Additional file 1: Table S1. of 5Îą-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis

PRISMA 2009 Checklist. (DOC 70 kb

Additional file 2: of 5Îą-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis

The search strategy and excluded studies with reasons. (DOCX 28 kb

Additional file 3: Table S2. of 5Îą-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis

Data from the studies included in the meta-analysis. (DOCX 17 kb

Changes of metabolic and endocrine variables in obese PCOS model induced by high-fat diet.

<p>Values are means ± SD.</p><p>*p<0.0167 versus CO by Bonferoni post-hoc test.</p>#<p>p<0.0167 versus PO by Bonferoni post-hoc test.</p

Changes of ovarian morphological parameters in PF.

<p>Values are means ± SD.</p><p>*p<0.0167 versus CO by Bonferoni post-hoc test.</p

Figures and cell types of vaginal smears.

<p><b>A</b>: preoestrus, loaded mainly with epithelial cell; <b>B</b>: estrus, loaded mainly with keratinocytes; <b>C</b>:metoestrus,displaying epithelial cell, keratinocytes, and leukocytes; <b>D</b>:diestrus, displaying full of leukocytes (magnification ×100).</p

Effects of exercise and diet on metabolic and endocrine variables in PF rats.

<p>Values are means ± SD.</p><p>*p<0.0167 versus PF-SF by Bonferoni post-hoc test.</p>#<p>p<0.0167 versus PF-EF by Bonferoni post-hoc test.</p

Additional file 1 of Exploration of programmed cell death-associated characteristics and immune infiltration in neonatal sepsis: new insights from bioinformatics analysis and machine learning

Supplementary Material 1: Table S1. Baseline characteristics of the patients of GSE25504 (GPL6947 platform

Table1_Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia.XLSX

Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associated with BPD. Twenty-five BPD-related DE-PRGs were identified, all of which were closely associated with pyroptosis regulation and immunological response. LASSO and SVM-RFE algorithms identified CHMP7, NLRC4, NLRP2, NLRP6, and NLRP9 among the 25 differentially expressed PRGs as marker genes with acceptable diagnostic capabilities. Using these five genes, we also generated a nomogram with excellent predictive power. Annotation enrichment analyses revealed that these five genes may be implicated in BPD and numerous BPD-related pathways. In addition, the ceRNA network showed an intricate regulatory link based on the marker genes. In addition, CIBERSORT-based studies revealed that alterations in the immunological microenvironment of BPD patients may be associated with the marker genes. We constructed a diagnostic nomogram and gave insight into the mechanism of BPD. Its diagnostic value for BPD must be evaluated in further research before it can be used in clinical practice.</p

Table2_Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia.XLSX

Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associated with BPD. Twenty-five BPD-related DE-PRGs were identified, all of which were closely associated with pyroptosis regulation and immunological response. LASSO and SVM-RFE algorithms identified CHMP7, NLRC4, NLRP2, NLRP6, and NLRP9 among the 25 differentially expressed PRGs as marker genes with acceptable diagnostic capabilities. Using these five genes, we also generated a nomogram with excellent predictive power. Annotation enrichment analyses revealed that these five genes may be implicated in BPD and numerous BPD-related pathways. In addition, the ceRNA network showed an intricate regulatory link based on the marker genes. In addition, CIBERSORT-based studies revealed that alterations in the immunological microenvironment of BPD patients may be associated with the marker genes. We constructed a diagnostic nomogram and gave insight into the mechanism of BPD. Its diagnostic value for BPD must be evaluated in further research before it can be used in clinical practice.</p