6 research outputs found
In vivo effect of pneumonia on surfactant disaturated-phosphatidylcholine kinetics in newborn infants
Bacterial pneumonia in newborns often leads to surfactant deficiency or dysfunction, as surfactant is inactivated or its production/turnover impaired. No data are available in vivo in humans on the mechanism of surfactant depletion in neonatal pneumonia. We studied the kinetics of surfactant's major component, disaturated-phosphatidylcholine (DSPC), in neonatal pneumonia, and we compared our findings with those obtained from control newborn lungs
Clinical characteristics of study patients.
<p>Clinical characteristics of study patients.</p
DSPC half-life (HL) and pool size (PS) in the two study groups.
<p>Panel A: Median DSPC HL in the two groups. DSPC HL was significantly shorter in newborns with pneumonia (light grey box) compared with newborns with no lung disease (grey box). Data are expressed as median (IQR). Panel B: Median DSPC PS in the two groups. DSPC PS was significantly lower in newborns with pneumonia (light grey box) compared with newborns with no lung disease (grey box). Data are expressed as median (IQR).</p