = 0.04) subsets. We first provide evidence for a constitutive reduction of all circulating DC subsets in OSA patients. Perturbation of DCs coexists with an inflammatory milieu and is negatively correlated with the expression of IL-6, which is actually recognized as a pivotal inhibitor of DC maturation. Future studies exploring the contribution of DCs in the pathogenesis of OSA and of its complications should be encouraged

Endemic goiter and iodine deficiency diffusion in province of Avellino

1352 schoolchildren between 6-14 years old (699 males and 653 females) and 943 adults (176 males and 767 females) from eight villages of the province of Avellino were studied. All subjects were examined for thyroid size by at least two expert examiners. In most of them urine samples were collected for iodine determinations. 387 schoolchildren and 161 adults from Flumeri and Villanova were evaluated by thyroid echography. The prevalence of goiter was from 23.5 to 52.2% and the median urinary iodine excretion was from 42.3 to 66.2 μg/l in schoolchildren. In adults the prevalence of goiter was from 41.2 to 86.7% and the median urinary iodine excretion was from 37.1 to 53.7 μg/l. Our data showed a degree of iodine deficiency from low to moderate. The echography permitted to point out a greater prevalence of nodules than the thyroid palpation